Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.547

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrxl1mm10_v2_chr14_+_32599922_32599932-0.571.9e-06Click!
Prrx1mm10_v2_chr1_-_163289214_1632892350.211.2e-01Click!


Activity profile for motif Prrx1_Isx_Prrxl1.

activity profile for motif Prrx1_Isx_Prrxl1


Sorted Z-values histogram for motif Prrx1_Isx_Prrxl1

Sorted Z-values for motif Prrx1_Isx_Prrxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_27556613 2.096 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr2_-_67194695 2.093 ENSMUST00000147939.1
 Gm13598
predicted gene 13598
chr17_+_27556668 2.077 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr3_+_146121655 1.980 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr9_+_118478344 1.967 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr17_+_27556641 1.885 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr12_+_79297345 1.828 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr11_+_94936224 1.787 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr3_-_59220150 1.688 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr9_+_35423582 1.539 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr9_+_118478182 1.536 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr8_-_106573461 1.440 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr4_+_5724304 1.421 ENSMUST00000108380.1
 Fam110b
family with sequence similarity 110, member B
chr4_-_58499398 1.335 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr4_-_134767940 1.247 ENSMUST00000037828.6
 Ldlrap1
low density lipoprotein receptor adaptor protein 1
chr14_-_118052235 1.200 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr12_-_73047179 1.184 ENSMUST00000050029.7
 Six1
sine oculis-related homeobox 1
chr5_+_15516489 1.060 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr1_-_152625212 1.024 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr15_+_81744848 1.012 ENSMUST00000109554.1
 Zc3h7b
zinc finger CCCH type containing 7B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 GO:0006284 base-excision repair(GO:0006284)
1.2 3.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.5 1.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.3 1.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.6 1.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 1.7 GO:0032439 endosome localization(GO:0032439)
0.2 1.5 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.3 1.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 1.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.4 1.2 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.2 1.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 1.2 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.4 1.1 GO:0006566 threonine metabolic process(GO:0006566)
0.0 1.1 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.1 1.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 1.0 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 1.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 0.9 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278) regulation of vascular wound healing(GO:0061043) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.1 0.9 GO:0019532 oxalate transport(GO:0019532)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 3.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 1.8 GO:0005584 collagen type I trimer(GO:0005584)
0.4 1.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 1.7 GO:0045179 apical cortex(GO:0045179)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.3 1.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 1.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 1.0 GO:0031983 vesicle lumen(GO:0031983)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.9 GO:0034709 methylosome(GO:0034709)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.7 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.2 0.6 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.6 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 6.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 3.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.8 GO:0000150 recombinase activity(GO:0000150)
0.1 1.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 1.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.0 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.9 GO:0031369 translation initiation factor binding(GO:0031369)
0.3 0.8 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 0.8 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)