Motif ID: Nkx2-9
Z-value: 0.764
Transcription factors associated with Nkx2-9:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx2-9 | ENSMUSG00000058669.7 | Nkx2-9 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx2-9 | mm10_v2_chr12_-_56613270_56613291 | 0.55 | 7.1e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 7.3 | GO:0021759 | globus pallidus development(GO:0021759) |
1.4 | 4.1 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
1.1 | 7.9 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
0.8 | 2.3 | GO:0036292 | DNA rewinding(GO:0036292) |
0.8 | 3.1 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.7 | 2.1 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
0.7 | 2.7 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
0.6 | 1.9 | GO:0021557 | oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
0.6 | 1.7 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
0.5 | 2.1 | GO:0002339 | B cell selection(GO:0002339) |
0.5 | 1.8 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.4 | 1.3 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
0.4 | 1.2 | GO:1903225 | regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225) |
0.4 | 1.4 | GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
0.3 | 1.0 | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response(GO:1903896) |
0.3 | 4.8 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
0.3 | 1.6 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
0.3 | 3.3 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
0.3 | 1.8 | GO:0002934 | desmosome organization(GO:0002934) |
0.3 | 4.5 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
0.3 | 2.6 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.3 | 1.3 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
0.2 | 1.2 | GO:2000587 | regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
0.2 | 1.0 | GO:2000065 | negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065) |
0.2 | 0.6 | GO:2000983 | regulation of ATP citrate synthase activity(GO:2000983) negative regulation of ATP citrate synthase activity(GO:2000984) |
0.2 | 1.3 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
0.2 | 0.9 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
0.1 | 1.0 | GO:0042940 | D-amino acid transport(GO:0042940) |
0.1 | 3.9 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
0.1 | 1.2 | GO:0060539 | diaphragm development(GO:0060539) |
0.1 | 0.8 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
0.1 | 1.6 | GO:0032060 | bleb assembly(GO:0032060) |
0.1 | 1.5 | GO:0055070 | copper ion homeostasis(GO:0055070) |
0.1 | 0.5 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
0.1 | 0.2 | GO:0034310 | primary alcohol catabolic process(GO:0034310) |
0.1 | 2.2 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
0.0 | 0.2 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.0 | 2.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
0.0 | 1.5 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.0 | 2.4 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
0.0 | 0.2 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
0.0 | 0.5 | GO:0097067 | negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067) |
0.0 | 1.2 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
0.0 | 0.2 | GO:0019249 | lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) |
0.0 | 1.7 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
0.0 | 0.4 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 0.2 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
0.0 | 0.8 | GO:0007588 | excretion(GO:0007588) |
0.0 | 0.7 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
0.0 | 0.1 | GO:0048318 | axial mesoderm development(GO:0048318) |
0.0 | 0.8 | GO:0031018 | endocrine pancreas development(GO:0031018) |
0.0 | 0.6 | GO:2001222 | regulation of neuron migration(GO:2001222) |
0.0 | 0.1 | GO:1903525 | regulation of membrane tubulation(GO:1903525) |
0.0 | 0.2 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.6 | 7.9 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
0.3 | 4.3 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.3 | 2.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.2 | 0.8 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
0.2 | 2.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
0.1 | 1.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.1 | 6.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.1 | 1.3 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.1 | 0.2 | GO:0031251 | PAN complex(GO:0031251) |
0.1 | 0.4 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
0.1 | 4.2 | GO:0005844 | polysome(GO:0005844) |
0.1 | 1.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
0.1 | 2.3 | GO:0043596 | nuclear replication fork(GO:0043596) |
0.0 | 0.2 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
0.0 | 2.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 1.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.0 | 12.2 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 1.0 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 2.7 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
0.0 | 1.8 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 1.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.0 | 0.2 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 1.6 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
0.0 | 4.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.0 | 2.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.0 | 0.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.1 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.6 | 6.5 | GO:0042301 | phosphate ion binding(GO:0042301) |
0.6 | 7.3 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.4 | 1.7 | GO:0003844 | 1,4-alpha-glucan branching enzyme activity(GO:0003844) |
0.4 | 1.2 | GO:0019153 | protein-disulfide reductase (glutathione) activity(GO:0019153) |
0.3 | 2.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
0.3 | 1.8 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
0.2 | 2.1 | GO:0015643 | toxic substance binding(GO:0015643) |
0.2 | 1.5 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.2 | 2.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.2 | 0.8 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
0.2 | 4.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.2 | 7.9 | GO:0043027 | Ran GTPase binding(GO:0008536) cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.2 | 2.3 | GO:0036310 | annealing helicase activity(GO:0036310) |
0.2 | 1.6 | GO:0034711 | inhibin binding(GO:0034711) |
0.1 | 2.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
0.1 | 1.3 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
0.1 | 2.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.1 | 3.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.1 | 1.7 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.1 | 1.3 | GO:0070636 | single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694) |
0.1 | 1.0 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 0.4 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
0.1 | 0.2 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958) |
0.1 | 1.0 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.1 | 1.9 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.1 | 1.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.1 | 2.0 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.1 | 0.5 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
0.1 | 2.7 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 1.0 | GO:0070411 | I-SMAD binding(GO:0070411) |
0.0 | 0.8 | GO:0070402 | NADPH binding(GO:0070402) |
0.0 | 0.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
0.0 | 2.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.0 | 0.6 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.0 | 0.7 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.0 | 1.3 | GO:0005109 | frizzled binding(GO:0005109) |
0.0 | 0.6 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 1.5 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 1.8 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
0.0 | 1.8 | GO:0031490 | chromatin DNA binding(GO:0031490) |
0.0 | 0.1 | GO:0048019 | receptor antagonist activity(GO:0048019) |
0.0 | 2.4 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
0.0 | 0.2 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
0.0 | 2.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 1.8 | GO:0008565 | protein transporter activity(GO:0008565) |
0.0 | 0.5 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.9 | GO:0051018 | protein kinase A binding(GO:0051018) |
0.0 | 12.5 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
0.0 | 0.2 | GO:0016653 | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653) |
0.0 | 0.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
0.0 | 0.9 | GO:0019843 | rRNA binding(GO:0019843) |
0.0 | 2.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
0.0 | 3.0 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |