Motif ID: Prox1

Z-value: 0.563


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.564.0e-06Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_60144682 3.119 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr1_-_169747634 2.856 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr17_-_70924958 2.450 ENSMUST00000180468.1
 Gm26510
predicted gene, 26510
chr17_-_34959232 2.103 ENSMUST00000165202.1
ENSMUST00000172753.1
 Hspa1b

heat shock protein 1B

chr18_-_20682963 1.950 ENSMUST00000165229.2
 Gm10269
predicted gene 10269
chr5_-_37824580 1.937 ENSMUST00000063116.9
 Msx1
msh homeobox 1
chr15_-_80014808 1.936 ENSMUST00000000500.6
 Pdgfb
platelet derived growth factor, B polypeptide
chr17_-_34972124 1.856 ENSMUST00000087328.2
ENSMUST00000179128.1
 Hspa1a

heat shock protein 1A

chr4_+_130913264 1.813 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr10_-_81025521 1.638 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_+_130913120 1.422 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr4_-_131821516 1.289 ENSMUST00000097860.2
 Ptpru
protein tyrosine phosphatase, receptor type, U
chr10_-_81025406 1.261 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr4_-_36951223 1.123 ENSMUST00000108122.1
 Lingo2
leucine rich repeat and Ig domain containing 2
chr7_-_19458494 1.120 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr19_+_41911851 1.083 ENSMUST00000011896.6
 Pgam1
phosphoglycerate mutase 1
chr17_+_27839974 1.076 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr11_+_4986824 0.978 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr2_-_92459709 0.971 ENSMUST00000136718.1
ENSMUST00000067631.6
 Slc35c1

solute carrier family 35, member C1

chr4_+_42950369 0.944 ENSMUST00000084662.5
 Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr5_-_138187177 0.885 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
 Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr2_+_36230426 0.855 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chrX_-_43274786 0.853 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr4_+_140701466 0.794 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr6_+_58640536 0.781 ENSMUST00000145161.1
ENSMUST00000114294.1
 Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr19_+_46056539 0.741 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
 Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr9_-_106247730 0.714 ENSMUST00000112524.2
ENSMUST00000074082.6
 Alas1

aminolevulinic acid synthase 1

chr19_-_43524462 0.711 ENSMUST00000026196.7
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr6_-_131388417 0.704 ENSMUST00000032309.6
ENSMUST00000087865.2
 Ybx3

Y box protein 3

chr8_+_31111816 0.689 ENSMUST00000046941.7
 Rnf122
ring finger protein 122
chr7_-_127448993 0.677 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr8_-_85080679 0.636 ENSMUST00000093357.5
 Wdr83
WD repeat domain containing 83
chr17_-_83514311 0.616 ENSMUST00000167741.1
ENSMUST00000025095.7
 Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr14_-_96519067 0.593 ENSMUST00000022666.7
 Klhl1
kelch-like 1
chr2_+_27009926 0.547 ENSMUST00000114005.2
ENSMUST00000114004.1
ENSMUST00000114006.1
ENSMUST00000114007.1
 Cacfd1



calcium channel flower domain containing 1



chr12_-_83487708 0.524 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr7_-_127449109 0.523 ENSMUST00000053392.4
 Zfp689
zinc finger protein 689
chr7_-_126861648 0.504 ENSMUST00000129812.1
ENSMUST00000106342.1
 Ino80e

INO80 complex subunit E

chr19_+_46152505 0.493 ENSMUST00000026254.7
 Gbf1
golgi-specific brefeldin A-resistance factor 1
chr11_+_72207537 0.453 ENSMUST00000021158.3
 Txndc17
thioredoxin domain containing 17
chr14_-_55944536 0.450 ENSMUST00000022834.6
 Cma1
chymase 1, mast cell
chrX_-_73966329 0.444 ENSMUST00000114372.2
ENSMUST00000033761.6
 Hcfc1

host cell factor C1

chr15_-_89149557 0.439 ENSMUST00000088823.3
 Mapk11
mitogen-activated protein kinase 11
chr11_+_120784257 0.438 ENSMUST00000100134.3
 Gps1
G protein pathway suppressor 1
chr2_-_168734236 0.434 ENSMUST00000109175.2
 Atp9a
ATPase, class II, type 9A
chr11_-_115933464 0.427 ENSMUST00000021097.3
 Recql5
RecQ protein-like 5
chr5_+_139252343 0.423 ENSMUST00000130326.1
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr8_+_85080939 0.404 ENSMUST00000140621.1
 BC056474
cDNA sequence BC056474
chr8_-_85080652 0.382 ENSMUST00000152785.1
 Wdr83
WD repeat domain containing 83
chr2_-_26910569 0.382 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
 Med22


