Motif ID: Nr0b1

Z-value: 0.718


Transcription factors associated with Nr0b1:

Gene SymbolEntrez IDGene Name
Nr0b1 ENSMUSG00000025056.4 Nr0b1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr0b1mm10_v2_chrX_+_86191764_86191782-0.282.9e-02Click!


Activity profile for motif Nr0b1.

activity profile for motif Nr0b1


Sorted Z-values histogram for motif Nr0b1

Sorted Z-values for motif Nr0b1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr0b1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_19094594 6.194 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr5_-_99037035 4.295 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr16_-_45844303 4.151 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844228 4.051 ENSMUST00000076333.5
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr17_-_70851189 3.812 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr5_-_99037342 3.725 ENSMUST00000161490.1
 Prkg2
protein kinase, cGMP-dependent, type II
chrX_-_48034842 3.509 ENSMUST00000039026.7
 Apln
apelin
chr7_+_79500081 3.278 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr2_-_54085542 3.138 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr1_-_9700209 2.962 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr7_+_79500018 2.932 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr13_-_29984219 2.601 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr2_-_65238625 2.488 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
 Cobll1


Cobl-like 1


chr14_+_11553523 2.292 ENSMUST00000022264.6
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr2_+_30066419 2.258 ENSMUST00000067996.6
 Set
SET nuclear oncogene
chr11_+_94328242 2.173 ENSMUST00000021227.5
 Ankrd40
ankyrin repeat domain 40
chr11_+_102604370 2.005 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr8_-_105707933 1.914 ENSMUST00000013299.9
 Enkd1
enkurin domain containing 1
chr11_+_94327984 1.879 ENSMUST00000107818.2
ENSMUST00000051221.6
 Ankrd40

ankyrin repeat domain 40

chr11_-_74723829 1.692 ENSMUST00000102520.2
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr2_+_71786923 1.468 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr19_-_46039442 1.406 ENSMUST00000137771.1
 Ldb1
LIM domain binding 1
chr7_-_65371210 1.401 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chr5_-_115436508 1.387 ENSMUST00000078701.3
 4930430O22Rik
RIKEN cDNA 4930430O22 gene
chr1_+_42697146 1.292 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr17_+_29490812 1.123 ENSMUST00000024811.6
 Pim1
proviral integration site 1
chr10_-_81350389 1.117 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
 Hmg20b



high mobility group 20B



chr7_+_82867327 1.095 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr17_-_23745829 1.083 ENSMUST00000046525.8
 Kremen2
kringle containing transmembrane protein 2
chr13_-_64274879 1.077 ENSMUST00000109770.1
 Cdc14b
CDC14 cell division cycle 14B
chr13_-_106936907 1.048 ENSMUST00000080856.7
 Ipo11
importin 11
chr10_-_127666673 1.041 ENSMUST00000026469.2
 Nab2
Ngfi-A binding protein 2
chr4_-_123750236 1.015 ENSMUST00000102636.3
 Akirin1
akirin 1
chr3_+_86224665 0.926 ENSMUST00000107635.1
 Lrba
LPS-responsive beige-like anchor
chr2_+_157279065 0.874 ENSMUST00000029171.5
 Rpn2
ribophorin II
chr11_+_105181793 0.857 ENSMUST00000092537.3
ENSMUST00000015107.6
ENSMUST00000145048.1
 Tlk2


tousled-like kinase 2 (Arabidopsis)


chrX_-_145505175 0.850 ENSMUST00000143610.1
 Amot
angiomotin
chr4_-_132422484 0.799 ENSMUST00000102568.3
 Phactr4
phosphatase and actin regulator 4
chr5_+_64803513 0.765 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr18_+_35829798 0.762 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr8_-_95434869 0.758 ENSMUST00000034249.6
 Gtl3
gene trap locus 3
chr5_+_30913398 0.757 ENSMUST00000031055.5
 Emilin1
elastin microfibril interfacer 1
chr2_+_157279026 0.749 ENSMUST00000116380.2
 Rpn2
ribophorin II
chr15_-_38078842 0.720 ENSMUST00000110336.2
 Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr2_+_4718145 0.691 ENSMUST00000056914.6
 Bend7
BEN domain containing 7
chr4_-_132422394 0.656 ENSMUST00000152271.1
ENSMUST00000084170.5
 Phactr4

phosphatase and actin regulator 4

chr19_+_45015198 0.639 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr11_+_23306884 0.610 ENSMUST00000180046.1
 Usp34
ubiquitin specific peptidase 34
chr14_+_75845296 0.578 ENSMUST00000142061.1
 Tpt1
tumor protein, translationally-controlled 1
chr2_+_59160884 0.554 ENSMUST00000037903.8
 Pkp4
plakophilin 4
chr10_+_116301374 0.507 ENSMUST00000092167.5
 Ptprb
protein tyrosine phosphatase, receptor type, B
chr9_+_80165079 0.486 ENSMUST00000184480.1
 Myo6
myosin VI
chr2_+_85037448 0.482 ENSMUST00000168266.1
ENSMUST00000130729.1
 Ssrp1

