Motif ID: Nr4a3

Z-value: 0.419


Transcription factors associated with Nr4a3:

Gene SymbolEntrez IDGene Name
Nr4a3 ENSMUSG00000028341.3 Nr4a3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48045144_480451600.445.5e-04Click!


Activity profile for motif Nr4a3.

activity profile for motif Nr4a3


Sorted Z-values histogram for motif Nr4a3

Sorted Z-values for motif Nr4a3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_124793013 2.141 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 2.124 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chrY_-_1245685 1.823 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr5_+_66968559 1.810 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr5_+_66968416 1.557 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr11_-_55033398 1.191 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chrY_-_1245753 1.177 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr16_+_10545390 1.119 ENSMUST00000115827.1
ENSMUST00000038145.6
ENSMUST00000150894.1
 Clec16a


C-type lectin domain family 16, member A


chr17_-_35909626 1.099 ENSMUST00000141132.1
 Atat1
alpha tubulin acetyltransferase 1
chr11_+_113619318 0.959 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr7_-_98162318 0.939 ENSMUST00000107112.1
 Capn5
calpain 5
chr17_-_35910032 0.907 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr16_-_4523056 0.881 ENSMUST00000090500.3
ENSMUST00000023161.7
 Srl

sarcalumenin

chr9_-_64341145 0.833 ENSMUST00000120760.1
ENSMUST00000168844.2
 Dis3l

DIS3 mitotic control homolog (S. cerevisiae)-like

chr15_-_76918010 0.777 ENSMUST00000048854.7
 Zfp647
zinc finger protein 647
chr6_-_113531575 0.754 ENSMUST00000032425.5
 Emc3
ER membrane protein complex subunit 3
chr15_-_79804717 0.718 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr19_+_44989073 0.704 ENSMUST00000026225.8
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr7_+_45897429 0.676 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr11_+_116657106 0.671 ENSMUST00000116318.2
 Gm11744
predicted gene 11744
chr7_+_45896941 0.658 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr19_-_45998479 0.653 ENSMUST00000045396.7
 9130011E15Rik
RIKEN cDNA 9130011E15 gene
chr11_-_115267236 0.643 ENSMUST00000106554.1
 Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
chr15_+_100761741 0.612 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr12_-_93929102 0.611 ENSMUST00000180321.1
 Gm9726
predicted gene 9726
chr19_-_37207293 0.589 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr19_+_46152505 0.552 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr16_+_10545339 0.551 ENSMUST00000066345.7
ENSMUST00000115824.3
ENSMUST00000155633.1
 Clec16a


C-type lectin domain family 16, member A


chr11_+_115475645 0.537 ENSMUST00000035240.6
 Armc7
armadillo repeat containing 7
chr4_+_116075269 0.537 ENSMUST00000030471.8
 Lrrc41
leucine rich repeat containing 41
chr11_-_61494173 0.535 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
 Mapk7


mitogen-activated protein kinase 7


chr19_-_4334001 0.525 ENSMUST00000176653.1
 Kdm2a
lysine (K)-specific demethylase 2A
chr18_-_60624304 0.510 ENSMUST00000097566.3
 Synpo
synaptopodin
chr2_+_92375306 0.504 ENSMUST00000028650.8
 Pex16
peroxisomal biogenesis factor 16
chr7_-_79842287 0.503 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr8_+_119862239 0.496 ENSMUST00000034287.8
 Klhl36
kelch-like 36
chr2_-_167492826 0.485 ENSMUST00000109211.2
ENSMUST00000057627.9
 Spata2

spermatogenesis associated 2

chr4_-_43578824 0.466 ENSMUST00000030189.7
 Gba2
glucosidase beta 2
chr7_+_102267795 0.462 ENSMUST00000033289.4
 Stim1
stromal interaction molecule 1
chr9_-_22085391 0.450 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
 Ecsit



ECSIT homolog (Drosophila)



chr6_-_137571007 0.441 ENSMUST00000100841.2
 Eps8
epidermal growth factor receptor pathway substrate 8
chr3_-_59210881 0.424 ENSMUST00000040622.1
 P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr1_+_75435930 0.424 ENSMUST00000037796.7
ENSMUST00000113584.1
ENSMUST00000145166.1
ENSMUST00000143730.1
ENSMUST00000133418.1
ENSMUST00000144874.1
ENSMUST00000140287.1
 Gmppa






GDP-mannose pyrophosphorylase A






chr14_-_21848924 0.405 ENSMUST00000124549.1
 Comtd1
catechol-O-methyltransferase domain containing 1
chr2_+_178141920 0.396 ENSMUST00000103066.3
 Phactr3
phosphatase and actin regulator 3
chr9_+_22003035 0.385 ENSMUST00000115331.2
ENSMUST00000003493.7
 Prkcsh

