Motif ID: Nkx3-2

Z-value: 0.690


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_38965515 3.767 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr1_+_172341197 3.013 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr15_-_88978958 2.915 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr15_-_56694525 2.825 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr3_+_89436736 2.772 ENSMUST00000146630.1
ENSMUST00000145753.1
 Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr11_-_101987004 2.727 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr3_-_67463828 2.676 ENSMUST00000058981.2
 Lxn
latexin
chr8_+_45885479 2.578 ENSMUST00000034053.5
 Pdlim3
PDZ and LIM domain 3
chr3_+_89436699 2.480 ENSMUST00000038942.3
ENSMUST00000130858.1
 Pbxip1

pre B cell leukemia transcription factor interacting protein 1

chr11_+_3332426 2.456 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_-_104409992 2.391 ENSMUST00000149466.1
ENSMUST00000139015.1
 D430041D05Rik

RIKEN cDNA D430041D05 gene

chr5_-_139130159 2.320 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr16_+_41532851 2.279 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr9_-_58313189 2.249 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr4_+_102421518 2.215 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_164404606 2.215 ENSMUST00000109359.1
ENSMUST00000109358.1
ENSMUST00000103103.3
 Matn4


matrilin 4


chr6_-_125494754 2.108 ENSMUST00000032492.8
 Cd9
CD9 antigen
chr4_-_120747248 2.030 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr17_+_70561739 1.840 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr2_+_10153563 1.794 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.8 3.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.9 3.4 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
1.0 3.0 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 3.0 GO:0033622 integrin activation(GO:0033622)
0.2 2.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 2.7 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 2.7 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 2.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.2 2.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 2.2 GO:0048678 response to axon injury(GO:0048678)
0.0 2.2 GO:0098792 xenophagy(GO:0098792)
0.4 2.1 GO:0030913 paranodal junction assembly(GO:0030913)
0.3 2.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 2.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.5 2.0 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.5 2.0 GO:0009597 detection of virus(GO:0009597)
0.3 1.8 GO:0070166 enamel mineralization(GO:0070166)
0.2 1.8 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 1.8 GO:0030212 hyaluronan metabolic process(GO:0030212)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0055037 recycling endosome(GO:0055037)
0.0 5.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 4.7 GO:0005874 microtubule(GO:0005874)
0.1 4.1 GO:0005581 collagen trimer(GO:0005581)
0.2 3.8 GO:0005605 basal lamina(GO:0005605)
0.2 3.0 GO:0097449 astrocyte projection(GO:0097449)
0.2 2.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.7 GO:0001772 immunological synapse(GO:0001772)
0.0 2.5 GO:0005604 basement membrane(GO:0005604)
0.0 2.5 GO:0030018 Z disc(GO:0030018)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 2.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.4 GO:0031985 Golgi cisterna(GO:0031985)
0.1 1.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0005178 integrin binding(GO:0005178)
0.1 3.8 GO:0043015 gamma-tubulin binding(GO:0043015)
1.1 3.3 GO:0043912 D-lysine oxidase activity(GO:0043912)
1.0 3.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 2.9 GO:0008565 protein transporter activity(GO:0008565)
0.9 2.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 2.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 2.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.7 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.8 2.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.0 GO:0005518 collagen binding(GO:0005518)
0.1 1.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 1.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 1.5 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.2 1.5 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 1.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 1.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)