Motif ID: Nr2e3

Z-value: 1.314


Transcription factors associated with Nr2e3:

Gene SymbolEntrez IDGene Name
Nr2e3 ENSMUSG00000032292.2 Nr2e3



Activity profile for motif Nr2e3.

activity profile for motif Nr2e3


Sorted Z-values histogram for motif Nr2e3

Sorted Z-values for motif Nr2e3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e3

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 24.495 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr18_-_35215008 21.015 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr3_+_76074270 13.850 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr2_+_124610278 11.420 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr1_+_19103022 11.134 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr12_+_88953399 11.089 ENSMUST00000057634.7
 Nrxn3
neurexin III
chr3_+_54156039 10.311 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr1_+_185454803 10.000 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chrX_-_143933204 9.226 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr10_-_109764840 8.816 ENSMUST00000163071.1
 Nav3
neuron navigator 3
chr5_+_19227046 8.456 ENSMUST00000088516.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_+_19907502 8.297 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_-_13839916 8.269 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr18_-_22850738 8.236 ENSMUST00000092015.4
ENSMUST00000069215.6
 Nol4

nucleolar protein 4

chr2_-_45112890 8.051 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr16_-_52454074 8.036 ENSMUST00000023312.7
 Alcam
activated leukocyte cell adhesion molecule
chr1_+_143640664 7.948 ENSMUST00000038252.2
 B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr5_+_19907774 7.870 ENSMUST00000115267.2
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_+_90576570 7.819 ENSMUST00000182786.1
ENSMUST00000182600.1
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chrX_+_166344692 7.613 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 32.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
3.1 24.6 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
2.4 24.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.9 22.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.9 16.5 GO:0021860 pyramidal neuron development(GO:0021860)
1.2 11.6 GO:0042447 hormone catabolic process(GO:0042447)
0.6 11.1 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.3 11.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 11.1 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.4 10.5 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 10.4 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.5 10.3 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
1.1 10.0 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 8.3 GO:0008045 motor neuron axon guidance(GO:0008045)
1.3 8.1 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 8.0 GO:0097320 membrane tubulation(GO:0097320)
1.6 7.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.6 7.9 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
1.1 7.6 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 6.5 GO:0036465 synaptic vesicle recycling(GO:0036465)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 63.9 GO:0045211 postsynaptic membrane(GO:0045211)
4.9 24.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 19.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 14.9 GO:0005874 microtubule(GO:0005874)
0.3 13.1 GO:0042734 presynaptic membrane(GO:0042734)
0.2 11.6 GO:0005811 lipid particle(GO:0005811)
0.2 10.3 GO:0034704 calcium channel complex(GO:0034704)
0.0 8.4 GO:0005635 nuclear envelope(GO:0005635)
0.7 8.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.5 8.0 GO:0042101 T cell receptor complex(GO:0042101)
0.7 7.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 6.9 GO:0016324 apical plasma membrane(GO:0016324)
0.1 6.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 5.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 5.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.8 5.4 GO:0071437 invadopodium(GO:0071437)
1.8 5.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.6 4.3 GO:0005638 lamin filament(GO:0005638)
0.1 4.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.1 GO:0035097 histone methyltransferase complex(GO:0035097)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 32.9 GO:0046875 ephrin receptor binding(GO:0046875)
4.1 24.6 GO:0070699 type II activin receptor binding(GO:0070699)
6.1 24.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.2 22.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.9 21.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 18.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.7 11.6 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.3 11.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 11.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 10.3 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.4 10.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 9.4 GO:0008017 microtubule binding(GO:0008017)
0.3 9.3 GO:0070412 R-SMAD binding(GO:0070412)
0.7 8.6 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.3 8.1 GO:0042805 actinin binding(GO:0042805)
1.0 7.9 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.2 7.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 7.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 5.7 GO:0031402 sodium ion binding(GO:0031402)
0.1 5.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)