Motif ID: Nr2f1_Nr4a1

Z-value: 1.638

Transcription factors associated with Nr2f1_Nr4a1:

Gene SymbolEntrez IDGene Name
Nr2f1 ENSMUSG00000069171.7 Nr2f1
Nr4a1 ENSMUSG00000023034.6 Nr4a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a1mm10_v2_chr15_+_101266839_101266859-0.349.2e-03Click!
Nr2f1mm10_v2_chr13_-_78196373_78196440-0.211.1e-01Click!


Activity profile for motif Nr2f1_Nr4a1.

activity profile for motif Nr2f1_Nr4a1


Sorted Z-values histogram for motif Nr2f1_Nr4a1

Sorted Z-values for motif Nr2f1_Nr4a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f1_Nr4a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_119578981 22.821 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr1_+_12718496 18.641 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr1_+_166254095 16.382 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr11_+_70657196 14.999 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr18_+_57142782 14.143 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr11_+_70657687 13.487 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr10_+_128194446 12.919 ENSMUST00000044776.6
 Gls2
glutaminase 2 (liver, mitochondrial)
chr5_+_111581422 12.367 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chrX_+_153006461 12.139 ENSMUST00000095755.3
 Usp51
ubiquitin specific protease 51
chr4_+_99955715 12.134 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr3_-_138131356 12.070 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr7_-_109616548 11.042 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr8_-_105471481 11.029 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr11_-_100822525 10.767 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr6_-_119544282 10.381 ENSMUST00000119369.1
ENSMUST00000178696.1
 Wnt5b

wingless-related MMTV integration site 5B

chr13_+_98354234 10.247 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr9_-_54661666 10.227 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr3_+_146500071 10.179 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr13_-_74350206 10.137 ENSMUST00000022062.7
 Sdha
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr12_-_110978981 9.864 ENSMUST00000135131.1
ENSMUST00000043459.6
ENSMUST00000128353.1
 Ankrd9


ankyrin repeat domain 9



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 369 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.7 26.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
7.6 22.8 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during SA node cell action potential(GO:0086046)
0.3 22.8 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.4 21.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
6.3 18.9 GO:0042822 vitamin B6 metabolic process(GO:0042816) pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.6 16.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 16.3 GO:0006006 glucose metabolic process(GO:0006006)
0.4 16.2 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.6 15.5 GO:0016578 histone deubiquitination(GO:0016578)
0.3 14.9 GO:0051384 response to glucocorticoid(GO:0051384)
2.4 14.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
2.8 14.1 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
1.5 13.5 GO:0006105 succinate metabolic process(GO:0006105)
2.5 12.5 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
2.1 12.4 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
2.4 11.9 GO:0006543 glutamine catabolic process(GO:0006543)
0.7 11.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.7 11.0 GO:0045204 MAPK export from nucleus(GO:0045204)
3.6 10.8 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.9 10.4 GO:0033572 transferrin transport(GO:0033572)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 176 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 39.3 GO:0005667 transcription factor complex(GO:0005667)
0.2 32.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 25.7 GO:0005730 nucleolus(GO:0005730)
0.1 25.4 GO:0031012 extracellular matrix(GO:0031012)
5.1 25.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 22.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.5 21.8 GO:0098803 respiratory chain complex(GO:0098803)
0.3 20.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
1.2 19.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 18.9 GO:0016605 PML body(GO:0016605)
0.0 15.2 GO:0005654 nucleoplasm(GO:0005654)
4.7 14.2 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.9 14.0 GO:0031528 microvillus membrane(GO:0031528)
0.3 14.0 GO:0000793 condensed chromosome(GO:0000793)
1.2 13.9 GO:0000124 SAGA complex(GO:0000124)
0.2 13.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 13.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
2.5 12.4 GO:0005861 troponin complex(GO:0005861)
0.9 10.8 GO:0070069 cytochrome complex(GO:0070069)
1.3 10.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 261 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.4 26.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
2.8 25.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 24.3 GO:0001047 core promoter binding(GO:0001047)
0.6 23.4 GO:0005109 frizzled binding(GO:0005109)
3.9 19.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
2.7 19.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
6.3 18.9 GO:0031403 lithium ion binding(GO:0031403)
0.1 18.2 GO:0003924 GTPase activity(GO:0003924)
0.1 14.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.3 14.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
4.5 13.5 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.4 13.0 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
1.0 12.8 GO:0008301 DNA binding, bending(GO:0008301)
4.1 12.4 GO:0030172 troponin C binding(GO:0030172)
0.1 12.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.0 12.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 12.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
2.4 11.9 GO:0004359 glutaminase activity(GO:0004359)
0.1 11.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.5 11.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)