Motif ID: Ptf1a

Z-value: 0.502


Transcription factors associated with Ptf1a:

Gene SymbolEntrez IDGene Name
Ptf1a ENSMUSG00000026735.2 Ptf1a



Activity profile for motif Ptf1a.

activity profile for motif Ptf1a


Sorted Z-values histogram for motif Ptf1a

Sorted Z-values for motif Ptf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Ptf1a

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_64046925 4.318 ENSMUST00000107377.3
 Tnc
tenascin C
chr7_-_79386943 3.924 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr11_+_78324200 3.127 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr16_+_91269759 3.018 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr15_+_31276491 1.598 ENSMUST00000068987.5
 Fam136b-ps
family with sequence similarity 136, member B, pseudogene
chr19_+_7056731 1.302 ENSMUST00000040261.5
 Macrod1
MACRO domain containing 1
chr2_+_26973416 1.136 ENSMUST00000014996.7
ENSMUST00000102891.3
 Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

chr1_-_16770138 1.118 ENSMUST00000071842.8
 Gm5828
predicted gene 5828
chr10_+_90829538 0.905 ENSMUST00000179694.2
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chrX_+_166238923 0.902 ENSMUST00000060210.7
ENSMUST00000112233.1
 Gpm6b

glycoprotein m6b

chr5_+_64970069 0.831 ENSMUST00000031080.8
 Fam114a1
family with sequence similarity 114, member A1
chr11_-_90390895 0.827 ENSMUST00000004051.7
 Hlf
hepatic leukemia factor
chr9_-_112187766 0.781 ENSMUST00000111872.2
ENSMUST00000164754.2
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_112187898 0.760 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr11_-_109611417 0.746 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
 Wipi1


WD repeat domain, phosphoinositide interacting 1


chr17_+_7925990 0.723 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr5_-_99252839 0.710 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr4_-_88438900 0.696 ENSMUST00000132493.1
ENSMUST00000030221.2
ENSMUST00000151280.1
 Ptplad2


protein tyrosine phosphatase-like A domain containing 2


chr11_-_6444352 0.674 ENSMUST00000093346.5
ENSMUST00000109737.2
 H2afv

H2A histone family, member V

chr2_-_7395968 0.636 ENSMUST00000002176.6
 Celf2
CUGBP, Elav-like family member 2
chr9_-_112234956 0.631 ENSMUST00000162097.1
ENSMUST00000159055.1
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr14_-_70207637 0.626 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr2_-_91950386 0.618 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chrX_+_101383726 0.521 ENSMUST00000119190.1
 Gjb1
gap junction protein, beta 1
chr2_+_31470207 0.518 ENSMUST00000102840.4
 Ass1
argininosuccinate synthetase 1
chr1_+_92910805 0.515 ENSMUST00000179711.1
 Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr10_-_95417099 0.508 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr15_+_80097866 0.506 ENSMUST00000143928.1
 Syngr1
synaptogyrin 1
chr10_+_86022189 0.489 ENSMUST00000120344.1
ENSMUST00000117597.1
 Fbxo7

F-box protein 7

chr2_+_164948219 0.480 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr9_+_123021315 0.441 ENSMUST00000084733.5
 Tmem42
transmembrane protein 42
chr7_-_144582392 0.436 ENSMUST00000033394.7
 Fadd
Fas (TNFRSF6)-associated via death domain
chr11_-_96916448 0.428 ENSMUST00000103152.4
 Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr4_+_152096719 0.406 ENSMUST00000105661.3
ENSMUST00000084115.3
 Plekhg5

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

chr11_-_96916407 0.398 ENSMUST00000130774.1
 Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr1_+_92910758 0.386 ENSMUST00000027487.8
 Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr7_-_140102367 0.356 ENSMUST00000142105.1
 Fuom
fucose mutarotase
chr7_+_46396439 0.350 ENSMUST00000025202.6
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr19_+_9982694 0.330 ENSMUST00000025563.6
 Fth1
ferritin heavy chain 1
chr9_+_106477269 0.327 ENSMUST00000047721.8
 Rrp9
RRP9, small subunit (SSU) processome component, homolog (yeast)
chr11_-_118355496 0.326 ENSMUST00000017610.3
 Timp2
tissue inhibitor of metalloproteinase 2
chr16_+_43762221 0.324 ENSMUST00000023390.4
 Drd3
dopamine receptor D3
chr11_-_100441006 0.306 ENSMUST00000092689.2
 Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr11_-_100441058 0.291 ENSMUST00000107399.2
ENSMUST00000092688.5
 Nt5c3b

5'-nucleotidase, cytosolic IIIB

chr2_+_25500750 0.284 ENSMUST00000015239.3
 Fbxw5
F-box and WD-40 domain protein 5
chr11_-_100440928 0.283 ENSMUST00000107397.1
 Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr8_-_13890233 0.271 ENSMUST00000033839.7
 Coprs
coordinator of PRMT5, differentiation stimulator
chr4_+_155839675 0.265 ENSMUST00000141883.1
 Mxra8
matrix-remodelling associated 8
chr11_-_96916366 0.263 ENSMUST00000144731.1
ENSMUST00000127048.1
 Cdk5rap3

