Motif ID: Nkx2-2

Z-value: 1.263


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_147186413-0.047.7e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3018753 9.805 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr14_-_19418930 9.556 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3034599 8.896 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3025417 8.157 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3005125 7.995 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3015654 7.921 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 7.590 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr10_+_88091070 7.252 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chrX_+_9885622 5.446 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr3_+_5218516 3.998 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr2_-_140170528 3.818 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr9_+_72438519 3.741 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438534 3.712 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr19_-_5796924 3.695 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr3_+_118433797 3.194 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr6_+_5390387 3.177 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr15_-_10470490 2.574 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr11_+_78301529 2.521 ENSMUST00000045026.3
 Spag5
sperm associated antigen 5
chr4_+_59626189 2.488 ENSMUST00000070150.4
ENSMUST00000052420.6
 E130308A19Rik

RIKEN cDNA E130308A19 gene

chr1_-_166002613 2.416 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.5 GO:0070986 left/right axis specification(GO:0070986)
2.4 7.3 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 6.3 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 5.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 4.3 GO:0008380 RNA splicing(GO:0008380)
0.9 3.7 GO:0035063 nuclear speck organization(GO:0035063)
0.1 3.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
1.1 3.3 GO:0051542 elastin biosynthetic process(GO:0051542)
0.3 3.3 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.3 3.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.3 3.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 2.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 2.4 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.3 2.4 GO:0030035 microspike assembly(GO:0030035)
0.5 2.2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.6 1.9 GO:0046078 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
0.5 1.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.5 1.9 GO:0035617 stress granule disassembly(GO:0035617)
0.5 1.9 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.4 1.9 GO:0060242 contact inhibition(GO:0060242)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.2 GO:0005730 nucleolus(GO:0005730)
0.1 7.5 GO:0005882 intermediate filament(GO:0005882)
0.0 4.9 GO:0005667 transcription factor complex(GO:0005667)
0.2 4.5 GO:0034451 centriolar satellite(GO:0034451)
0.8 3.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 3.1 GO:0016607 nuclear speck(GO:0016607)
0.0 3.1 GO:0070382 exocytic vesicle(GO:0070382)
0.1 2.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 2.7 GO:0005902 microvillus(GO:0005902)
0.7 2.6 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 2.4 GO:0030175 filopodium(GO:0030175)
0.3 2.2 GO:0001940 male pronucleus(GO:0001940)
0.0 2.2 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 1.9 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.9 GO:0035253 ciliary rootlet(GO:0035253)
0.6 1.8 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.2 1.7 GO:0070578 RISC-loading complex(GO:0070578)
0.1 1.7 GO:0070938 contractile ring(GO:0070938)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 6.3 GO:0000049 tRNA binding(GO:0000049)
0.1 5.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 4.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
1.1 3.3 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 2.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 2.1 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 2.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.3 1.9 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 1.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.9 GO:0005542 folic acid binding(GO:0005542)
0.1 1.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.2 1.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 1.8 GO:0019894 kinesin binding(GO:0019894)
0.6 1.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 1.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.7 GO:0017166 vinculin binding(GO:0017166)