Motif ID: Pax4

Z-value: 0.482


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_90738438 4.865 ENSMUST00000082432.3
Dio2
deiodinase, iodothyronine, type II
chr8_-_84773381 4.682 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chrX_+_9199865 4.196 ENSMUST00000069763.2
Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr15_-_79164477 3.468 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chr9_+_32696005 3.427 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1


E26 avian leukemia oncogene 1, 5' domain


chr8_-_70700070 3.270 ENSMUST00000116172.1
Gm11175
predicted gene 11175
chr15_-_88978958 2.889 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr9_-_58159201 2.849 ENSMUST00000041477.7
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr13_-_101768154 2.812 ENSMUST00000055518.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chrX_+_142227923 2.445 ENSMUST00000042329.5
Nxt2
nuclear transport factor 2-like export factor 2
chr2_-_168741898 2.420 ENSMUST00000109176.1
ENSMUST00000178504.1
Atp9a

ATPase, class II, type 9A

chr2_+_73271925 2.336 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chrX_+_142228177 2.190 ENSMUST00000112914.1
Nxt2
nuclear transport factor 2-like export factor 2
chr13_+_23738804 1.993 ENSMUST00000040914.1
Hist1h1c
histone cluster 1, H1c
chr4_-_88033328 1.927 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_-_168741752 1.902 ENSMUST00000029060.4
Atp9a
ATPase, class II, type 9A
chr5_-_103100054 1.849 ENSMUST00000112848.1
Mapk10
mitogen-activated protein kinase 10
chr4_+_136357423 1.568 ENSMUST00000182167.1
Gm17388
predicted gene, 17388
chr2_+_158667119 1.567 ENSMUST00000045503.4
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr2_+_158666690 1.496 ENSMUST00000103116.3
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr12_+_71048338 1.494 ENSMUST00000135709.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr9_-_101198999 1.485 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr9_+_58488568 1.458 ENSMUST00000085658.4
6030419C18Rik
RIKEN cDNA 6030419C18 gene
chr15_+_99006056 1.364 ENSMUST00000079818.3
Gm8973
predicted gene 8973
chr13_+_109632760 1.353 ENSMUST00000135275.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr13_-_23430826 1.319 ENSMUST00000153753.1
ENSMUST00000141543.1
C230035I16Rik

RIKEN cDNA C230035I16 gene

chr10_+_107271827 1.253 ENSMUST00000020057.8
ENSMUST00000105280.3
Lin7a

lin-7 homolog A (C. elegans)

chr11_+_62574523 1.230 ENSMUST00000018651.7
Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr10_-_64090265 1.197 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chrX_-_8206475 1.027 ENSMUST00000089403.3
ENSMUST00000077595.5
ENSMUST00000089402.3
ENSMUST00000082320.5
Porcn



porcupine homolog (Drosophila)



chr14_-_12823031 1.002 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
Cadps



Ca2+-dependent secretion activator



chr7_+_7171330 0.914 ENSMUST00000051435.7
Zfp418
zinc finger protein 418
chr10_-_64090241 0.889 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr12_-_98577940 0.870 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr19_-_32712287 0.857 ENSMUST00000070210.4
Atad1
ATPase family, AAA domain containing 1
chr18_+_53862087 0.843 ENSMUST00000069597.6
Csnk1g3
casein kinase 1, gamma 3
chr10_-_62792243 0.751 ENSMUST00000020268.5
Ccar1
cell division cycle and apoptosis regulator 1
chr13_-_66851513 0.740 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr3_+_20057802 0.735 ENSMUST00000002502.5
Hltf
helicase-like transcription factor
chrX_-_9662950 0.676 ENSMUST00000033519.2
Dynlt3
dynein light chain Tctex-type 3
chr9_-_103222063 0.601 ENSMUST00000170904.1
Trf
transferrin
chr16_+_15637844 0.556 ENSMUST00000023352.8
Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr5_-_116591811 0.507 ENSMUST00000076124.5
Srrm4
serine/arginine repetitive matrix 4
chr4_+_136284708 0.497 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr17_+_35059035 0.479 ENSMUST00000007255.6
ENSMUST00000174493.1
Ddah2

