Motif ID: Nkx2-1

Z-value: 0.719


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.661.4e-08Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 105 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_103314944 8.501 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr5_+_128601106 7.353 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr8_-_46294592 7.292 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr13_-_71963713 5.879 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr1_+_12718496 5.180 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr2_-_170406501 5.056 ENSMUST00000154650.1
 Bcas1
breast carcinoma amplified sequence 1
chr19_+_44493472 4.588 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr1_+_75450699 4.563 ENSMUST00000037708.9
 Asic4
acid-sensing (proton-gated) ion channel family member 4
chr1_+_75450436 4.405 ENSMUST00000113577.1
 Asic4
acid-sensing (proton-gated) ion channel family member 4
chr4_+_89688196 4.117 ENSMUST00000052478.2
 Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr17_+_34263209 3.801 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr11_+_117849223 3.588 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr3_+_52268337 3.569 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chrX_+_100730178 3.546 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr11_+_117849286 3.224 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chrX_+_58030999 3.202 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr4_-_9643638 3.193 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
 Asph




aspartate-beta-hydroxylase




chr14_-_47411666 3.133 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chrX_-_142390334 2.904 ENSMUST00000112907.1
 Acsl4
acyl-CoA synthetase long-chain family member 4
chr17_+_47737030 2.901 ENSMUST00000086932.3
 Tfeb
transcription factor EB

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.7 GO:0006814 sodium ion transport(GO:0006814)
0.9 7.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.4 7.3 GO:0097154 GABAergic neuron differentiation(GO:0097154)
1.0 6.8 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.0 5.9 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.3 5.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 4.6 GO:0016055 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
0.4 4.1 GO:0060179 male mating behavior(GO:0060179)
0.2 4.1 GO:0032288 myelin assembly(GO:0032288)
0.2 4.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
1.0 3.8 GO:0002339 B cell selection(GO:0002339)
0.4 3.6 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 3.6 GO:0006959 humoral immune response(GO:0006959)
0.4 3.5 GO:0090527 actin filament reorganization(GO:0090527)
1.1 3.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 3.0 GO:0007050 cell cycle arrest(GO:0007050)
0.3 2.9 GO:0032306 regulation of prostaglandin secretion(GO:0032306) embryonic process involved in female pregnancy(GO:0060136)
0.1 2.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.9 2.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.9 2.7 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 8.1 GO:0009986 cell surface(GO:0009986)
0.0 7.9 GO:0005667 transcription factor complex(GO:0005667)
2.3 6.8 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 4.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.5 3.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 3.5 GO:0005884 actin filament(GO:0005884)
0.6 3.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 3.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 2.9 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 2.6 GO:0005901 caveola(GO:0005901)
0.3 2.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.2 2.0 GO:0030056 hemidesmosome(GO:0030056)
0.1 2.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 1.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 1.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 1.5 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.1 GO:0097539 ciliary transition fiber(GO:0097539)
0.2 1.0 GO:0002177 manchette(GO:0002177)
0.1 1.0 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.3 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.3 9.0 GO:0005272 sodium channel activity(GO:0005272)
0.4 8.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 8.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 6.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.0 5.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 4.6 GO:0005109 frizzled binding(GO:0005109)
0.1 4.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 3.8 GO:0015643 toxic substance binding(GO:0015643)
0.2 3.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.4 3.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 3.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 3.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.3 2.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 2.8 GO:0008276 protein methyltransferase activity(GO:0008276)
0.9 2.7 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 2.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.6 GO:0008565 protein transporter activity(GO:0008565)
0.3 2.2 GO:0048495 Roundabout binding(GO:0048495)
0.3 2.1 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)