Motif ID: Nkx6-3_Dbx2_Barx2
Z-value: 0.424
Transcription factors associated with Nkx6-3_Dbx2_Barx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Barx2 | ENSMUSG00000032033.10 | Barx2 |
Dbx2 | ENSMUSG00000045608.6 | Dbx2 |
Nkx6-3 | ENSMUSG00000063672.6 | Nkx6-3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Dbx2 | mm10_v2_chr15_-_95655960_95655960 | 0.36 | 5.4e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 7.7 | GO:0019532 | oxalate transport(GO:0019532) |
0.8 | 3.1 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.5 | 1.9 | GO:1901642 | purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642) |
0.4 | 2.2 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
0.4 | 5.1 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.3 | 1.3 | GO:1900170 | prolactin signaling pathway(GO:0038161) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
0.3 | 4.7 | GO:0021860 | pyramidal neuron development(GO:0021860) |
0.2 | 0.8 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.2 | 1.0 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
0.2 | 0.9 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
0.2 | 0.5 | GO:1903903 | regulation of establishment of T cell polarity(GO:1903903) |
0.1 | 1.4 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
0.1 | 0.8 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.1 | 3.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.1 | 0.7 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 1.4 | GO:0032570 | response to progesterone(GO:0032570) |
0.1 | 0.3 | GO:0042420 | dopamine catabolic process(GO:0042420) |
0.1 | 0.4 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) |
0.1 | 0.9 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
0.1 | 1.0 | GO:0033572 | transferrin transport(GO:0033572) |
0.1 | 0.3 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 0.4 | GO:0032911 | nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911) |
0.1 | 0.3 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.1 | 0.2 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.1 | 0.3 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
0.1 | 0.3 | GO:2000425 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of apoptotic cell clearance(GO:2000425) |
0.1 | 0.2 | GO:0035633 | negative regulation of epinephrine secretion(GO:0032811) maintenance of blood-brain barrier(GO:0035633) |
0.1 | 0.8 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
0.1 | 0.3 | GO:0030242 | pexophagy(GO:0030242) |
0.1 | 0.2 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.1 | 2.1 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.0 | 0.7 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.0 | 0.2 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
0.0 | 0.2 | GO:0051012 | microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856) |
0.0 | 0.4 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.0 | 0.9 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 0.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 0.4 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
0.0 | 0.2 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.0 | 0.1 | GO:0033762 | response to glucagon(GO:0033762) |
0.0 | 0.9 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.0 | 0.3 | GO:0097186 | amelogenesis(GO:0097186) |
0.0 | 0.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 0.1 | GO:0060527 | prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527) |
0.0 | 0.9 | GO:0051438 | regulation of ubiquitin-protein transferase activity(GO:0051438) |
0.0 | 0.3 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
0.0 | 0.2 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
0.0 | 0.3 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
0.0 | 0.3 | GO:0009299 | mRNA transcription(GO:0009299) |
0.0 | 0.8 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
0.0 | 0.2 | GO:0003417 | growth plate cartilage development(GO:0003417) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 0.8 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.2 | 1.4 | GO:0097524 | sperm plasma membrane(GO:0097524) |
0.2 | 4.2 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.2 | 3.1 | GO:0043205 | fibril(GO:0043205) |
0.2 | 3.2 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
0.2 | 2.1 | GO:0042581 | specific granule(GO:0042581) |
0.1 | 0.9 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.1 | 0.2 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.1 | 0.8 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.1 | 0.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.1 | 0.2 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
0.1 | 0.2 | GO:0005594 | collagen type IX trimer(GO:0005594) |
0.1 | 0.5 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.0 | 0.4 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.0 | 0.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 3.1 | GO:0030315 | T-tubule(GO:0030315) |
0.0 | 0.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.4 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
0.0 | 0.3 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.8 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 5.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 0.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
0.0 | 0.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.1 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 0.2 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 0.1 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
0.0 | 0.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 7.7 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.6 | 1.9 | GO:0015217 | ADP transmembrane transporter activity(GO:0015217) coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
0.6 | 3.1 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.6 | 2.2 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.3 | 0.8 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
0.2 | 0.6 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.2 | 4.7 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.2 | 0.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.2 | 3.2 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.2 | 0.8 | GO:0034235 | GPI anchor binding(GO:0034235) |
0.1 | 1.4 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.1 | 4.2 | GO:0030552 | cAMP binding(GO:0030552) |
0.1 | 0.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
0.1 | 0.6 | GO:0018741 | alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902) |
0.1 | 0.3 | GO:0051378 | primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378) |
0.1 | 0.3 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
0.1 | 0.9 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.1 | 0.2 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) |
0.1 | 2.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 0.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.1 | 0.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.0 | 0.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.0 | 1.0 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 1.9 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 1.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.2 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132) |
0.0 | 0.3 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.0 | 0.2 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
0.0 | 0.7 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.1 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
0.0 | 0.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.0 | 0.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 1.0 | GO:0017022 | myosin binding(GO:0017022) |
0.0 | 0.3 | GO:0035380 | C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677) |
0.0 | 0.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.3 | GO:0042056 | chemoattractant activity(GO:0042056) |
0.0 | 0.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 0.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |