Motif ID: Nr6a1

Z-value: 0.513


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_389264540.274.1e-02Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_66427469 2.807 ENSMUST00000015278.7
 Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr7_+_30314810 2.790 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr1_+_131970589 1.945 ENSMUST00000027695.6
 Slc45a3
solute carrier family 45, member 3
chr4_-_45530330 1.937 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr2_+_172472512 1.881 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr5_-_137610626 1.770 ENSMUST00000142675.1
 Pcolce
procollagen C-endopeptidase enhancer protein
chr13_-_24761440 1.595 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr6_+_83349446 1.584 ENSMUST00000136501.1
 Bola3
bolA-like 3 (E. coli)
chr11_-_60811228 1.477 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr5_-_137611372 1.452 ENSMUST00000054564.6
 Pcolce
procollagen C-endopeptidase enhancer protein
chr12_+_3807017 1.442 ENSMUST00000020991.8
ENSMUST00000172509.1
 Dnmt3a

DNA methyltransferase 3A

chr10_+_128083273 1.387 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr5_-_137611429 1.349 ENSMUST00000031731.7
 Pcolce
procollagen C-endopeptidase enhancer protein
chr9_+_50603892 1.336 ENSMUST00000044051.4
 Timm8b
translocase of inner mitochondrial membrane 8B
chr12_-_115790884 1.180 ENSMUST00000081809.5
 Ighv1-73
immunoglobulin heavy variable 1-73
chr12_+_3807076 1.177 ENSMUST00000174817.1
 Dnmt3a
DNA methyltransferase 3A
chr2_+_180071793 1.172 ENSMUST00000108901.1
 Mtg2
mitochondrial ribosome associated GTPase 2
chr9_-_96437434 1.154 ENSMUST00000070500.2
 BC043934
cDNA sequence BC043934
chr14_+_58072686 1.119 ENSMUST00000022545.7
 Fgf9
fibroblast growth factor 9
chr15_-_98165613 1.095 ENSMUST00000143400.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr18_-_77767752 1.019 ENSMUST00000048192.7
 Haus1
HAUS augmin-like complex, subunit 1
chr17_+_26123514 1.002 ENSMUST00000025014.8
 Mrpl28
mitochondrial ribosomal protein L28
chr5_-_30073554 1.002 ENSMUST00000026846.6
 Tyms
thymidylate synthase
chr4_+_123904832 0.993 ENSMUST00000030400.7
 Mycbp
c-myc binding protein
chr11_-_69822144 0.972 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr8_+_75109528 0.969 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr10_-_80855187 0.966 ENSMUST00000035775.8
 Lsm7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr7_-_105574324 0.956 ENSMUST00000081165.7
 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr1_+_151428612 0.955 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr12_-_71136611 0.931 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chr3_+_138526174 0.927 ENSMUST00000029803.7
 Eif4e
eukaryotic translation initiation factor 4E
chr19_+_46707443 0.925 ENSMUST00000003655.7
 As3mt
arsenic (+3 oxidation state) methyltransferase
chr14_+_12189943 0.922 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr11_+_6560183 0.875 ENSMUST00000109722.2
 Ccm2
cerebral cavernous malformation 2
chr15_-_98165560 0.825 ENSMUST00000123922.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr17_-_46645128 0.770 ENSMUST00000003642.6
 Klc4
kinesin light chain 4
chr9_-_50603792 0.769 ENSMUST00000000175.4
 Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
chr9_+_98296556 0.743 ENSMUST00000035031.6
ENSMUST00000112935.1
 Nmnat3

nicotinamide nucleotide adenylyltransferase 3

chr4_+_123904907 0.718 ENSMUST00000106202.3
 Mycbp
c-myc binding protein
chr8_-_109693235 0.696 ENSMUST00000034164.4
 Ist1
increased sodium tolerance 1 homolog (yeast)
chr15_-_73184840 0.659 ENSMUST00000044113.10
 Ago2
argonaute RISC catalytic subunit 2
chr6_+_42245907 0.653 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr2_+_173737492 0.521 ENSMUST00000067530.4
 Vapb
vesicle-associated membrane protein, associated protein B and C
chr10_-_43540945 0.500 ENSMUST00000147196.1
ENSMUST00000019932.3
 1700021F05Rik

