Motif ID: Nkx6-2

Z-value: 0.809


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.435.9e-04Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_96467606 5.897 ENSMUST00000061739.8
 Pcp4
Purkinje cell protein 4
chr18_-_42899294 5.364 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr1_+_194619815 4.719 ENSMUST00000027952.5
 Plxna2
plexin A2
chr4_-_97584612 4.508 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_62664279 4.386 ENSMUST00000028257.2
 Gca
grancalcin
chr5_-_131308076 4.166 ENSMUST00000160609.1
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr4_-_97584605 4.036 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_-_131307848 3.951 ENSMUST00000086023.5
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr17_-_29888570 3.920 ENSMUST00000171691.1
 Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr1_-_126830632 3.674 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr3_+_55461758 3.166 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr6_-_144209558 3.093 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 3.082 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr1_+_66321708 2.741 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr1_+_66322102 2.643 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr15_+_99006056 2.468 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr6_-_144209448 2.248 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr4_-_91376433 2.239 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr15_+_18818895 2.227 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr10_+_106470281 2.178 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 8.4 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 7.7 GO:0021954 central nervous system neuron development(GO:0021954)
0.6 5.9 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.8 5.4 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.4 4.7 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.7 3.9 GO:0051964 negative regulation of synapse assembly(GO:0051964)
1.0 3.0 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 2.8 GO:0048240 sperm capacitation(GO:0048240)
0.3 2.4 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.3 2.2 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.5 2.0 GO:0006538 glutamate catabolic process(GO:0006538)
0.6 1.9 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 1.9 GO:0006342 chromatin silencing(GO:0006342)
0.3 1.8 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 1.7 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268)
0.0 1.6 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.1 1.5 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 1.5 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.7 1.4 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.3 1.3 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.7 5.9 GO:0005883 neurofilament(GO:0005883)
0.6 5.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 4.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 4.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.2 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 3.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.8 GO:0044291 cell-cell contact zone(GO:0044291)
0.5 2.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.3 GO:0000786 nucleosome(GO:0000786)
0.1 2.0 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.4 GO:0097440 apical dendrite(GO:0097440)
0.1 1.3 GO:0001891 phagocytic cup(GO:0001891)
0.2 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.4 8.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.7 5.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 5.4 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 5.2 GO:0005516 calmodulin binding(GO:0005516)
0.3 4.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 4.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 3.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.8 GO:0016504 peptidase activator activity(GO:0016504)
0.4 2.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 2.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 2.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 1.6 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.5 1.5 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 1.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.3 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)