Motif ID: Pax3

Z-value: 0.503


Transcription factors associated with Pax3:

Gene SymbolEntrez IDGene Name
Pax3 ENSMUSG00000004872.9 Pax3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax3mm10_v2_chr1_-_78197112_78197134-0.292.4e-02Click!


Activity profile for motif Pax3.

activity profile for motif Pax3


Sorted Z-values histogram for motif Pax3

Sorted Z-values for motif Pax3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_40346290 3.140 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr4_+_127077374 2.709 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr2_-_136387929 2.693 ENSMUST00000035264.2
ENSMUST00000077200.3
 Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chr10_+_82138253 2.439 ENSMUST00000105314.2
 AU041133
expressed sequence AU041133
chrX_+_159840463 2.005 ENSMUST00000112451.1
ENSMUST00000112453.2
 Sh3kbp1

SH3-domain kinase binding protein 1

chr2_+_168230597 1.948 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr14_+_51893610 1.762 ENSMUST00000047726.5
ENSMUST00000161888.1
 Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr8_+_71887264 1.662 ENSMUST00000034259.7
 Zfp709
zinc finger protein 709
chrX_-_103623648 1.652 ENSMUST00000156211.1
 Ftx
Ftx transcript, Xist regulator (non-protein coding)
chr7_+_30121915 1.549 ENSMUST00000098596.3
ENSMUST00000153792.1
 Zfp382

zinc finger protein 382

chr10_-_70592782 1.456 ENSMUST00000162251.1
 Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr12_+_52699297 1.411 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr18_+_35562158 1.389 ENSMUST00000166793.1
 Matr3
matrin 3
chr12_+_38780284 1.367 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr19_-_36736653 1.358 ENSMUST00000087321.2
 Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr12_+_38780817 1.347 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr7_+_120843551 1.263 ENSMUST00000106489.1
ENSMUST00000143279.1
 Eef2k

eukaryotic elongation factor-2 kinase

chr12_+_38781093 1.215 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr8_-_71043040 1.137 ENSMUST00000170101.1
 Gm17576
predicted gene, 17576
chrX_-_103623704 1.133 ENSMUST00000130063.1
ENSMUST00000125419.1
 Ftx

Ftx transcript, Xist regulator (non-protein coding)

chr1_+_176814660 1.125 ENSMUST00000056773.8
ENSMUST00000027785.8
 Sdccag8

serologically defined colon cancer antigen 8

chr13_+_21716385 1.024 ENSMUST00000070124.3
 Hist1h2ai
histone cluster 1, H2ai
chr3_+_36159522 0.989 ENSMUST00000165956.2
 D3Ertd254e
DNA segment, Chr 3, ERATO Doi 254, expressed
chr11_-_58323113 0.902 ENSMUST00000108829.1
 Zfp672
zinc finger protein 672
chr8_+_33428709 0.886 ENSMUST00000059351.7
 5930422O12Rik
RIKEN cDNA 5930422O12 gene
chr16_-_32877723 0.778 ENSMUST00000119810.1
 1700021K19Rik
RIKEN cDNA 1700021K19 gene
chr16_-_88056176 0.769 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
 Grik1


glutamate receptor, ionotropic, kainate 1


chr2_+_102659213 0.715 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_21691860 0.695 ENSMUST00000072133.4
 Gm10226
predicted gene 10226
chr16_+_32877775 0.659 ENSMUST00000023489.4
ENSMUST00000171325.1
 Fyttd1

forty-two-three domain containing 1

chr17_+_87107621 0.609 ENSMUST00000041369.6
 Socs5
suppressor of cytokine signaling 5
chr3_-_59262825 0.542 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chrX_+_114474312 0.501 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr3_+_108186332 0.453 ENSMUST00000050909.6
ENSMUST00000106659.2
ENSMUST00000106656.1
ENSMUST00000106661.2
 Amigo1



adhesion molecule with Ig like domain 1



chr11_-_88851462 0.393 ENSMUST00000107903.1
 Akap1
A kinase (PRKA) anchor protein 1
chr3_+_79884496 0.388 ENSMUST00000118853.1
 Fam198b
family with sequence similarity 198, member B
chr12_+_109540979 0.072 ENSMUST00000129245.1
ENSMUST00000143836.1
ENSMUST00000124106.1
 Meg3


maternally expressed 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.5 1.9 GO:0018307 enzyme active site formation(GO:0018307)
0.4 1.4 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.2 0.5 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 0.7 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.8 GO:0032229 positive regulation of gamma-aminobutyric acid secretion(GO:0014054) negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.1 3.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 0.6 GO:0071638 positive regulation of T-helper 1 cell differentiation(GO:0045627) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 1.8 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.4 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 1.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.4 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 2.7 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway(GO:2001237)
0.0 1.0 GO:0003170 heart valve development(GO:0003170)
0.0 0.5 GO:0007413 axonal fasciculation(GO:0007413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0042587 glycogen granule(GO:0042587)
0.1 0.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 1.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.5 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.4 1.9 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.2 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.4 GO:0043495 protein anchor(GO:0043495)
0.1 0.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 2.7 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 1.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)