structure specific recognition protein 1

chr18_-_10030017 0.467 ENSMUST00000116669.1
ENSMUST00000092096.6
 Usp14

ubiquitin specific peptidase 14

chr11_+_105181527 0.464 ENSMUST00000106941.2
 Tlk2
tousled-like kinase 2 (Arabidopsis)
chr4_+_148130883 0.461 ENSMUST00000084129.2
 Mad2l2
MAD2 mitotic arrest deficient-like 2
chr18_+_80046854 0.449 ENSMUST00000070219.7
 Pard6g
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr10_-_128589650 0.430 ENSMUST00000082059.6
 Erbb3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr17_-_84790517 0.371 ENSMUST00000112308.2
 Lrpprc
leucine-rich PPR-motif containing
chr9_+_80165013 0.353 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr1_+_140246216 0.350 ENSMUST00000119786.1
ENSMUST00000120796.1
ENSMUST00000060201.8
ENSMUST00000120709.1
 Kcnt2



potassium channel, subfamily T, member 2



chr2_-_80581380 0.331 ENSMUST00000111760.2
 Nckap1
NCK-associated protein 1
chr13_-_14063395 0.314 ENSMUST00000170957.1
 Ggps1
geranylgeranyl diphosphate synthase 1
chr17_+_34898463 0.304 ENSMUST00000114033.2
ENSMUST00000078061.6
 Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr4_-_138913915 0.303 ENSMUST00000097830.3
 Otud3
OTU domain containing 3
chr17_-_80728026 0.296 ENSMUST00000112389.2
ENSMUST00000025089.7
 Map4k3

mitogen-activated protein kinase kinase kinase kinase 3

chr5_+_110230975 0.294 ENSMUST00000031474.7
ENSMUST00000086674.5
 Ankle2

ankyrin repeat and LEM domain containing 2

chr11_+_23306910 0.276 ENSMUST00000137823.1
 Usp34
ubiquitin specific peptidase 34
chr11_+_50237002 0.252 ENSMUST00000180443.1
 Gm26542
predicted gene, 26542
chr10_+_90829409 0.251 ENSMUST00000182202.1
ENSMUST00000182966.1
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr10_+_90829538 0.241 ENSMUST00000179694.2
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr3_-_107458895 0.221 ENSMUST00000009617.8
 Kcnc4
potassium voltage gated channel, Shaw-related subfamily, member 4
chr2_-_80581234 0.217 ENSMUST00000028386.5
 Nckap1
NCK-associated protein 1
chr11_+_107547925 0.204 ENSMUST00000100305.1
ENSMUST00000075012.1
ENSMUST00000106746.1
 Helz


helicase with zinc finger domain


chr2_+_129198757 0.203 ENSMUST00000028880.3
 Slc20a1
solute carrier family 20, member 1
chr5_+_121711609 0.175 ENSMUST00000051950.7
 Atxn2
ataxin 2
chr14_+_70457447 0.174 ENSMUST00000003561.3
 Phyhip
phytanoyl-CoA hydroxylase interacting protein
chr4_-_129696817 0.169 ENSMUST00000102588.3
 Tmem39b
transmembrane protein 39b
chr4_-_135971894 0.162 ENSMUST00000105852.1
 Lypla2
lysophospholipase 2
chr15_+_80711292 0.160 ENSMUST00000067689.7
 Tnrc6b
trinucleotide repeat containing 6b
chr16_+_44173239 0.132 ENSMUST00000119746.1
 Gm608
predicted gene 608
chr1_+_162570687 0.120 ENSMUST00000050010.4
ENSMUST00000150040.1
 Vamp4

vesicle-associated membrane protein 4

chr15_+_35371498 0.087 ENSMUST00000048646.7
 Vps13b
vacuolar protein sorting 13B (yeast)
chr8_-_85080679 0.063 ENSMUST00000093357.5
 Wdr83
WD repeat domain containing 83

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.7 8.0 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.5 2.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.5 6.2 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.5 3.5 GO:0051461 positive regulation of heat generation(GO:0031652) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.4 1.3 GO:0072070 loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.4 2.0 GO:0007223 muscular septum morphogenesis(GO:0003150) Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.4 1.5 GO:0035878 nail development(GO:0035878)
0.4 1.5 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.4 1.4 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.3 1.7 GO:0051661 maintenance of centrosome location(GO:0051661) regulation of microtubule motor activity(GO:2000574)
0.3 2.5 GO:0051639 actin filament network formation(GO:0051639)
0.3 1.1 GO:0072697 protein localization to cell cortex(GO:0072697)
0.2 0.7 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.2 3.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.2 0.5 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.2 1.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.2 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 1.0 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 0.6 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1 1.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 0.5 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 1.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 0.3 GO:0036166 phenotypic switching(GO:0036166)
0.1 0.3 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 1.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.4 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1 1.1 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 0.8 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.5 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.1 0.2 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 2.4 GO:1901998 toxin transport(GO:1901998)
0.0 0.5 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.9 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 2.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 3.1 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0006817 phosphate ion transport(GO:0006817)
0.0 0.8 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.3 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.2 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.2 GO:0045180 basal cortex(GO:0045180)
0.3 1.7 GO:0000235 astral microtubule(GO:0000235)
0.3 1.1 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.2 1.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.5 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.9 GO:0000124 SAGA complex(GO:0000124)
0.1 0.6 GO:0045298 tubulin complex(GO:0045298)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 10.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 1.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.3 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.0 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.5 1.5 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.4 3.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 1.9 GO:0038132 neuregulin binding(GO:0038132)
0.3 0.9 GO:0043532 angiostatin binding(GO:0043532)
0.3 1.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 1.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 3.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 3.8 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.4 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.3 GO:0048045 4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.1 2.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 1.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 2.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.9 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 4.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 2.5 GO:0001047 core promoter binding(GO:0001047)