Motif ID: Nkx2-2
Z-value: 1.263
Transcription factors associated with Nkx2-2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-2 | ENSMUSG00000027434.10 | Nkx2-2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-2 | mm10_v2_chr2_-_147186389_147186413 | -0.04 | 7.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 1.1 | 3.3 | GO:0051542 | elastin biosynthetic process(GO:0051542) |
| 0.9 | 3.7 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.6 | 1.9 | GO:0046078 | deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078) |
| 0.6 | 1.7 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.5 | 2.2 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.5 | 1.6 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.5 | 1.5 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.5 | 1.9 | GO:0034454 | microtubule anchoring at centrosome(GO:0034454) |
| 0.5 | 1.9 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.5 | 1.9 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.5 | 7.5 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.4 | 1.7 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.4 | 1.9 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.4 | 1.9 | GO:0030242 | pexophagy(GO:0030242) |
| 0.3 | 1.4 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.3 | 2.4 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.3 | 3.3 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
| 0.3 | 1.0 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.3 | 3.2 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.3 | 0.9 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine nucleoside monophosphate metabolic process(GO:0009129) pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.3 | 0.9 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.3 | 1.7 | GO:0035087 | siRNA loading onto RISC involved in RNA interference(GO:0035087) |
| 0.3 | 1.1 | GO:1903463 | mitotic cell cycle phase(GO:0098763) regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.3 | 3.2 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.3 | 2.4 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.3 | 0.8 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.2 | 6.3 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.2 | 1.2 | GO:0051461 | regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.2 | 1.7 | GO:1904668 | positive regulation of ubiquitin protein ligase activity(GO:1904668) |
| 0.2 | 0.6 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
| 0.2 | 1.2 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.2 | 5.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 0.9 | GO:2000574 | regulation of microtubule motor activity(GO:2000574) |
| 0.2 | 0.7 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.2 | 1.2 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.2 | 1.9 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.1 | 2.5 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.1 | 0.8 | GO:0006046 | N-acetylglucosamine catabolic process(GO:0006046) |
| 0.1 | 1.2 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
| 0.1 | 0.5 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.1 | 0.3 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.1 | 0.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.1 | 0.4 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 0.1 | 3.6 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.1 | 0.5 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
| 0.1 | 0.3 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
| 0.1 | 0.2 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
| 0.1 | 1.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.6 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.1 | 0.1 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.1 | 0.7 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 0.3 | GO:0070535 | histone H2A K63-linked ubiquitination(GO:0070535) |
| 0.1 | 0.2 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 1.3 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.1 | 0.5 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.1 | 0.4 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 1.2 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.1 | 0.3 | GO:0034214 | protein hexamerization(GO:0034214) |
| 0.0 | 0.9 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 0.1 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.0 | 1.0 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.0 | 0.2 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 0.1 | GO:2000983 | regulation of ATP citrate synthase activity(GO:2000983) negative regulation of ATP citrate synthase activity(GO:2000984) |
| 0.0 | 0.6 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.2 | GO:0009052 | pentose-phosphate shunt, non-oxidative branch(GO:0009052) |
| 0.0 | 0.4 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 0.6 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) |
| 0.0 | 0.1 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.0 | 0.5 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.0 | 0.1 | GO:0036166 | phenotypic switching(GO:0036166) |
| 0.0 | 0.1 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.0 | 1.4 | GO:0017156 | calcium ion regulated exocytosis(GO:0017156) |
| 0.0 | 1.4 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.7 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.4 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.4 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.0 | 0.1 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
| 0.0 | 0.1 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.0 | 1.0 | GO:0007127 | meiosis I(GO:0007127) |
| 0.0 | 0.3 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 0.3 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 1.4 | GO:0051297 | centrosome organization(GO:0051297) |
| 0.0 | 0.4 | GO:0031440 | regulation of mRNA 3'-end processing(GO:0031440) |
| 0.0 | 4.3 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.0 | 0.7 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 0.2 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.2 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.7 | 2.6 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.6 | 1.8 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.5 | 1.4 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.4 | 1.9 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.3 | 2.2 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.3 | 1.2 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.2 | 1.7 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.2 | 4.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 1.3 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 1.7 | GO:0070938 | contractile ring(GO:0070938) |
| 0.1 | 1.9 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 7.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 0.7 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.1 | 1.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 1.2 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 2.7 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 0.5 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 0.5 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500) |
| 0.0 | 0.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.7 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.0 | 0.4 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.5 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597) |
| 0.0 | 1.1 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.0 | 2.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.0 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 2.4 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 3.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.1 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 1.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.9 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 0.2 | GO:0071203 | WASH complex(GO:0071203) |
| 0.0 | 12.2 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 1.1 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 4.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 2.2 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 0.3 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 1.4 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 2.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.5 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0004008 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 0.6 | 1.7 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.4 | 2.1 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.4 | 7.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.3 | 1.4 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.3 | 1.9 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 0.2 | 1.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.2 | 0.7 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 0.2 | 1.8 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.2 | 1.7 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.2 | 0.8 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.1 | 1.0 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.1 | 5.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 1.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 1.9 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.1 | 6.3 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.1 | 1.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 3.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.6 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.1 | 1.6 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 0.6 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 0.5 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 1.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 1.0 | GO:0070636 | single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694) |
| 0.1 | 0.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.2 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.0 | 1.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 1.9 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.5 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.4 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.0 | 0.2 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.0 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 1.7 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.9 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.0 | 4.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.8 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.2 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 1.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.9 | GO:0045502 | dynein binding(GO:0045502) |
| 0.0 | 0.5 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.5 | GO:0015036 | disulfide oxidoreductase activity(GO:0015036) |
| 0.0 | 2.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.2 | GO:0034951 | pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011) |
| 0.0 | 2.0 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 0.4 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 1.3 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.5 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 1.2 | GO:0101005 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 1.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 2.9 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.2 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 0.3 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 0.3 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.2 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.2 | GO:0008327 | methyl-CpG binding(GO:0008327) |