protein kinase C substrate 80K-H

chr7_+_30712209 0.361 ENSMUST00000005692.6
ENSMUST00000170371.1
 Atp4a

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

chr2_-_180273488 0.351 ENSMUST00000108891.1
 Cables2
CDK5 and Abl enzyme substrate 2
chr4_+_43578921 0.342 ENSMUST00000030190.8
 Rgp1
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chr11_+_70764209 0.338 ENSMUST00000060444.5
 Zfp3
zinc finger protein 3
chr15_-_79141197 0.309 ENSMUST00000169604.1
 1700088E04Rik
RIKEN cDNA 1700088E04 gene
chr2_-_165283599 0.307 ENSMUST00000155289.1
 Slc35c2
solute carrier family 35, member C2
chrX_+_73675500 0.306 ENSMUST00000171398.1
 Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr4_+_131873608 0.293 ENSMUST00000053819.3
 Srsf4
serine/arginine-rich splicing factor 4
chr17_+_34605855 0.282 ENSMUST00000037489.8
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr3_-_89773221 0.262 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr15_-_102516806 0.256 ENSMUST00000169162.1
ENSMUST00000023812.2
ENSMUST00000165174.1
ENSMUST00000169367.1
ENSMUST00000169377.1
 Map3k12




mitogen-activated protein kinase kinase kinase 12




chrX_-_71492799 0.249 ENSMUST00000037391.5
ENSMUST00000114586.2
ENSMUST00000114587.2
 Cd99l2


CD99 antigen-like 2


chr6_-_28421680 0.242 ENSMUST00000090511.3
 Gcc1
golgi coiled coil 1
chr4_-_116075022 0.229 ENSMUST00000050580.4
ENSMUST00000078676.5
 Uqcrh

ubiquinol-cytochrome c reductase hinge protein

chr2_-_33468493 0.209 ENSMUST00000113156.1
ENSMUST00000028125.5
ENSMUST00000126442.1
 Zbtb43


zinc finger and BTB domain containing 43


chr4_-_150914401 0.196 ENSMUST00000105675.1
 Park7
Parkinson disease (autosomal recessive, early onset) 7
chr4_-_139131058 0.174 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr7_-_28598140 0.166 ENSMUST00000108283.1
ENSMUST00000040531.8
 Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr4_+_134397380 0.147 ENSMUST00000105870.1
 Pafah2
platelet-activating factor acetylhydrolase 2
chr7_-_19715395 0.140 ENSMUST00000032555.9
ENSMUST00000093552.5
 Tomm40

translocase of outer mitochondrial membrane 40 homolog (yeast)

chr12_+_4082574 0.138 ENSMUST00000020986.7
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr6_-_112946754 0.126 ENSMUST00000113169.2
 Srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr7_-_126475082 0.118 ENSMUST00000032978.6
 Sh2b1
SH2B adaptor protein 1
chrX_+_101299143 0.118 ENSMUST00000118111.1
ENSMUST00000130555.1
ENSMUST00000151528.1
 Nlgn3


neuroligin 3


chr4_+_134396320 0.109 ENSMUST00000105869.2
 Pafah2
platelet-activating factor acetylhydrolase 2
chr2_-_163417092 0.104 ENSMUST00000127038.1
 Oser1
oxidative stress responsive serine rich 1
chr2_+_68117713 0.081 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr8_-_120668121 0.081 ENSMUST00000034277.7
 Emc8
ER membrane protein complex subunit 8
chr4_-_126202583 0.076 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
 Thrap3


thyroid hormone receptor associated protein 3


chr8_-_120668058 0.070 ENSMUST00000181950.1
ENSMUST00000181333.1
 Emc8
Gm27021
ER membrane protein complex subunit 8
predicted gene, 27021
chr13_-_41847482 0.055 ENSMUST00000072012.3
 Adtrp
androgen dependent TFPI regulating protein
chr6_+_41546730 0.051 ENSMUST00000103299.1
 Trbc2
T cell receptor beta, constant 2
chr2_+_158794807 0.049 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
 Dhx35


DEAH (Asp-Glu-Ala-His) box polypeptide 35


chr8_-_123894736 0.028 ENSMUST00000034453.4
 Acta1
actin, alpha 1, skeletal muscle
chr7_+_130865835 0.025 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chrX_+_101299207 0.022 ENSMUST00000065858.2
 Nlgn3
neuroligin 3
chrX_+_56447965 0.020 ENSMUST00000079663.6
 Gm2174
predicted gene 2174

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.3 2.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.3 0.9 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.3 1.7 GO:1901524 regulation of autophagosome maturation(GO:1901096) regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525)
0.2 0.6 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.2 0.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 0.6 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 0.5 GO:0070375 ERK5 cascade(GO:0070375)
0.2 4.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 1.0 GO:0030432 peristalsis(GO:0030432)
0.1 0.5 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 0.5 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.1 0.5 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.1 0.3 GO:0015786 UDP-glucose transport(GO:0015786)
0.1 0.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 0.5 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.1 0.2 GO:0050787 glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) glyoxal catabolic process(GO:1903190) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) positive regulation of androgen receptor activity(GO:2000825)
0.1 1.2 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.5 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.4 GO:0036376 sodium ion export from cell(GO:0036376)
0.0 0.1 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.6 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.6 GO:0001964 startle response(GO:0001964)
0.0 3.6 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.7 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 0.4 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.3 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0097427 microtubule bundle(GO:0097427)
0.2 0.5 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.9 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.2 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.7 GO:0010008 endosome membrane(GO:0010008)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 1.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 0.7 GO:0001847 opsonin receptor activity(GO:0001847)
0.2 0.5 GO:0004348 glucosylceramidase activity(GO:0004348)
0.1 0.8 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.2 GO:0044388 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) small protein activating enzyme binding(GO:0044388) cupric ion binding(GO:1903135) cuprous ion binding(GO:1903136) glyoxalase (glycolic acid-forming) activity(GO:1990422)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.0 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)