Motif ID: Pbx2

Z-value: 0.642


Transcription factors associated with Pbx2:

Gene SymbolEntrez IDGene Name
Pbx2 ENSMUSG00000034673.8 Pbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx2mm10_v2_chr17_+_34592248_34592329-0.803.7e-14Click!


Activity profile for motif Pbx2.

activity profile for motif Pbx2


Sorted Z-values histogram for motif Pbx2

Sorted Z-values for motif Pbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 134 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_110095937 4.870 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
 Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr8_+_72646679 4.774 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr15_-_66812593 4.698 ENSMUST00000100572.3
 Sla
src-like adaptor
chr11_-_79504078 4.437 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr8_+_72646728 4.179 ENSMUST00000161254.1
 Nwd1
NACHT and WD repeat domain containing 1
chr6_+_8259288 4.065 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr11_+_3330781 3.926 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr3_-_152982240 3.895 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr11_+_3330401 3.758 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_+_128967383 3.452 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr2_-_104257400 3.033 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr6_+_8259327 2.991 ENSMUST00000159378.1
 Gm16039
predicted gene 16039
chr14_+_65969714 2.960 ENSMUST00000153460.1
 Clu
clusterin
chr15_+_92597104 2.834 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr6_+_8259379 2.731 ENSMUST00000162034.1
ENSMUST00000160705.1
ENSMUST00000159433.1
 Gm16039


predicted gene 16039


chr2_+_65620829 2.462 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr8_-_94696223 2.448 ENSMUST00000034227.4
 Pllp
plasma membrane proteolipid
chr18_-_31820413 2.301 ENSMUST00000165131.2
 Gm6665
predicted gene 6665
chr9_+_112234257 2.068 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr15_+_21111452 2.067 ENSMUST00000075132.6
 Cdh12
cadherin 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 7.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 4.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 4.2 GO:0006869 lipid transport(GO:0006869)
0.3 3.9 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 3.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.5 3.0 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.0 3.0 GO:0098792 xenophagy(GO:0098792)
0.6 2.5 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 2.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 2.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.8 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.3 1.7 GO:0030242 pexophagy(GO:0030242)
0.3 1.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.4 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 1.4 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.2 1.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 1.1 GO:0001553 luteinization(GO:0001553)
0.0 0.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 6.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 3.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.2 2.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 2.4 GO:0043218 compact myelin(GO:0043218)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0070847 core mediator complex(GO:0070847)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 7.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 6.7 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.6 3.9 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 3.7 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.3 3.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.0 GO:0051787 misfolded protein binding(GO:0051787)
0.2 2.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 1.8 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.8 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.4 1.7 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 1.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.2 1.4 GO:0017040 ceramidase activity(GO:0017040)
0.1 1.2 GO:0030553 cGMP binding(GO:0030553)
0.0 1.1 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.0 1.0 GO:0031489 myosin V binding(GO:0031489)
0.0 0.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.8 GO:0019905 syntaxin binding(GO:0019905)
0.1 0.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)