Motif ID: Onecut1_Cux2

Z-value: 1.197

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.564.2e-06Click!
Cux2mm10_v2_chr5_-_122049822_122049882-0.143.1e-01Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 30.820 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_102010138 22.940 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr6_+_4755327 13.480 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr14_+_68083853 13.030 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr2_-_148046896 7.394 ENSMUST00000172928.1
ENSMUST00000047315.3
 Foxa2

forkhead box A2

chr19_-_57197496 7.204 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr12_+_55598917 6.816 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr19_-_57197377 6.707 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197435 6.227 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197556 5.222 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr2_-_168767136 5.075 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr8_-_91801547 5.022 ENSMUST00000093312.4
 Irx3
Iroquois related homeobox 3 (Drosophila)
chr9_-_114844090 4.591 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr7_+_25152456 4.156 ENSMUST00000098678.1
 D930028M14Rik
RIKEN cDNA D930028M14 gene
chr1_-_89933290 4.040 ENSMUST00000036954.7
 Gbx2
gastrulation brain homeobox 2
chr19_+_55894508 4.017 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr4_+_62965560 3.793 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr3_+_5218516 3.725 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr3_+_5218589 3.711 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr2_-_84775388 3.710 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.1 30.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 23.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.8 22.9 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 13.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
4.3 13.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.5 8.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
2.5 7.4 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
2.1 6.4 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 5.0 GO:0007498 mesoderm development(GO:0007498)
0.9 4.7 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.6 4.0 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.5 4.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.6 3.8 GO:0003383 apical constriction(GO:0003383)
0.0 3.7 GO:0006935 chemotaxis(GO:0006935) taxis(GO:0042330)
0.3 3.6 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
1.0 3.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.2 3.0 GO:0031507 heterochromatin assembly(GO:0031507)
1.0 2.9 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.3 2.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 2.9 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 97.2 GO:0005634 nucleus(GO:0005634)
0.2 25.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
4.3 13.0 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 9.2 GO:0000792 heterochromatin(GO:0000792)
0.1 6.6 GO:0072562 blood microparticle(GO:0072562)
0.4 4.7 GO:0032584 growth cone membrane(GO:0032584)
0.0 4.4 GO:0055037 recycling endosome(GO:0055037)
0.4 4.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.5 3.8 GO:0033269 internode region of axon(GO:0033269)
0.3 3.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.2 2.9 GO:0043034 costamere(GO:0043034)
0.2 2.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.9 GO:0043679 axon terminus(GO:0043679)
0.4 2.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 2.8 GO:0030426 growth cone(GO:0030426)
0.0 1.9 GO:0043296 apical junction complex(GO:0043296)
0.2 1.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.4 1.7 GO:0032127 dense core granule membrane(GO:0032127)
0.4 1.6 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 31.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 26.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 24.9 GO:0003779 actin binding(GO:0003779)
0.4 22.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 19.5 GO:0008270 zinc ion binding(GO:0008270)
0.5 13.0 GO:0043274 phospholipase binding(GO:0043274)
1.0 7.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 6.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 6.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.4 6.1 GO:0001848 complement binding(GO:0001848)
0.8 4.7 GO:0005042 netrin receptor activity(GO:0005042)
0.0 4.6 GO:0005125 cytokine activity(GO:0005125)
0.2 4.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 3.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 3.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 3.7 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 3.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 2.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 2.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 2.8 GO:1990226 histone methyltransferase binding(GO:1990226)