Motif ID: Pknox2_Pknox1

Z-value: 0.946

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox1mm10_v2_chr17_+_31564749_315648540.676.7e-09Click!
Pknox2mm10_v2_chr9_-_37147257_371473230.066.8e-01Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 9.783 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr1_+_194619815 6.956 ENSMUST00000027952.5
 Plxna2
plexin A2
chr16_-_11176056 5.948 ENSMUST00000142389.1
ENSMUST00000138185.1
 Zc3h7a

zinc finger CCCH type containing 7 A

chr10_+_41810528 5.143 ENSMUST00000099931.3
 Sesn1
sestrin 1
chr5_-_109558957 4.797 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr5_-_134747241 4.593 ENSMUST00000015138.9
 Eln
elastin
chr2_-_34913976 4.475 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr2_-_113758638 4.379 ENSMUST00000099575.3
 Grem1
gremlin 1
chr5_-_138619653 4.302 ENSMUST00000129832.1
 Zfp68
zinc finger protein 68
chr7_-_131410495 4.197 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr18_+_49832622 4.046 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr5_-_138619751 3.893 ENSMUST00000085852.4
ENSMUST00000110905.2
 Zfp68

zinc finger protein 68

chr11_+_23256001 3.735 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
 Xpo1



exportin 1, CRM1 homolog (yeast)



chr12_-_24493656 3.711 ENSMUST00000073088.2
 Gm16372
predicted pseudogene 16372
chr7_-_131410325 3.409 ENSMUST00000154602.1
 Ikzf5
IKAROS family zinc finger 5
chr15_-_100599864 3.387 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr5_-_138619702 3.338 ENSMUST00000063262.4
 Zfp68
zinc finger protein 68
chr1_-_52727457 3.293 ENSMUST00000156876.1
ENSMUST00000087701.3
 Mfsd6

major facilitator superfamily domain containing 6

chr2_-_31141802 3.274 ENSMUST00000073879.5
ENSMUST00000100208.2
ENSMUST00000100207.2
ENSMUST00000113555.1
ENSMUST00000075326.4
ENSMUST00000113552.2
ENSMUST00000136181.1
 Fnbp1






formin binding protein 1






chr2_-_116065047 2.918 ENSMUST00000028639.6
ENSMUST00000102538.4
 Meis2

Meis homeobox 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 9.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.2 7.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.6 7.0 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 6.4 GO:0006897 endocytosis(GO:0006897)
0.1 5.4 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.4 5.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.8 4.8 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.0 4.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.6 4.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.5 4.4 GO:1901228 regulation of osteoclast proliferation(GO:0090289) negative regulation of bone mineralization involved in bone maturation(GO:1900158) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.6 3.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 3.4 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 2.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 2.9 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.4 2.5 GO:1905206 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0 2.5 GO:0002250 adaptive immune response(GO:0002250)
0.3 2.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 2.3 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 2.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.6 1.9 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.0 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 6.9 GO:0030424 axon(GO:0030424)
0.1 6.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 5.9 GO:0061700 GATOR2 complex(GO:0061700)
0.0 4.9 GO:0009897 external side of plasma membrane(GO:0009897)
1.5 4.6 GO:0071953 elastic fiber(GO:0071953)
0.2 4.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 4.2 GO:0009986 cell surface(GO:0009986)
0.4 3.7 GO:0005642 annulate lamellae(GO:0005642)
0.0 3.7 GO:0005938 cell cortex(GO:0005938)
0.2 2.3 GO:0043196 varicosity(GO:0043196)
0.0 2.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 1.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.4 GO:0031045 dense core granule(GO:0031045)
0.0 1.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.9 GO:0070695 FHF complex(GO:0070695)
0.1 0.9 GO:0098536 deuterosome(GO:0098536)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 9.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
1.8 7.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.5 7.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 6.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 5.4 GO:0020037 heme binding(GO:0020037)
0.0 5.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.9 5.1 GO:0070728 leucine binding(GO:0070728)
0.0 4.8 GO:0005125 cytokine activity(GO:0005125)
0.1 4.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 4.5 GO:0035064 methylated histone binding(GO:0035064)
0.5 4.4 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1 3.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 2.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.5 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 2.5 GO:0017022 myosin binding(GO:0017022)
0.6 2.3 GO:0008142 oxysterol binding(GO:0008142)
0.2 2.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 1.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)