Motif ID: Nkx3-1

Z-value: 0.774


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 147 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_13324160 7.613 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr4_-_140774196 7.222 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV
chr9_+_78191966 6.318 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chrX_+_164269371 6.269 ENSMUST00000145412.1
ENSMUST00000033749.7
 Pir

pirin

chrX_+_100625737 5.607 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr1_-_163289214 5.035 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr4_-_132757162 4.978 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr9_-_20976762 4.373 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr9_+_72438534 4.281 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr10_-_13324250 4.206 ENSMUST00000105543.1
 Phactr2
phosphatase and actin regulator 2
chrX_-_75875101 4.127 ENSMUST00000114059.3
 Pls3
plastin 3 (T-isoform)
chr9_+_72438519 4.089 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr6_+_128362919 3.972 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr10_-_12861735 3.966 ENSMUST00000076817.4
 Utrn
utrophin
chrX_+_56454871 3.944 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr3_-_104818539 3.939 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
 Mov10



Moloney leukemia virus 10



chr8_+_114133557 3.841 ENSMUST00000073521.5
ENSMUST00000066514.6
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chrX_-_75874536 3.714 ENSMUST00000033547.7
 Pls3
plastin 3 (T-isoform)
chr17_+_56304313 3.704 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr8_+_114133635 3.699 ENSMUST00000147605.1
ENSMUST00000134593.1
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.4 GO:0070986 left/right axis specification(GO:0070986)
2.5 7.5 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.8 7.2 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.0 6.2 GO:0060348 bone development(GO:0060348)
0.2 6.1 GO:0030224 monocyte differentiation(GO:0030224)
0.8 5.9 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.8 5.6 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.7 5.0 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.4 5.0 GO:0048664 neuron fate determination(GO:0048664)
1.5 4.4 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
1.3 4.0 GO:0007525 somatic muscle development(GO:0007525)
0.5 4.0 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.2 3.9 GO:0006379 mRNA cleavage(GO:0006379)
0.2 3.7 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.4 3.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.6 3.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.4 3.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.2 3.0 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.7 2.9 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 2.8 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 8.4 GO:0005882 intermediate filament(GO:0005882)
0.2 7.8 GO:0032420 stereocilium(GO:0032420)
0.1 6.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.0 GO:0005871 kinesin complex(GO:0005871)
0.0 5.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 4.0 GO:0070938 contractile ring(GO:0070938)
0.1 3.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 3.7 GO:0000791 euchromatin(GO:0000791)
0.7 3.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 3.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 3.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 2.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 2.0 GO:0042611 MHC protein complex(GO:0042611)
0.0 2.0 GO:0005884 actin filament(GO:0005884)
0.6 1.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.5 1.9 GO:0005712 chiasma(GO:0005712)
0.6 1.8 GO:0097447 dendritic tree(GO:0097447)
0.0 1.8 GO:0016605 PML body(GO:0016605)
0.1 1.6 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.5 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 7.4 GO:0003714 transcription corepressor activity(GO:0003714)
1.2 7.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.9 7.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.3 6.8 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.5 6.3 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.6 5.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 5.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 5.0 GO:0071837 HMG box domain binding(GO:0071837)
0.2 4.0 GO:0017166 vinculin binding(GO:0017166)
0.0 3.8 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
1.2 3.7 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 3.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 3.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 3.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.5 2.9 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 2.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 2.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.7 GO:0004386 helicase activity(GO:0004386)
0.2 2.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)