mediator complex subunit 22


chr8_+_99416585 0.371 ENSMUST00000064349.5
 A330008L17Rik
RIKEN cDNA A330008L17 gene
chr10_-_81496313 0.356 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr2_+_27009936 0.322 ENSMUST00000133807.1
 Cacfd1
calcium channel flower domain containing 1
chr11_-_120784183 0.322 ENSMUST00000026156.7
 Rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_-_64726583 0.318 ENSMUST00000168366.1
 Rab11a
RAB11a, member RAS oncogene family
chr7_+_24081888 0.316 ENSMUST00000068975.3
 Zfp180
zinc finger protein 180
chr10_-_81496329 0.316 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr12_-_36042476 0.313 ENSMUST00000020896.8
 Tspan13
tetraspanin 13
chr2_+_34406882 0.311 ENSMUST00000113123.1
 Mapkap1
mitogen-activated protein kinase associated protein 1
chr2_+_34406949 0.305 ENSMUST00000040459.4
 Mapkap1
mitogen-activated protein kinase associated protein 1
chr7_+_127777095 0.289 ENSMUST00000144406.1
 Setd1a
SET domain containing 1A
chr7_-_80947499 0.280 ENSMUST00000120285.1
 Sec11a
SEC11 homolog A (S. cerevisiae)
chr2_+_34406845 0.277 ENSMUST00000124443.1
ENSMUST00000113124.1
 Mapkap1

mitogen-activated protein kinase associated protein 1

chr9_-_110117303 0.211 ENSMUST00000136969.1
 Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr5_+_139211934 0.210 ENSMUST00000148772.1
ENSMUST00000110882.1
 Sun1

Sad1 and UNC84 domain containing 1

chr8_-_70476911 0.206 ENSMUST00000066597.5
ENSMUST00000166976.1
 Klhl26

kelch-like 26

chr7_+_28716846 0.196 ENSMUST00000108279.2
 Fbxo17
F-box protein 17
chr11_+_19924354 0.193 ENSMUST00000093299.6
 Spred2
sprouty-related, EVH1 domain containing 2
chr9_+_104569671 0.184 ENSMUST00000057742.8
 Cpne4
copine IV
chr5_+_124112297 0.179 ENSMUST00000024470.6
ENSMUST00000119269.1
 Ogfod2

2-oxoglutarate and iron-dependent oxygenase domain containing 2

chr8_-_99416397 0.178 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
 Cdh8




cadherin 8




chr17_+_47630690 0.174 ENSMUST00000024779.8
 Usp49
ubiquitin specific peptidase 49
chr2_+_136891501 0.174 ENSMUST00000141463.1
 Slx4ip
SLX4 interacting protein
chr4_-_133967235 0.173 ENSMUST00000123234.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr17_+_37045963 0.150 ENSMUST00000025338.9
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr5_+_139252314 0.147 ENSMUST00000026976.5
 Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr7_+_28716777 0.146 ENSMUST00000032818.6
ENSMUST00000108278.2
 Fbxo17

F-box protein 17

chr11_+_19924403 0.139 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr19_-_15924560 0.106 ENSMUST00000162053.1
 Psat1
phosphoserine aminotransferase 1
chr12_+_40222758 0.102 ENSMUST00000038121.4
 Gm7008
predicted gene 7008
chr2_-_136891131 0.096 ENSMUST00000144275.1
 Mkks
McKusick-Kaufman syndrome
chr4_+_59003121 0.080 ENSMUST00000095070.3
ENSMUST00000174664.1
 Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr2_-_167062981 0.066 ENSMUST00000048988.7
 Znfx1
zinc finger, NFX1-type containing 1
chr6_+_146796041 0.062 ENSMUST00000111639.1
 Arntl2
aryl hydrocarbon receptor nuclear translocator-like 2
chr12_-_40223149 0.027 ENSMUST00000171553.1
ENSMUST00000001672.5
 Ifrd1

interferon-related developmental regulator 1

chr14_-_59440779 0.002 ENSMUST00000111253.2
ENSMUST00000095775.3
ENSMUST00000161459.1
 Setdb2


SET domain, bifurcated 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.6 1.9 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.4 1.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.4 0.7 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.3 0.9 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.3 0.8 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.3 0.8 GO:0046618 drug export(GO:0046618)
0.2 0.7 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.2 1.0 GO:0030259 lipid glycosylation(GO:0030259)
0.2 0.5 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 1.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.4 GO:0019042 viral latency(GO:0019042)
0.1 0.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 2.1 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.1 0.4 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 0.4 GO:0072610 interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.1 0.6 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 2.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.2 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.2 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.6 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 1.9 GO:0009408 response to heat(GO:0009408)
0.0 0.7 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 1.3 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.9 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 1.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.6 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 1.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 1.1 GO:0000243 commitment complex(GO:0000243)
0.1 0.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.9 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.7 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.5 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.7 GO:0005921 gap junction(GO:0005921)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.9 GO:0016234 inclusion body(GO:0016234)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.5 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 3.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.0 GO:1902636 kinociliary basal body(GO:1902636)
0.0 1.1 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.4 1.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 0.7 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2 1.9 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 0.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 1.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 2.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 1.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.4 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.3 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.7 GO:0016749 N-succinyltransferase activity(GO:0016749)
0.0 0.9 GO:0004601 peroxidase activity(GO:0004601)
0.0 1.5 GO:0051087 chaperone binding(GO:0051087)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)