dimethylarginine dimethylaminohydrolase 2

chr6_+_47877204 0.466 ENSMUST00000061890.7
Zfp282
zinc finger protein 282
chrX_+_143518576 0.462 ENSMUST00000033640.7
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr19_-_10482874 0.436 ENSMUST00000038842.3
Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr5_+_124552845 0.381 ENSMUST00000071057.7
Ddx55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr5_-_116288978 0.374 ENSMUST00000050178.6
Ccdc60
coiled-coil domain containing 60
chr2_-_131328982 0.370 ENSMUST00000110194.1
Rnf24
ring finger protein 24
chr5_-_121502980 0.367 ENSMUST00000079368.3
Adam1b
a disintegrin and metallopeptidase domain 1b
chr2_-_33086366 0.357 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr13_+_21717626 0.347 ENSMUST00000091754.2
Hist1h3h
histone cluster 1, H3h
chr1_-_74935549 0.331 ENSMUST00000094844.3
Ccdc108
coiled-coil domain containing 108
chr10_+_119992916 0.323 ENSMUST00000105261.2
Grip1
glutamate receptor interacting protein 1
chr4_+_136284658 0.304 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr13_-_66852017 0.290 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr8_+_8689666 0.289 ENSMUST00000179702.1
B930078G14Rik
RIKEN cDNA B930078G14 gene
chrM_+_11734 0.245 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chrX_+_143518671 0.244 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr12_+_33314277 0.239 ENSMUST00000133549.1
Atxn7l1
ataxin 7-like 1
chr10_+_90071095 0.192 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr6_+_136518820 0.189 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr8_-_22476809 0.183 ENSMUST00000163774.1
ENSMUST00000033935.8
Smim19

small integral membrane protein 19

chr1_-_88008520 0.146 ENSMUST00000040783.4
Usp40
ubiquitin specific peptidase 40
chr7_-_45366714 0.116 ENSMUST00000107779.1
Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr1_-_156034800 0.108 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr4_+_150087365 0.102 ENSMUST00000094451.3
Gpr157
G protein-coupled receptor 157
chr10_-_67548944 0.086 ENSMUST00000075686.4
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr2_+_22895583 0.053 ENSMUST00000152170.1
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr15_-_50889691 0.050 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr2_-_114654943 0.043 ENSMUST00000028640.7
ENSMUST00000102542.3
Dph6

diphthamine biosynthesis 6

chr4_+_6365650 0.032 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
Sdcbp




syndecan binding protein





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.9 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.9 3.4 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.8 3.1 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.6 2.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.5 1.5 GO:0007525 somatic muscle development(GO:0007525)
0.3 4.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 1.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 3.5 GO:0048484 enteric nervous system development(GO:0048484)
0.3 2.0 GO:0016584 nucleosome positioning(GO:0016584)
0.3 2.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.3 1.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 1.5 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.2 1.9 GO:0007379 segment specification(GO:0007379)
0.1 2.1 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.1 1.4 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.1 4.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.6 GO:0002326 B cell lineage commitment(GO:0002326) ectopic germ cell programmed cell death(GO:0035234)
0.1 0.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.9 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.6 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.0 0.5 GO:0006527 arginine catabolic process(GO:0006527)
0.0 1.0 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 4.6 GO:0051028 mRNA transport(GO:0051028)
0.0 0.7 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 1.2 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.0 0.7 GO:0006301 postreplication repair(GO:0006301)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 2.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.2 GO:0032584 growth cone membrane(GO:0032584)
0.1 2.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.6 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.6 GO:0097433 dense body(GO:0097433)
0.1 0.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 7.5 GO:0055037 recycling endosome(GO:0055037)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 4.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.8 GO:0043204 perikaryon(GO:0043204)
0.0 7.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.3 1.3 GO:0097016 L27 domain binding(GO:0097016)
0.2 0.6 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.2 3.1 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.2 3.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.6 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 3.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.4 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 2.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.1 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 2.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 5.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.2 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.5 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.8 GO:0051219 phosphoprotein binding(GO:0051219)