Motif ID: Nkx2-5

Z-value: 0.830


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 93 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_31949571 12.992 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr15_-_88978958 12.491 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr1_+_172341197 6.893 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr8_-_46294592 6.769 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr15_-_54919961 5.567 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
 Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr12_+_74297474 4.829 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr12_+_37880700 4.815 ENSMUST00000040500.7
 Dgkb
diacylglycerol kinase, beta
chr15_-_54920115 4.336 ENSMUST00000171545.1
 Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr6_-_101377342 4.093 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr3_+_52268337 3.304 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr14_+_80000292 3.182 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr7_+_128246812 2.863 ENSMUST00000164710.1
ENSMUST00000070656.5
 Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr19_+_26753588 2.759 ENSMUST00000177116.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_+_124793061 2.684 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr7_+_128246953 2.459 ENSMUST00000167965.1
 Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr5_-_124327883 2.390 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr5_-_8997324 2.389 ENSMUST00000003720.4
 Crot
carnitine O-octanoyltransferase
chr1_-_66817536 2.291 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr5_-_124327812 2.164 ENSMUST00000184951.1
 Mphosph9
M-phase phosphoprotein 9
chr1_-_163725123 2.019 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 13.0 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
2.5 12.5 GO:0047484 regulation of response to osmotic stress(GO:0047484)
1.4 9.9 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
2.3 6.9 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.4 6.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.8 5.3 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 4.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 3.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.4 3.3 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 3.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.3 2.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 2.7 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.2 2.4 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.7 2.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.4 2.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.6 1.8 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 1.8 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 1.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 1.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.5 GO:0005901 caveola(GO:0005901)
0.0 9.6 GO:0005615 extracellular space(GO:0005615)
0.6 7.4 GO:0097449 astrocyte projection(GO:0097449)
0.0 5.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 4.6 GO:0005814 centriole(GO:0005814)
0.0 4.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 2.8 GO:0071564 npBAF complex(GO:0071564)
0.0 2.3 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 2.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.1 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.0 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.9 GO:0001772 immunological synapse(GO:0001772)
0.0 1.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 1.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 1.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.7 GO:0005903 brush border(GO:0005903)
0.0 1.5 GO:0000786 nucleosome(GO:0000786)
0.2 1.4 GO:0031415 NatA complex(GO:0031415)
0.0 1.4 GO:0031985 Golgi cisterna(GO:0031985)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.5 GO:0008565 protein transporter activity(GO:0008565)
2.5 9.9 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 8.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
2.3 6.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 6.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 5.3 GO:0048495 Roundabout binding(GO:0048495)
0.1 5.2 GO:0016414 O-octanoyltransferase activity(GO:0016414)
0.0 5.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.4 4.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 3.3 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 3.2 GO:0045296 cadherin binding(GO:0045296)
0.1 2.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 2.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.9 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.2 1.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.2 1.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.8 GO:0004677 DNA-dependent protein kinase activity(GO:0004677) 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 1.7 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)