Motif ID: Nr1h2

Z-value: 1.139


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.751.1e-11Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_97417730 20.667 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr4_-_53159885 19.720 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr6_+_90462562 15.617 ENSMUST00000032174.5
 Klf15
Kruppel-like factor 15
chr8_-_84773381 13.968 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr10_-_109823585 11.207 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr11_+_55098104 9.543 ENSMUST00000000608.7
 Gm2a
GM2 ganglioside activator protein
chr1_-_164458345 8.804 ENSMUST00000027863.7
 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_+_102658640 8.659 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_+_97453204 8.267 ENSMUST00000050732.7
ENSMUST00000121987.1
 Kctd14

potassium channel tetramerisation domain containing 14

chr7_+_112953955 7.176 ENSMUST00000182858.1
 Rassf10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr5_+_123015010 6.044 ENSMUST00000121652.1
ENSMUST00000051016.4
 Orai1

ORAI calcium release-activated calcium modulator 1

chr2_-_113829069 5.987 ENSMUST00000024005.7
 Scg5
secretogranin V
chr17_-_79715034 5.974 ENSMUST00000024894.1
 Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr3_+_62419668 5.921 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr5_-_120588613 5.258 ENSMUST00000046426.8
 Tpcn1
two pore channel 1
chr7_-_27446599 5.161 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr5_-_124327883 5.051 ENSMUST00000031344.6
 Mphosph9
M-phase phosphoprotein 9
chr3_+_90514435 4.872 ENSMUST00000048138.6
ENSMUST00000181271.1
 S100a13

S100 calcium binding protein A13

chr5_-_100159261 4.479 ENSMUST00000139520.1
 Tmem150c
transmembrane protein 150C
chr5_+_107331157 4.462 ENSMUST00000031215.8
ENSMUST00000112677.3
 Brdt

bromodomain, testis-specific


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 20.7 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
4.9 19.7 GO:0055099 regulation of Cdc42 protein signal transduction(GO:0032489) response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
1.1 15.6 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
1.0 14.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 10.1 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
1.9 9.5 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
2.9 8.8 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 8.8 GO:0010508 positive regulation of autophagy(GO:0010508)
1.4 8.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
2.0 6.0 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.4 6.0 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 6.0 GO:0016486 peptide hormone processing(GO:0016486)
0.3 5.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.9 5.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.6 4.9 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
1.6 4.7 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.3 4.5 GO:0007141 male meiosis I(GO:0007141)
0.7 4.3 GO:0002317 plasma cell differentiation(GO:0002317)
1.4 4.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.2 4.0 GO:0030575 nuclear body organization(GO:0030575)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 27.5 GO:0005829 cytosol(GO:0005829)
1.1 19.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 18.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 13.5 GO:0005776 autophagosome(GO:0005776)
0.0 9.1 GO:0005635 nuclear envelope(GO:0005635)
1.3 8.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 8.7 GO:0030673 axolemma(GO:0030673)
0.0 6.7 GO:0030141 secretory granule(GO:0030141)
0.9 5.2 GO:0008091 spectrin(GO:0008091)
0.1 4.7 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.5 4.0 GO:0042382 paraspeckles(GO:0042382)
0.0 4.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.7 2.9 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.6 2.6 GO:0001533 cornified envelope(GO:0001533)
0.2 2.5 GO:0043196 varicosity(GO:0043196)
0.6 2.4 GO:0045098 type III intermediate filament(GO:0045098)
0.4 2.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.3 2.0 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.5 1.8 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.6 19.7 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188)
0.0 18.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 11.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 11.2 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
1.9 9.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.9 8.8 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
2.2 8.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.2 6.0 GO:0070330 aromatase activity(GO:0070330)
0.5 6.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 6.0 GO:0051082 unfolded protein binding(GO:0051082)
0.1 5.9 GO:0051213 dioxygenase activity(GO:0051213)
1.8 5.3 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 5.2 GO:0030506 ankyrin binding(GO:0030506)
0.8 4.9 GO:0050786 RAGE receptor binding(GO:0050786)
1.6 4.7 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.2 4.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
1.4 4.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 4.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 3.9 GO:0030246 carbohydrate binding(GO:0030246)
0.3 3.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)