Motif ID: Plag1

Z-value: 0.726


Transcription factors associated with Plag1:

Gene SymbolEntrez IDGene Name
Plag1 ENSMUSG00000003282.3 Plag1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plag1mm10_v2_chr4_-_3938354_3938401-0.708.8e-10Click!


Activity profile for motif Plag1.

activity profile for motif Plag1


Sorted Z-values histogram for motif Plag1

Sorted Z-values for motif Plag1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plag1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_133498538 7.829 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr4_-_129121699 5.969 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
 Hpca


hippocalcin


chr10_+_58813359 4.825 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr5_+_117841839 4.582 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr3_-_88000350 4.506 ENSMUST00000090971.5
 Bcan
brevican
chr11_+_77930800 4.145 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr4_-_129121889 4.028 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr19_-_5457397 3.841 ENSMUST00000179549.1
 Ccdc85b
coiled-coil domain containing 85B
chr7_-_27446599 3.653 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr7_-_79386943 3.591 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr16_-_18622403 3.585 ENSMUST00000167388.1
 Gp1bb
glycoprotein Ib, beta polypeptide
chr5_+_117781017 3.578 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr4_-_129121234 3.562 ENSMUST00000030572.3
 Hpca
hippocalcin
chr2_+_170731807 3.180 ENSMUST00000029075.4
 Dok5
docking protein 5
chr13_-_14523178 3.113 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr1_-_56969827 3.055 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr3_+_89520152 3.053 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr7_-_46099752 3.030 ENSMUST00000180081.1
 Kcnj11
potassium inwardly rectifying channel, subfamily J, member 11
chr19_-_59076069 2.966 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr11_+_74619594 2.958 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 318 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 13.6 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.2 12.3 GO:0021696 cerebellar cortex morphogenesis(GO:0021696)
0.4 10.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 8.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
2.0 8.2 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.5 8.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.1 7.7 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.9 5.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.1 5.4 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.2 4.9 GO:0010107 potassium ion import(GO:0010107)
0.2 4.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 4.4 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.4 4.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 4.1 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.8 4.0 GO:0061438 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439)
0.2 4.0 GO:0002021 response to dietary excess(GO:0002021)
1.3 3.8 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 3.8 GO:0033344 cholesterol efflux(GO:0033344)
0.1 3.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.5 3.6 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 14.7 GO:0044327 dendritic spine head(GO:0044327)
0.0 10.9 GO:0097060 synaptic membrane(GO:0097060)
0.2 9.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.5 7.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.6 6.8 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.1 6.7 GO:0008091 spectrin(GO:0008091)
0.0 6.5 GO:0044297 cell body(GO:0044297)
0.4 5.4 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.3 5.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 5.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 4.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 4.8 GO:0034704 calcium channel complex(GO:0034704)
0.0 4.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.8 GO:0005802 trans-Golgi network(GO:0005802)
0.2 4.7 GO:0097440 apical dendrite(GO:0097440)
0.3 4.3 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 4.2 GO:0031594 neuromuscular junction(GO:0031594)
0.2 3.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 3.8 GO:0032590 dendrite membrane(GO:0032590)
0.0 3.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 224 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 8.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.3 7.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.4 6.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 5.7 GO:0005509 calcium ion binding(GO:0005509)
0.1 5.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.6 5.4 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.7 5.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 5.0 GO:0030506 ankyrin binding(GO:0030506)
1.4 4.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 4.1 GO:0035497 cAMP response element binding(GO:0035497)
0.8 4.0 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.4 3.9 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 3.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.4 3.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 3.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 3.7 GO:0005267 potassium channel activity(GO:0005267)
0.9 3.6 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.4 3.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 3.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 3.5 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)