Motif ID: Prox1

Z-value: 0.563


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.564.0e-06Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 86 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_60144682 3.119 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr1_-_169747634 2.856 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr17_-_70924958 2.450 ENSMUST00000180468.1
 Gm26510
predicted gene, 26510
chr17_-_34959232 2.103 ENSMUST00000165202.1
ENSMUST00000172753.1
 Hspa1b

heat shock protein 1B

chr18_-_20682963 1.950 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chr5_-_37824580 1.937 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr15_-_80014808 1.936 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr17_-_34972124 1.856 ENSMUST00000087328.2
ENSMUST00000179128.1
 Hspa1a

heat shock protein 1A

chr4_+_130913264 1.813 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr10_-_81025521 1.638 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_+_130913120 1.422 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr4_-_131821516 1.289 ENSMUST00000097860.2
 Ptpru
protein tyrosine phosphatase, receptor type, U
chr10_-_81025406 1.261 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_-_36951223 1.123 ENSMUST00000108122.1
 Lingo2
leucine rich repeat and Ig domain containing 2
chr7_-_19458494 1.120 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr19_+_41911851 1.083 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr17_+_27839974 1.076 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr11_+_4986824 0.978 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr2_-_92459709 0.971 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1

chr4_+_42950369 0.944 ENSMUST00000084662.5
 Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 2.1 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.6 1.9 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.6 1.9 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0 1.9 GO:0009408 response to heat(GO:0009408)
0.0 1.3 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 1.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.4 1.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 1.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 1.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 1.0 GO:0030259 lipid glycosylation(GO:0030259)
0.0 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 0.9 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.9 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.3 0.8 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.3 0.8 GO:0046618 drug export(GO:0046618)
0.4 0.7 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2 0.7 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 2.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 1.9 GO:0016234 inclusion body(GO:0016234)
0.1 1.1 GO:0000243 commitment complex(GO:0000243)
0.0 1.1 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.9 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.7 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.7 GO:0005921 gap junction(GO:0005921)
0.1 0.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.5 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.5 GO:0071565 nBAF complex(GO:0071565)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 1.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 1.9 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 1.9 GO:0002039 p53 binding(GO:0002039)
0.0 1.5 GO:0051087 chaperone binding(GO:0051087)
0.1 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.4 1.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 1.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 1.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.9 GO:0004601 peroxidase activity(GO:0004601)
0.2 0.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 0.7 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.7 GO:0016749 N-succinyltransferase activity(GO:0016749)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.4 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)