Motif ID: Nkx2-4

Z-value: 0.521


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_147085483-0.094.8e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_89027959 3.722 ENSMUST00000130041.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr5_+_89028035 2.885 ENSMUST00000113216.2
ENSMUST00000134303.1
 Slc4a4

solute carrier family 4 (anion exchanger), member 4

chr9_-_58159201 2.863 ENSMUST00000041477.7
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr3_+_76593550 2.738 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr2_-_147186389 2.587 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr9_-_58158498 2.436 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr13_-_105271039 2.326 ENSMUST00000069686.6
 Rnf180
ring finger protein 180
chr10_+_4611971 2.312 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr13_-_66852017 2.118 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr11_+_110968016 1.908 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr12_+_38781093 1.858 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr3_+_52268337 1.771 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr1_+_178798438 1.711 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr12_+_38780817 1.677 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr17_+_86753900 1.643 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr17_+_70522083 1.449 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr11_+_110968056 1.368 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_-_115824699 1.345 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr7_-_44670820 1.041 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr5_-_77408034 1.016 ENSMUST00000163898.1
ENSMUST00000046746.6
 Igfbp7

insulin-like growth factor binding protein 7

chrX_+_101383726 0.971 ENSMUST00000119190.1
 Gjb1
gap junction protein, beta 1
chr8_+_4248188 0.911 ENSMUST00000110993.1
 Gm14378
predicted gene 14378
chr13_+_65512678 0.898 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr17_+_70522149 0.878 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr19_-_5457397 0.877 ENSMUST00000179549.1
 Ccdc85b
coiled-coil domain containing 85B
chr13_+_108316395 0.856 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr9_-_52679429 0.792 ENSMUST00000098768.2
 AI593442
expressed sequence AI593442
chr4_-_136892867 0.766 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr19_-_6969746 0.762 ENSMUST00000025912.8
 Plcb3
phospholipase C, beta 3
chr2_+_169633517 0.756 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr6_-_97060407 0.754 ENSMUST00000089295.4
 Fam19a4
family with sequence similarity 19, member A4
chr10_+_42502197 0.703 ENSMUST00000105499.1
 Snx3
sorting nexin 3
chr11_-_102579461 0.694 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr10_+_20347788 0.649 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr14_-_47418407 0.629 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr6_+_29398920 0.611 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr2_+_25180737 0.611 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr6_+_134929118 0.577 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr3_+_121291725 0.554 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr8_+_66860215 0.512 ENSMUST00000118009.1
 Naf1
nuclear assembly factor 1 homolog (S. cerevisiae)
chr6_+_134929089 0.510 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr6_+_30568367 0.510 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr15_+_99055164 0.484 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr2_-_63184253 0.478 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr12_-_91746020 0.460 ENSMUST00000166967.1
 Ston2
stonin 2
chr2_+_169632996 0.449 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr7_-_100932140 0.413 ENSMUST00000107032.1
 Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr2_+_156840966 0.407 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr3_+_96696379 0.386 ENSMUST00000107076.3
 Pias3
protein inhibitor of activated STAT 3
chr15_-_26895049 0.355 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr6_+_94500313 0.347 ENSMUST00000061118.8
 Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr10_+_88091070 0.332 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr3_-_59220150 0.321 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr1_+_16105774 0.313 ENSMUST00000027053.7
 Rdh10
retinol dehydrogenase 10 (all-trans)
chr8_-_31739763 0.285 ENSMUST00000178878.1
 Gm5117
predicted gene 5117
chr10_+_128232065 0.244 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chr11_+_98863610 0.224 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr2_-_93046053 0.191 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr5_-_23616528 0.187 ENSMUST00000088392.4
 Srpk2
serine/arginine-rich protein specific kinase 2
chr17_-_51832666 0.187 ENSMUST00000144331.1
 Satb1
special AT-rich sequence binding protein 1
chr18_-_3281036 0.175 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
 Crem


cAMP responsive element modulator


chr12_-_105685235 0.175 ENSMUST00000041055.7
 Atg2b
autophagy related 2B
chr17_+_16972910 0.171 ENSMUST00000071374.5
 BC002059
cDNA sequence BC002059
chr18_-_3281712 0.167 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
 Crem



cAMP responsive element modulator



chr8_-_40308331 0.153 ENSMUST00000118639.1
 Fgf20
fibroblast growth factor 20
chr9_-_71896047 0.132 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr11_+_49247462 0.121 ENSMUST00000109194.1
 Mgat1
mannoside acetylglucosaminyltransferase 1
chr8_+_11556061 0.119 ENSMUST00000054399.4
 Ing1
inhibitor of growth family, member 1
chrX_-_143933204 0.117 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr7_-_80905060 0.099 ENSMUST00000119428.1
ENSMUST00000026817.4
 Nmb

neuromedin B

chr2_+_157456917 0.071 ENSMUST00000109529.1
 Src
Rous sarcoma oncogene
chr3_+_88629499 0.059 ENSMUST00000175745.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr1_-_63114516 0.038 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chrX_-_143933089 0.034 ENSMUST00000087313.3
 Dcx
doublecortin
chr8_+_45627946 0.023 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.6 2.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.6 1.7 GO:0072092 ureteric bud invasion(GO:0072092)
0.4 1.6 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.3 6.6 GO:0015701 bicarbonate transport(GO:0015701)
0.2 0.7 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 1.8 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.2 2.3 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.2 2.3 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 3.3 GO:0010107 potassium ion import(GO:0010107)
0.1 0.3 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.3 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 3.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.8 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.1 1.0 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:0060431 primary lung bud formation(GO:0060431)
0.1 0.6 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 1.0 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.5 GO:1904872 regulation of telomerase RNA localization to Cajal body(GO:1904872) positive regulation of telomerase RNA localization to Cajal body(GO:1904874)
0.0 0.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.8 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.4 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.6 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.5 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.5 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.2 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 1.0 GO:0050810 regulation of steroid biosynthetic process(GO:0050810)
0.0 0.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.4 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.2 GO:0051127 positive regulation of actin nucleation(GO:0051127)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0097513 myosin II filament(GO:0097513)
0.2 0.5 GO:0044299 C-fiber(GO:0044299)
0.1 2.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.7 GO:0032009 early phagosome(GO:0032009)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.0 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)
0.0 0.5 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 6.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 1.6 GO:0016607 nuclear speck(GO:0016607)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.8 2.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 3.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.6 GO:0050897 cobalt ion binding(GO:0050897)
0.1 1.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.0 GO:0005243 gap junction channel activity(GO:0005243)
0.1 1.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 2.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 2.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 1.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 3.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)