Motif ID: Pitx3

Z-value: 0.656


Transcription factors associated with Pitx3:

Gene SymbolEntrez IDGene Name
Pitx3 ENSMUSG00000025229.9 Pitx3



Activity profile for motif Pitx3.

activity profile for motif Pitx3


Sorted Z-values histogram for motif Pitx3

Sorted Z-values for motif Pitx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_7909542 3.365 ENSMUST00000086274.2
 Gm10490
predicted gene 10490
chr10_-_62899118 2.745 ENSMUST00000174189.1
 Tet1
tet methylcytosine dioxygenase 1
chr5_+_90759299 2.501 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr1_-_153408429 2.293 ENSMUST00000097535.4
 E330020D12Rik
Riken cDNA E330020D12 gene
chr7_-_75782080 2.261 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr11_-_79296906 2.074 ENSMUST00000068448.2
 Gm9964
predicted gene 9964
chr16_+_17276291 2.003 ENSMUST00000164950.1
ENSMUST00000159242.1
 Tmem191c

transmembrane protein 191C

chr9_+_118506226 1.879 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr17_-_71460395 1.843 ENSMUST00000180522.1
 Gm4707
predicted gene 4707
chrY_+_818646 1.795 ENSMUST00000115894.1
 Uba1y
ubiquitin-activating enzyme, Chr Y
chr2_+_28506095 1.781 ENSMUST00000074761.4
 Gm10134
predicted gene 10134
chr11_+_105146893 1.758 ENSMUST00000100338.1
 Gm10842
predicted gene 10842
chr4_-_116627921 1.681 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr14_-_20496780 1.669 ENSMUST00000022353.3
 Mss51
MSS51 mitochondrial translational activator
chr10_-_86011833 1.611 ENSMUST00000105304.1
ENSMUST00000061699.5
 Bpifc

BPI fold containing family C

chr3_-_36053512 1.596 ENSMUST00000166644.2
ENSMUST00000062056.8
 Ccdc144b

coiled-coil domain containing 144B

chr9_+_119357381 1.584 ENSMUST00000039610.8
 Xylb
xylulokinase homolog (H. influenzae)
chr4_-_86612009 1.570 ENSMUST00000125481.1
ENSMUST00000070607.7
 Haus6

HAUS augmin-like complex, subunit 6

chr1_+_85575676 1.557 ENSMUST00000178024.1
 G530012D18Rik
RIKEN cDNA G530012D1 gene
chr17_-_32189457 1.527 ENSMUST00000087721.3
ENSMUST00000162117.1
 Ephx3

epoxide hydrolase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0001824 blastocyst development(GO:0001824)
0.5 2.7 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.5 2.6 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.8 2.5 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.6 2.3 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.3 2.0 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.9 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.1 1.9 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 1.8 GO:0051225 spindle assembly(GO:0051225)
0.4 1.7 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 1.7 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 1.7 GO:0034724 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.1 1.7 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.3 1.5 GO:0036337 Fas signaling pathway(GO:0036337)
0.4 1.4 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.3 1.4 GO:0015705 iodide transport(GO:0015705)
0.3 1.4 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.3 1.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 1.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.3 GO:0000802 transverse filament(GO:0000802)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.1 1.7 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.6 GO:0070652 HAUS complex(GO:0070652)
0.1 1.5 GO:0042555 MCM complex(GO:0042555)
0.0 1.5 GO:0016607 nuclear speck(GO:0016607)
0.3 1.4 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 1.4 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.3 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.1 1.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.3 GO:0015030 Cajal body(GO:0015030)
0.1 1.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 1.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.2 GO:0071004 U2-type prespliceosome(GO:0071004)
0.2 1.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 1.0 GO:0031415 NatA complex(GO:0031415)
0.1 1.0 GO:0042575 DNA polymerase complex(GO:0042575)
0.3 0.9 GO:0031372 UBC13-MMS2 complex(GO:0031372)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.5 2.5 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.2 2.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.4 2.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.5 2.0 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 1.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.4 1.4 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 1.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.4 GO:0019707 protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 1.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 1.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.2 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.2 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.2 1.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 1.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.1 GO:0008139 nuclear localization sequence binding(GO:0008139)