Motif ID: Nrf1

Z-value: 3.147


Transcription factors associated with Nrf1:

Gene SymbolEntrez IDGene Name
Nrf1 ENSMUSG00000058440.8 Nrf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nrf1mm10_v2_chr6_+_30047979_300480490.436.0e-04Click!


Activity profile for motif Nrf1.

activity profile for motif Nrf1


Sorted Z-values histogram for motif Nrf1

Sorted Z-values for motif Nrf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nrf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_79682304 13.460 ENSMUST00000166603.1
 Cdc34
cell division cycle 34
chr15_+_88751649 11.025 ENSMUST00000041297.8
 Zbed4
zinc finger, BED domain containing 4
chr10_+_79682169 9.230 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr11_-_69921329 9.107 ENSMUST00000108613.3
ENSMUST00000043419.3
ENSMUST00000070996.4
 Eif5a


eukaryotic translation initiation factor 5A


chr7_-_29281977 8.409 ENSMUST00000098604.4
ENSMUST00000108236.3
 Spint2

serine protease inhibitor, Kunitz type 2

chr14_+_59625281 8.393 ENSMUST00000053949.5
 Shisa2
shisa homolog 2 (Xenopus laevis)
chr19_+_41911851 8.360 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr2_-_157135200 8.027 ENSMUST00000109549.2
ENSMUST00000088523.4
ENSMUST00000057725.3
 Samhd1


SAM domain and HD domain, 1


chr13_-_53286052 7.905 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr2_-_157135112 7.728 ENSMUST00000139263.1
 Samhd1
SAM domain and HD domain, 1
chr11_-_33163072 7.576 ENSMUST00000093201.6
ENSMUST00000101375.4
ENSMUST00000109354.3
ENSMUST00000075641.3
 Npm1



nucleophosmin 1



chr11_-_69921190 7.517 ENSMUST00000108607.1
 Eif5a
eukaryotic translation initiation factor 5A
chr2_+_168081004 7.429 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr9_+_21616230 6.976 ENSMUST00000174008.1
 Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr7_+_24547150 6.939 ENSMUST00000063249.8
 Xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr7_+_46847128 6.915 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr11_+_50377719 6.813 ENSMUST00000069304.7
ENSMUST00000077817.7
 Hnrnph1

heterogeneous nuclear ribonucleoprotein H1

chrX_-_48513518 6.652 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr11_+_86544982 6.588 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
 Tubd1



tubulin, delta 1



chr9_+_21616166 6.519 ENSMUST00000034707.8
ENSMUST00000098948.3
 Smarca4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 613 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 34.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
3.1 21.9 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
3.6 21.7 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
2.1 20.9 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
1.7 18.9 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.8 17.5 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.4 17.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
3.9 15.8 GO:0006203 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.2 14.5 GO:0006413 translational initiation(GO:0006413)
0.7 14.2 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.5 14.1 GO:0009299 mRNA transcription(GO:0009299)
3.4 13.5 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.1 13.0 GO:0098792 xenophagy(GO:0098792)
0.3 12.5 GO:0006378 mRNA polyadenylation(GO:0006378)
1.5 12.0 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.5 11.9 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
2.2 11.0 GO:0040031 snRNA modification(GO:0040031)
0.9 10.3 GO:0000012 single strand break repair(GO:0000012)
3.1 9.4 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
2.3 9.4 GO:0006407 rRNA export from nucleus(GO:0006407)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 285 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 54.3 GO:0005730 nucleolus(GO:0005730)
0.0 29.5 GO:0005654 nucleoplasm(GO:0005654)
2.8 27.7 GO:0005642 annulate lamellae(GO:0005642)
1.4 24.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.4 24.1 GO:0005643 nuclear pore(GO:0005643)
0.5 23.1 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 22.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 19.3 GO:0000775 chromosome, centromeric region(GO:0000775)
1.7 18.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 17.1 GO:0005840 ribosome(GO:0005840)
0.5 16.0 GO:0090544 BAF-type complex(GO:0090544)
5.1 15.3 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.3 15.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 15.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 15.1 GO:0005681 spliceosomal complex(GO:0005681)
0.3 13.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 12.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 11.7 GO:0005923 bicellular tight junction(GO:0005923)
0.3 11.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 10.7 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 352 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 136.4 GO:0003723 RNA binding(GO:0003723)
0.2 40.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 31.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.5 29.3 GO:0003743 translation initiation factor activity(GO:0003743)
2.0 25.9 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.5 24.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
2.2 23.8 GO:0030957 Tat protein binding(GO:0030957)
1.8 23.4 GO:0017070 U6 snRNA binding(GO:0017070)
1.8 18.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.3 18.3 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 17.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 16.6 GO:0003684 damaged DNA binding(GO:0003684)
1.0 16.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 15.4 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.5 14.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 14.0 GO:0000049 tRNA binding(GO:0000049)
0.6 13.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 13.2 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
1.1 12.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 11.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)