Motif ID: Ppard

Z-value: 0.474


Transcription factors associated with Ppard:

Gene SymbolEntrez IDGene Name
Ppard ENSMUSG00000002250.9 Ppard

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ppardmm10_v2_chr17_+_28232723_282327890.392.2e-03Click!


Activity profile for motif Ppard.

activity profile for motif Ppard


Sorted Z-values histogram for motif Ppard

Sorted Z-values for motif Ppard



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppard

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_87948666 5.738 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr10_-_13324160 2.380 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr4_+_118429701 2.141 ENSMUST00000067896.3
 Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr15_+_25773985 1.989 ENSMUST00000125667.1
 Myo10
myosin X
chr1_-_120120138 1.920 ENSMUST00000112648.1
ENSMUST00000128408.1
 Dbi

diazepam binding inhibitor

chr4_+_59581563 1.751 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr9_-_57262591 1.648 ENSMUST00000034846.5
 1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr4_+_59581645 1.631 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr5_-_115119277 1.570 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr9_-_51278540 1.523 ENSMUST00000114427.3
 Gm684
predicted gene 684
chr5_-_31697598 1.474 ENSMUST00000031018.7
 Rbks
ribokinase
chr3_+_98280427 1.456 ENSMUST00000090746.2
ENSMUST00000120541.1
 Hmgcs2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

chr17_-_34028044 1.435 ENSMUST00000045467.7
ENSMUST00000114303.3
 H2-Ke6

H2-K region expressed gene 6

chr5_+_110286306 1.434 ENSMUST00000007296.5
ENSMUST00000112482.1
 Pole

polymerase (DNA directed), epsilon

chr11_+_70657687 1.423 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr8_-_111393810 1.405 ENSMUST00000038475.8
 Fa2h
fatty acid 2-hydroxylase
chr3_-_79628660 1.376 ENSMUST00000120992.1
 Etfdh
electron transferring flavoprotein, dehydrogenase
chr18_+_74779190 1.338 ENSMUST00000041053.9
 Acaa2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
chr3_-_8923796 1.310 ENSMUST00000042148.5
 Mrps28
mitochondrial ribosomal protein S28
chr5_+_129725063 1.155 ENSMUST00000086046.3
 Gbas
glioblastoma amplified sequence
chr3_-_138131356 1.120 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr2_+_75832168 1.110 ENSMUST00000047232.7
ENSMUST00000111952.2
 Agps

alkylglycerone phosphate synthase

chr10_+_94147982 1.053 ENSMUST00000105290.2
 Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr5_-_110286159 1.042 ENSMUST00000031472.5
 Pxmp2
peroxisomal membrane protein 2
chr7_+_43444104 1.030 ENSMUST00000004729.3
 Etfb
electron transferring flavoprotein, beta polypeptide
chr11_-_4704334 1.016 ENSMUST00000058407.5
 Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr4_+_98546919 1.011 ENSMUST00000030290.7
 Inadl
InaD-like (Drosophila)
chr4_+_98546710 1.009 ENSMUST00000102792.3
 Inadl
InaD-like (Drosophila)
chrX_-_142306170 0.987 ENSMUST00000134825.2
 Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr6_+_7844806 0.951 ENSMUST00000040159.4
 C1galt1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr16_+_84835070 0.828 ENSMUST00000009120.7
 Gabpa
GA repeat binding protein, alpha
chr19_+_37207528 0.722 ENSMUST00000024078.7
ENSMUST00000112391.1
 March5

membrane-associated ring finger (C3HC4) 5

chr2_-_73911323 0.698 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr16_-_84835557 0.697 ENSMUST00000138279.1
ENSMUST00000023608.7
 Atp5j

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F

chr15_-_50890396 0.684 ENSMUST00000185183.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr3_-_79628859 0.681 ENSMUST00000029386.7
 Etfdh
electron transferring flavoprotein, dehydrogenase
chr9_-_22002599 0.666 ENSMUST00000115336.2
ENSMUST00000044926.5
 Ccdc151

coiled-coil domain containing 151

chr16_+_84834901 0.640 ENSMUST00000114184.1
 Gabpa
GA repeat binding protein, alpha
chr2_-_26237368 0.614 ENSMUST00000036187.8
 Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr15_-_89425856 0.594 ENSMUST00000109313.2
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr15_-_102189032 0.584 ENSMUST00000023805.1
 Csad
cysteine sulfinic acid decarboxylase
chr1_-_55088024 0.566 ENSMUST00000027123.8
 Hspd1
heat shock protein 1 (chaperonin)
chr4_-_45108038 0.548 ENSMUST00000107809.2
ENSMUST00000107808.2
ENSMUST00000107807.1
ENSMUST00000107810.2
 Tomm5



translocase of outer mitochondrial membrane 5 homolog (yeast)



