Motif ID: Pbx1_Pbx3

Z-value: 1.389

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx1mm10_v2_chr1_-_168431896_168431905-0.682.3e-09Click!
Pbx3mm10_v2_chr2_-_34372004_343720440.563.4e-06Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_63711969 20.128 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr17_-_85688252 19.072 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chr14_-_48667508 15.593 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr19_+_55741810 15.030 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr4_-_3938354 14.976 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr17_+_85620816 14.195 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr19_+_55894508 13.576 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr17_-_70853482 12.895 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr13_+_15463837 12.368 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr12_+_72939724 11.035 ENSMUST00000021519.5
 Six6
sine oculis-related homeobox 6
chr11_-_19018956 10.435 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr4_-_43523388 10.245 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chr3_+_37639985 10.112 ENSMUST00000108107.1
 Spry1
sprouty homolog 1 (Drosophila)
chr3_+_37639945 9.543 ENSMUST00000108109.1
ENSMUST00000038569.1
 Spry1

sprouty homolog 1 (Drosophila)

chr4_+_3938888 9.494 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr19_-_9899450 9.241 ENSMUST00000025562.7
 Incenp
inner centromere protein
chrX_+_58030622 9.227 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr5_+_103425181 9.142 ENSMUST00000048957.9
 Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr17_+_47596061 9.016 ENSMUST00000182539.1
 Ccnd3
cyclin D3
chr17_+_85621017 8.868 ENSMUST00000162695.2
 Six3
sine oculis-related homeobox 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.5 43.9 GO:0048625 myoblast fate commitment(GO:0048625)
7.7 23.1 GO:0097402 neuroblast migration(GO:0097402)
6.7 20.1 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
3.9 19.7 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
4.8 19.1 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.8 18.9 GO:0035855 megakaryocyte development(GO:0035855)
3.9 15.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.9 15.0 GO:0060736 prostate gland growth(GO:0060736)
0.7 12.9 GO:0038092 nodal signaling pathway(GO:0038092)
4.1 12.4 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.2 11.2 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 9.5 GO:0006936 muscle contraction(GO:0006936)
1.5 9.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 9.2 GO:0000910 cytokinesis(GO:0000910)
0.1 9.1 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.5 9.0 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.7 8.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.8 8.3 GO:0060539 diaphragm development(GO:0060539)
0.8 7.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
2.5 7.4 GO:0006597 spermine biosynthetic process(GO:0006597)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 43.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 35.4 GO:0005667 transcription factor complex(GO:0005667)
3.0 26.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
4.0 20.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 13.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 12.4 GO:0016592 mediator complex(GO:0016592)
0.2 9.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
3.1 9.2 GO:0000801 central element(GO:0000801)
0.1 8.4 GO:0030496 midbody(GO:0030496)
0.3 7.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
1.4 6.8 GO:0008623 CHRAC(GO:0008623)
0.2 6.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 6.5 GO:0005769 early endosome(GO:0005769)
1.0 6.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 6.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.8 6.0 GO:0072687 meiotic spindle(GO:0072687)
0.1 5.8 GO:0000922 spindle pole(GO:0000922)
1.1 5.5 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.4 5.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 5.1 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 77.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.9 46.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.3 26.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.3 25.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 25.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 20.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
4.0 20.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.2 17.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 14.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.8 12.9 GO:0070410 co-SMAD binding(GO:0070410)
1.0 11.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 10.8 GO:0005178 integrin binding(GO:0005178)
0.2 9.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 9.0 GO:0035064 methylated histone binding(GO:0035064)
0.5 8.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 8.3 GO:0015197 peptide transporter activity(GO:0015197)
1.9 7.4 GO:0019808 polyamine binding(GO:0019808)
2.4 7.2 GO:0035939 microsatellite binding(GO:0035939)
2.3 6.8 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.3 6.6 GO:0032794 GTPase activating protein binding(GO:0032794)