Motif ID: Nkx2-9

Z-value: 0.764


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_566132910.557.1e-06Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_71963713 8.752 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr12_-_56536895 7.323 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr8_-_46294592 4.776 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr13_+_72632597 4.323 ENSMUST00000172353.1
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr4_-_72852622 4.289 ENSMUST00000179234.1
ENSMUST00000078617.4
 Aldoart1

aldolase 1 A, retrogene 1

chr11_+_117849223 4.157 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr10_+_88091070 4.076 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr11_+_88718442 4.011 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr3_+_122419772 3.936 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr11_+_117849286 3.751 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr6_+_66896397 3.685 ENSMUST00000043148.6
ENSMUST00000114228.1
ENSMUST00000114227.1
ENSMUST00000114226.1
ENSMUST00000114225.1
ENSMUST00000114224.1
 Gng12





guanine nucleotide binding protein (G protein), gamma 12





chr7_-_142576492 3.314 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA
chr8_+_95633500 3.099 ENSMUST00000034094.9
 Gins3
GINS complex subunit 3 (Psf3 homolog)
chr6_-_6217023 3.055 ENSMUST00000015256.8
 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr2_+_173022360 2.857 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr16_-_33380717 2.846 ENSMUST00000180923.1
 1700007L15Rik
RIKEN cDNA 1700007L15 gene
chr6_+_66896480 2.773 ENSMUST00000114222.1
 Gng12
guanine nucleotide binding protein (G protein), gamma 12
chr5_-_62765618 2.748 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_+_4925802 2.679 ENSMUST00000057612.7
 Ssc5d
scavenger receptor cysteine rich domain containing (5 domains)
chr3_-_95411176 2.447 ENSMUST00000177599.1
 Gm5070
predicted gene 5070

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 7.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
2.4 7.3 GO:0021759 globus pallidus development(GO:0021759)
0.3 4.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.3 4.5 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
1.4 4.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 3.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.3 3.3 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.8 3.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.7 2.7 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.3 2.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 2.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 2.4 GO:0016126 sterol biosynthetic process(GO:0016126)
0.8 2.3 GO:0036292 DNA rewinding(GO:0036292)
0.1 2.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.7 2.1 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.5 2.1 GO:0002339 B cell selection(GO:0002339)
0.6 1.9 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.5 1.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.3 1.8 GO:0002934 desmosome organization(GO:0002934)
0.6 1.7 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.2 GO:0005667 transcription factor complex(GO:0005667)
2.6 7.9 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 6.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 4.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 4.2 GO:0005844 polysome(GO:0005844)
0.0 2.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 2.3 GO:0043596 nuclear replication fork(GO:0043596)
0.2 2.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 2.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 2.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.1 1.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.0 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 7.9 GO:0043027 Ran GTPase binding(GO:0008536) cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.6 7.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.6 6.5 GO:0042301 phosphate ion binding(GO:0042301)
0.2 4.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 3.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.8 3.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 3.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 2.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 2.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 2.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 2.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 2.3 GO:0036310 annealing helicase activity(GO:0036310)
0.2 2.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 2.2 GO:0030246 carbohydrate binding(GO:0030246)
0.2 2.1 GO:0015643 toxic substance binding(GO:0015643)
0.1 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)