Motif ID: Pitx1

Z-value: 0.626


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 182 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_79164477 5.875 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr2_+_14388316 5.604 ENSMUST00000114731.1
ENSMUST00000082290.7
 Slc39a12

solute carrier family 39 (zinc transporter), member 12

chr4_-_64046925 5.524 ENSMUST00000107377.3
 Tnc
tenascin C
chr18_+_73863672 5.079 ENSMUST00000134847.1
 Mro
maestro
chr4_-_137766474 4.869 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr2_+_102658640 4.133 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr16_-_10313940 3.157 ENSMUST00000078357.4
 Emp2
epithelial membrane protein 2
chr14_+_27039001 3.094 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr1_+_74542881 3.051 ENSMUST00000113749.1
ENSMUST00000067916.6
ENSMUST00000113745.1
ENSMUST00000113747.1
ENSMUST00000113750.1
 Plcd4




phospholipase C, delta 4




chr8_-_46294592 2.998 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr17_-_58991343 2.672 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr6_-_93913678 2.591 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr2_+_91259822 2.340 ENSMUST00000138470.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr2_+_14388434 2.336 ENSMUST00000133258.1
 Slc39a12
solute carrier family 39 (zinc transporter), member 12
chr19_-_36919606 2.330 ENSMUST00000057337.7
 Fgfbp3
fibroblast growth factor binding protein 3
chr14_-_31640878 2.272 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
 Hacl1


2-hydroxyacyl-CoA lyase 1


chr1_-_170110491 2.128 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr14_+_26122609 2.122 ENSMUST00000100810.6
 Duxbl2
doubl homeobox B-like 2
chr11_+_82388900 2.084 ENSMUST00000054245.4
ENSMUST00000092852.2
 Tmem132e

transmembrane protein 132E

chr9_+_44101722 2.047 ENSMUST00000161703.1
ENSMUST00000161381.1
ENSMUST00000034654.7
 Mfrp


membrane-type frizzled-related protein



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 7.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.5 5.9 GO:0048484 enteric nervous system development(GO:0048484)
1.1 5.5 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.1 4.9 GO:0046677 response to antibiotic(GO:0046677)
0.7 4.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
1.3 3.8 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.3 3.2 GO:0003093 regulation of glomerular filtration(GO:0003093)
0.1 3.1 GO:0007340 acrosome reaction(GO:0007340)
0.1 3.1 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.2 3.0 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.3 2.8 GO:0042572 retinol metabolic process(GO:0042572)
0.5 2.3 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.3 2.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 2.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 2.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.3 2.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.7 2.0 GO:1904049 regulation of spontaneous neurotransmitter secretion(GO:1904048) negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.6 1.9 GO:0072554 blood vessel lumenization(GO:0072554)
0.1 1.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 1.8 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.3 5.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 5.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 5.2 GO:0031012 extracellular matrix(GO:0031012)
0.3 4.9 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 4.1 GO:0030673 axolemma(GO:0030673)
0.1 3.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.1 GO:0005652 nuclear lamina(GO:0005652)
0.4 2.0 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.4 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.4 1.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 1.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.9 5.5 GO:0045545 syndecan binding(GO:0045545)
0.1 5.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.2 4.9 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.0 4.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 3.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 3.8 GO:0030332 cyclin binding(GO:0030332)
0.0 3.2 GO:0005178 integrin binding(GO:0005178)
1.0 3.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 2.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.6 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 2.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.3 2.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.2 2.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 2.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 2.1 GO:0005112 Notch binding(GO:0005112)
0.1 2.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 1.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 1.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.8 GO:1990459 transferrin receptor binding(GO:1990459)