chr19_-_32061438 0.541 ENSMUST00000096119.4
 Asah2
N-acylsphingosine amidohydrolase 2
chr13_-_86046901 0.475 ENSMUST00000131011.1
 Cox7c
cytochrome c oxidase subunit VIIc
chr11_-_70015346 0.465 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr1_+_74506044 0.458 ENSMUST00000087215.5
 Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr6_+_83156401 0.448 ENSMUST00000032106.4
 1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr4_+_118409331 0.439 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr10_+_128303322 0.433 ENSMUST00000005825.6
 Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr16_-_84835484 0.414 ENSMUST00000114191.1
 Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr3_+_90051630 0.389 ENSMUST00000159064.1
 4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr1_+_178319130 0.381 ENSMUST00000027781.6
 Cox20
COX20 Cox2 chaperone
chr7_+_82648595 0.353 ENSMUST00000141726.1
ENSMUST00000179489.1
ENSMUST00000039881.3
 Eftud1


elongation factor Tu GTP binding domain containing 1


chr11_+_98446826 0.335 ENSMUST00000019456.4
 Grb7
growth factor receptor bound protein 7
chr1_+_55088132 0.316 ENSMUST00000075242.6
 Hspe1
heat shock protein 1 (chaperonin 10)
chr12_-_40223149 0.312 ENSMUST00000171553.1
ENSMUST00000001672.5
 Ifrd1

interferon-related developmental regulator 1

chr10_-_93589621 0.259 ENSMUST00000020203.6
 Snrpf
small nuclear ribonucleoprotein polypeptide F
chr5_+_36464998 0.236 ENSMUST00000031099.3
 Grpel1
GrpE-like 1, mitochondrial
chr15_-_89425795 0.223 ENSMUST00000168376.1
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr4_-_41048124 0.193 ENSMUST00000030136.6
 Aqp7
aquaporin 7
chr5_+_31697665 0.180 ENSMUST00000080598.7
 Bre
brain and reproductive organ-expressed protein
chr6_+_85431970 0.167 ENSMUST00000045693.7
 Smyd5
SET and MYND domain containing 5
chr2_-_32704123 0.158 ENSMUST00000127812.1
 Fpgs
folylpolyglutamyl synthetase
chr5_+_31698050 0.148 ENSMUST00000114507.3
ENSMUST00000063813.4
ENSMUST00000071531.5
ENSMUST00000131995.1
 Bre



brain and reproductive organ-expressed protein



chr14_+_75136326 0.137 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1
chr19_+_4594312 0.125 ENSMUST00000113825.2
 Pcx
pyruvate carboxylase
chr5_+_31697960 0.121 ENSMUST00000114515.2
 Bre
brain and reproductive organ-expressed protein
chr1_+_171329376 0.106 ENSMUST00000111299.1
ENSMUST00000064950.4
 Dedd

death effector domain-containing

chr1_-_55088156 0.064 ENSMUST00000127861.1
ENSMUST00000144077.1
 Hspd1

heat shock protein 1 (chaperonin)

chr12_+_4082574 0.063 ENSMUST00000020986.7
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr4_-_137048695 0.014 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.4 5.7 GO:0042573 retinoic acid metabolic process(GO:0042573) positive regulation of collateral sprouting(GO:0048672)
0.4 1.2 GO:2000983 regulation of ATP citrate synthase activity(GO:2000983) negative regulation of ATP citrate synthase activity(GO:2000984)
0.4 1.9 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.2 1.0 GO:0099624 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) atrial cardiac muscle cell membrane repolarization(GO:0099624)
0.2 1.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.2 1.1 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 5.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.2 1.5 GO:0019321 pentose metabolic process(GO:0019321)
0.2 0.6 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.2 1.4 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 2.1 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 1.0 GO:0016266 O-glycan processing(GO:0016266)
0.2 1.4 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 1.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 1.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 1.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.7 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 1.5 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.1 1.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.7 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.2 GO:0015793 glycerol transport(GO:0015793)
0.0 0.4 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.7 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 2.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.4 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 0.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.3 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.5 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 1.4 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 0.8 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.4 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.6 GO:0045454 cell redox homeostasis(GO:0045454)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.3 1.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 1.8 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.6 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 1.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.4 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 1.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.0 GO:0016459 myosin complex(GO:0016459)
0.0 6.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 1.1 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.7 GO:0019841 retinol binding(GO:0019841)
0.7 2.1 GO:0048039 ubiquinone binding(GO:0048039)
0.5 1.9 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.2 1.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 1.4 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 1.0 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.2 2.1 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 0.8 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.2 1.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.6 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 4.8 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 2.0 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.1 1.0 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 0.5 GO:0017040 ceramidase activity(GO:0017040)
0.1 1.3 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.1 0.6 GO:0043559 insulin binding(GO:0043559)
0.1 1.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 2.0 GO:0030507 spectrin binding(GO:0030507)
0.0 1.5 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.2 GO:0015265 urea channel activity(GO:0015265)
0.0 1.5 GO:0009055 electron carrier activity(GO:0009055)
0.0 1.8 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.1 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)