Motif ID: Otx1

Z-value: 0.460


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.411.2e-03Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_3973086 3.793 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr5_-_98566762 3.417 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr9_+_108479849 3.205 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr7_-_38271310 2.420 ENSMUST00000032585.6
 Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chrX_-_48513518 2.249 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr17_+_35861318 2.224 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr3_+_54481429 2.215 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr8_-_47675556 1.947 ENSMUST00000125536.1
 Ing2
inhibitor of growth family, member 2
chr1_-_165708088 1.924 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr11_+_94936224 1.898 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr5_-_37336870 1.879 ENSMUST00000031005.4
 Evc
Ellis van Creveld gene syndrome
chr2_-_60963192 1.866 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr5_-_37336837 1.686 ENSMUST00000114148.1
 Evc
Ellis van Creveld gene syndrome
chr12_-_46818749 1.684 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr16_-_59632520 1.667 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chr9_+_68653761 1.415 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr17_+_35861343 1.353 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr2_-_144011202 1.330 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr11_+_115564434 1.328 ENSMUST00000021085.4
 Nup85
nucleoporin 85
chr1_+_131910458 1.262 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.8 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 3.6 GO:0003416 endochondral bone growth(GO:0003416)
0.8 3.2 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 2.4 GO:0006379 mRNA cleavage(GO:0006379)
0.2 2.2 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.0 2.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 2.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 1.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 1.9 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 1.9 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.3 1.7 GO:0046909 intermembrane transport(GO:0046909)
0.0 1.7 GO:0050684 regulation of mRNA processing(GO:0050684)
0.3 1.4 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 1.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.3 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0 1.3 GO:0048246 macrophage chemotaxis(GO:0048246)
0.4 1.2 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.1 1.2 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 1.2 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.2 1.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.6 GO:0005652 nuclear lamina(GO:0005652)
0.0 3.6 GO:0036064 ciliary basal body(GO:0036064)
0.5 3.2 GO:0043256 laminin complex(GO:0043256)
0.8 2.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 2.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.0 GO:0016607 nuclear speck(GO:0016607)
0.6 1.9 GO:0005584 collagen type I trimer(GO:0005584)
0.3 1.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 1.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 1.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.4 1.2 GO:0031983 vesicle lumen(GO:0031983)
0.2 1.0 GO:0002177 manchette(GO:0002177)
0.0 1.0 GO:0051233 spindle midzone(GO:0051233)
0.0 0.9 GO:0030904 retromer complex(GO:0030904)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.8 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 3.2 GO:0005178 integrin binding(GO:0005178)
0.8 2.4 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.7 2.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 1.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.9 GO:0051015 actin filament binding(GO:0051015)
0.4 1.4 GO:0008142 oxysterol binding(GO:0008142)
0.3 1.4 GO:0005047 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.3 1.3 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.4 1.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.4 1.2 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.9 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 0.8 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)