Motif ID: Onecut2_Onecut3

Z-value: 0.599

Transcription factors associated with Onecut2_Onecut3:

Gene SymbolEntrez IDGene Name
Onecut2 ENSMUSG00000045991.12 Onecut2
Onecut3 ENSMUSG00000045518.8 Onecut3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut2mm10_v2_chr18_+_64340225_643403640.142.8e-01Click!
Onecut3mm10_v2_chr10_+_80494835_804948730.009.9e-01Click!


Activity profile for motif Onecut2_Onecut3.

activity profile for motif Onecut2_Onecut3


Sorted Z-values histogram for motif Onecut2_Onecut3

Sorted Z-values for motif Onecut2_Onecut3



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut2_Onecut3

PNG image of the network

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Top targets:


Showing 1 to 20 of 191 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_49636847 6.814 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr6_-_23248264 6.567 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_+_109544498 3.137 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr2_-_148046896 2.879 ENSMUST00000172928.1
ENSMUST00000047315.3
 Foxa2

forkhead box A2

chr12_+_109545390 2.679 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr3_+_102010138 2.637 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr6_+_5390387 2.430 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr16_-_23890805 2.252 ENSMUST00000004480.3
 Sst
somatostatin
chr7_-_142661858 1.833 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr12_+_88083697 1.799 ENSMUST00000177720.1
 Gm16368
predicted pseudogene 16368
chr10_-_45470201 1.658 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr11_+_78499087 1.642 ENSMUST00000017488.4
 Vtn
vitronectin
chr9_+_55326913 1.580 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr10_+_69533761 1.530 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr4_+_43384332 1.517 ENSMUST00000136360.1
 Rusc2
RUN and SH3 domain containing 2
chrY_+_897782 1.445 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr9_-_69451035 1.366 ENSMUST00000071565.5
 Gm4978
predicted gene 4978
chr6_-_127769427 1.365 ENSMUST00000032500.8
 Prmt8
protein arginine N-methyltransferase 8
chr12_-_34291092 1.346 ENSMUST00000166546.2
 Gm18025
predicted gene, 18025
chr19_+_55742242 1.336 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box







Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.8 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.1 6.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 5.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.5 3.7 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 3.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.0 2.9 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 2.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.2 2.4 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 1.8 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 1.7 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 1.6 GO:0097421 liver regeneration(GO:0097421)
0.3 1.4 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.3 1.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 1.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.3 1.2 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.1 0.9 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.2 0.6 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.1 0.6 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.2 0.5 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.2 0.5 GO:1902071 regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 3.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.6 2.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 1.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.5 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.5 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.3 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0012506 vesicle membrane(GO:0012506)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 3.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.3 GO:0005179 hormone activity(GO:0005179)
0.1 1.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 1.4 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.2 1.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 1.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 0.6 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.6 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 0.5 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)