RIKEN cDNA 1700021F05 gene

chr1_-_151428440 0.472 ENSMUST00000064771.5
 Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr4_+_13743424 0.459 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr5_-_136986829 0.452 ENSMUST00000034953.7
ENSMUST00000085941.5
 Znhit1

zinc finger, HIT domain containing 1

chr17_+_72918298 0.444 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr9_-_121839460 0.435 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chr9_+_73102398 0.409 ENSMUST00000174203.2
ENSMUST00000034737.6
ENSMUST00000173734.2
ENSMUST00000167514.1
 Gm20509
Khdc3


predicted gene 20509
KH domain containing 3, subcortical maternal complex member


chr4_-_134552122 0.372 ENSMUST00000060435.6
 Sepn1
selenoprotein N, 1
chr2_+_157424255 0.368 ENSMUST00000029175.7
ENSMUST00000092576.4
 Src

Rous sarcoma oncogene

chr4_+_155562348 0.337 ENSMUST00000030939.7
 Nadk
NAD kinase
chr11_+_120677226 0.312 ENSMUST00000129644.2
ENSMUST00000151160.1
 Aspscr1

alveolar soft part sarcoma chromosome region, candidate 1 (human)

chr4_+_43632185 0.299 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr17_+_33629078 0.288 ENSMUST00000166627.1
ENSMUST00000073570.5
ENSMUST00000170225.1
 Zfp414


zinc finger protein 414


chr1_+_171329376 0.237 ENSMUST00000111299.1
ENSMUST00000064950.4
 Dedd

death effector domain-containing

chr7_+_128265675 0.230 ENSMUST00000118169.1
ENSMUST00000142841.1
 Slc5a2

solute carrier family 5 (sodium/glucose cotransporter), member 2

chr2_+_32606946 0.219 ENSMUST00000113290.1
 St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr2_+_32606979 0.188 ENSMUST00000113289.1
ENSMUST00000095044.3
 St6galnac6

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

chrX_-_36991724 0.160 ENSMUST00000152291.1
 Sept6
septin 6
chr13_+_58281183 0.119 ENSMUST00000180882.1
ENSMUST00000180452.1
 Gm26555

predicted gene, 26555

chr7_+_133637543 0.106 ENSMUST00000051169.6
 2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr7_-_130772652 0.103 ENSMUST00000057134.4
 Etos1
ectopic ossification 1
chr7_-_145283915 0.085 ENSMUST00000058022.4
 Tpcn2
two pore segment channel 2
chr4_-_123904826 0.067 ENSMUST00000181292.1
 Gm26606
predicted gene, 26606
chr19_-_5688149 0.047 ENSMUST00000068169.5
 Pcnxl3
pecanex-like 3 (Drosophila)
chr5_+_136987019 0.035 ENSMUST00000004968.4
 Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr5_-_5694024 0.020 ENSMUST00000115425.2
ENSMUST00000115427.1
ENSMUST00000115424.2
ENSMUST00000015797.4
 Steap2



six transmembrane epithelial antigen of prostate 2



chr7_+_133637686 0.006 ENSMUST00000128901.2
 2700050L05Rik
RIKEN cDNA 2700050L05 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0060166 olfactory pit development(GO:0060166)
0.8 2.5 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.6 1.9 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.3 1.4 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.3 2.6 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.3 2.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.3 2.8 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.2 0.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 0.7 GO:0009838 abscission(GO:0009838)
0.2 0.7 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.5 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 0.4 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1 0.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.7 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.1 0.9 GO:0009404 toxin metabolic process(GO:0009404)
0.1 1.1 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.1 1.2 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.1 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.9 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.1 0.5 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.9 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 1.0 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.4 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 1.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.0 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.9 GO:1901998 toxin transport(GO:1901998)
0.0 1.0 GO:0030317 sperm motility(GO:0030317)
0.0 1.4 GO:0051225 spindle assembly(GO:0051225)
0.0 0.7 GO:0006749 glutathione metabolic process(GO:0006749)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 0.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.0 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.2 1.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 1.0 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 1.6 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 1.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.0 GO:0070652 HAUS complex(GO:0070652)
0.1 2.6 GO:0001741 XY body(GO:0001741)
0.1 0.7 GO:0090543 Flemming body(GO:0090543)
0.1 0.4 GO:0045179 apical cortex(GO:0045179)
0.1 1.0 GO:0042555 MCM complex(GO:0042555)
0.1 0.2 GO:0005940 septin ring(GO:0005940)
0.0 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.2 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.6 2.8 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.5 1.5 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) serine binding(GO:0070905)
0.3 2.6 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.2 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 0.8 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.2 0.7 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 1.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 4.6 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.3 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 1.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 1.0 GO:0005542 folic acid binding(GO:0005542)
0.1 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.7 GO:0015035 glutathione peroxidase activity(GO:0004602) protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.4 GO:0008932 lytic endotransglycosylase activity(GO:0008932)
0.0 1.9 GO:0030792 methylarsonite methyltransferase activity(GO:0030792)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.9 GO:0051087 chaperone binding(GO:0051087)