Motif ID: Nfil3_Tef

Z-value: 2.157

Transcription factors associated with Nfil3_Tef:

Gene SymbolEntrez IDGene Name
Nfil3 ENSMUSG00000056749.7 Nfil3
Tef ENSMUSG00000022389.8 Tef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tefmm10_v2_chr15_+_81811414_818114910.864.4e-18Click!
Nfil3mm10_v2_chr13_-_52981027_529810830.462.9e-04Click!


Activity profile for motif Nfil3_Tef.

activity profile for motif Nfil3_Tef


Sorted Z-values histogram for motif Nfil3_Tef

Sorted Z-values for motif Nfil3_Tef



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfil3_Tef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_55681257 47.700 ENSMUST00000044767.8
 Neurod6
neurogenic differentiation 6
chr1_-_91459254 31.062 ENSMUST00000069620.8
 Per2
period circadian clock 2
chr14_+_65971049 29.163 ENSMUST00000128539.1
 Clu
clusterin
chr14_+_65970804 27.802 ENSMUST00000138191.1
 Clu
clusterin
chr14_+_65971164 24.730 ENSMUST00000144619.1
 Clu
clusterin
chr14_+_65970610 23.239 ENSMUST00000127387.1
 Clu
clusterin
chr6_-_113934679 20.765 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr9_-_40346290 20.607 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr2_-_25469742 19.057 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr5_+_117841839 18.991 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr2_+_131909928 18.735 ENSMUST00000091288.6
 Prnp
prion protein
chr16_+_45093611 16.936 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr11_-_101785252 15.551 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr4_+_85205417 15.529 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr2_-_25470031 15.252 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_+_131909951 15.102 ENSMUST00000124100.1
ENSMUST00000136783.1
 PRND

prion protein gene complex (Prn), transcript variant 1, mRNA

chr14_-_18239053 14.851 ENSMUST00000090543.5
 Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr12_+_74288735 13.647 ENSMUST00000095617.1
 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr1_+_179803376 13.003 ENSMUST00000097454.2
 Gm10518
predicted gene 10518
chrX_-_51681703 12.766 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
17.5 104.9 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
2.4 47.7 GO:0021542 dentate gyrus development(GO:0021542)
0.3 37.6 GO:0007623 circadian rhythm(GO:0007623)
6.9 34.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
3.9 27.2 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.7 24.7 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
4.0 23.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 23.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
5.8 23.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
3.5 20.8 GO:0048840 otolith development(GO:0048840)
4.7 19.0 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
9.4 18.7 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.8 14.9 GO:2001014 regulation of energy homeostasis(GO:2000505) regulation of skeletal muscle cell differentiation(GO:2001014)
0.4 14.4 GO:0008333 endosome to lysosome transport(GO:0008333)
2.4 14.3 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 11.8 GO:0006342 chromatin silencing(GO:0006342)
2.3 11.6 GO:1900170 prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
1.3 11.6 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
2.3 11.5 GO:0051012 microtubule sliding(GO:0051012)
1.0 10.8 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
15.0 104.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.4 31.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 25.9 GO:0031225 anchored component of membrane(GO:0031225)
1.5 23.3 GO:0005614 interstitial matrix(GO:0005614)
1.4 23.1 GO:0043205 fibril(GO:0043205)
1.3 20.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.5 20.8 GO:0032809 neuronal cell body membrane(GO:0032809)
1.7 19.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 16.8 GO:0000790 nuclear chromatin(GO:0000790)
0.1 16.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.6 11.2 GO:0070695 FHF complex(GO:0070695)
0.0 11.2 GO:0045202 synapse(GO:0045202)
1.2 10.4 GO:0005883 neurofilament(GO:0005883)
0.1 10.0 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1 10.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.5 9.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 8.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 8.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.3 7.4 GO:0000786 nucleosome(GO:0000786)
1.4 7.2 GO:0030314 junctional membrane complex(GO:0030314)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 104.9 GO:0051787 misfolded protein binding(GO:0051787)
8.6 34.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 34.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
5.8 29.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 26.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.8 26.4 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
1.6 20.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
6.1 18.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 17.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.7 16.9 GO:0001968 fibronectin binding(GO:0001968)
1.0 16.3 GO:0043008 ATP-dependent protein binding(GO:0043008)
2.5 14.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 14.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 12.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 12.4 GO:0008289 lipid binding(GO:0008289)
1.7 11.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 11.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 10.4 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
2.4 9.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.5 9.7 GO:0004385 guanylate kinase activity(GO:0004385)