Motif ID: Nkx2-4

Z-value: 0.521


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_147085483-0.094.8e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Showing 1 to 20 of 75 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_89027959 3.722 ENSMUST00000130041.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr5_+_89028035 2.885 ENSMUST00000113216.2
ENSMUST00000134303.1
 Slc4a4

solute carrier family 4 (anion exchanger), member 4

chr9_-_58159201 2.863 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr3_+_76593550 2.738 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr2_-_147186389 2.587 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr9_-_58158498 2.436 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr13_-_105271039 2.326 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr10_+_4611971 2.312 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr13_-_66852017 2.118 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr11_+_110968016 1.908 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr12_+_38781093 1.858 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr3_+_52268337 1.771 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr1_+_178798438 1.711 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr12_+_38780817 1.677 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr17_+_86753900 1.643 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr17_+_70522083 1.449 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr11_+_110968056 1.368 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_-_115824699 1.345 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr7_-_44670820 1.041 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr5_-_77408034 1.016 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 3.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 3.3 GO:0010107 potassium ion import(GO:0010107)
0.9 2.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.6 2.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 2.3 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.2 2.3 GO:0070842 aggresome assembly(GO:0070842)
0.2 1.8 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.6 1.7 GO:0072092 ureteric bud invasion(GO:0072092)
0.4 1.6 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.1 1.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 1.0 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 1.0 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.0 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
0.1 0.8 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.8 GO:0009395 phospholipid catabolic process(GO:0009395)
0.2 0.7 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.6 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.6 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)
0.0 1.6 GO:0016607 nuclear speck(GO:0016607)
0.2 1.0 GO:0097513 myosin II filament(GO:0097513)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0032009 early phagosome(GO:0032009)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 0.5 GO:0044299 C-fiber(GO:0044299)
0.0 0.5 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 6.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 3.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 3.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 2.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.8 2.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 2.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.6 GO:0050897 cobalt ion binding(GO:0050897)
0.1 1.0 GO:0005243 gap junction channel activity(GO:0005243)
0.1 1.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)