CDK5 regulatory subunit associated protein 3

chr9_-_108305941 0.257 ENSMUST00000044725.7
 Tcta
T cell leukemia translocation altered gene
chr3_-_75556759 0.250 ENSMUST00000162138.1
ENSMUST00000029424.5
ENSMUST00000161137.1
 Pdcd10


programmed cell death 10


chr2_-_30415302 0.247 ENSMUST00000132981.2
ENSMUST00000129494.1
 Crat

carnitine acetyltransferase

chr18_+_34331132 0.240 ENSMUST00000072576.3
ENSMUST00000119329.1
 Srp19

signal recognition particle 19

chr8_+_94857450 0.227 ENSMUST00000109521.3
 Polr2c
polymerase (RNA) II (DNA directed) polypeptide C
chr18_+_24709436 0.225 ENSMUST00000037097.7
 Fhod3
formin homology 2 domain containing 3
chr4_-_155010984 0.224 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr19_+_16435616 0.212 ENSMUST00000025602.2
 Gna14
guanine nucleotide binding protein, alpha 14
chr10_+_127501707 0.206 ENSMUST00000035839.2
 Stac3
SH3 and cysteine rich domain 3
chr10_+_127501672 0.194 ENSMUST00000160019.1
ENSMUST00000160610.1
 Stac3

SH3 and cysteine rich domain 3

chr11_+_49247462 0.191 ENSMUST00000109194.1
 Mgat1
mannoside acetylglucosaminyltransferase 1
chr11_+_78465697 0.181 ENSMUST00000001126.3
 Slc46a1
solute carrier family 46, member 1
chr14_+_75845093 0.172 ENSMUST00000110894.2
 Tpt1
tumor protein, translationally-controlled 1
chr7_-_79842287 0.171 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr1_+_36691487 0.167 ENSMUST00000081180.4
 Cox5b
cytochrome c oxidase subunit Vb
chr10_+_42678890 0.162 ENSMUST00000040718.5
 Ostm1
osteopetrosis associated transmembrane protein 1
chr11_+_86484647 0.138 ENSMUST00000020827.6
 Rnft1
ring finger protein, transmembrane 1
chr2_-_131175201 0.132 ENSMUST00000110218.2
 Spef1
sperm flagellar 1
chr9_-_108597558 0.125 ENSMUST00000006853.5
 P4htm
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr5_+_134099704 0.119 ENSMUST00000016088.8
 Gatsl2
GATS protein-like 2
chr15_-_79774383 0.114 ENSMUST00000069877.5
 Dnal4
dynein, axonemal, light chain 4
chrX_-_164076482 0.104 ENSMUST00000134272.1
 Siah1b
seven in absentia 1B
chr7_-_127725616 0.094 ENSMUST00000076091.2
 Ctf2
cardiotrophin 2
chr1_+_20951666 0.090 ENSMUST00000038447.4
 Efhc1
EF-hand domain (C-terminal) containing 1
chr16_-_55283237 0.088 ENSMUST00000036412.3
 Zpld1
zona pellucida like domain containing 1
chr11_+_120633719 0.081 ENSMUST00000181502.1
 Gm17586
predicted gene, 17586
chr7_-_99182681 0.080 ENSMUST00000033001.4
 Dgat2
diacylglycerol O-acyltransferase 2
chr11_-_102185202 0.075 ENSMUST00000107156.2
 Lsm12
LSM12 homolog (S. cerevisiae)
chr11_-_103344651 0.072 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr11_+_48800357 0.071 ENSMUST00000020640.7
 Gnb2l1
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
chr11_+_40733936 0.071 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chr11_+_98446826 0.062 ENSMUST00000019456.4
 Grb7
growth factor receptor bound protein 7
chr2_+_71981184 0.062 ENSMUST00000090826.5
ENSMUST00000102698.3
 Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

chr15_-_79774408 0.061 ENSMUST00000023055.6
 Dnal4
dynein, axonemal, light chain 4
chr18_+_32377176 0.060 ENSMUST00000091967.5
ENSMUST00000025239.7
 Bin1

bridging integrator 1

chr6_+_83078606 0.049 ENSMUST00000177177.1
ENSMUST00000176089.1
 Pcgf1

polycomb group ring finger 1

chr1_-_88008520 0.040 ENSMUST00000040783.4
 Usp40
ubiquitin specific peptidase 40
chr14_-_55944536 0.024 ENSMUST00000022834.6
 Cma1
chymase 1, mast cell
chr10_-_126901315 0.016 ENSMUST00000026504.5
ENSMUST00000168520.1
 Xrcc6bp1

XRCC6 binding protein 1

chr11_+_82911253 0.015 ENSMUST00000164945.1
ENSMUST00000018989.7
 Unc45b

unc-45 homolog B (C. elegans)

chr2_+_164769892 0.012 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr10_+_60346851 0.009 ENSMUST00000020301.7
ENSMUST00000105460.1
ENSMUST00000170507.1
 4632428N05Rik


RIKEN cDNA 4632428N05 gene


chr2_-_175131864 0.003 ENSMUST00000108929.2
 Gm14399
predicted gene 14399
chr6_+_83078339 0.000 ENSMUST00000165164.2
ENSMUST00000092614.2
 Pcgf1

polycomb group ring finger 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.3 1.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.3 3.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.4 GO:2000409 positive regulation of T cell extravasation(GO:2000409)
0.1 0.5 GO:0010046 arginine biosynthetic process(GO:0006526) response to mycotoxin(GO:0010046)
0.1 0.9 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 1.1 GO:0071569 protein ufmylation(GO:0071569)
0.1 0.3 GO:0060160 musculoskeletal movement, spinal reflex action(GO:0050883) negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.1 0.5 GO:0031915 positive regulation of synaptic plasticity(GO:0031915) positive regulation of receptor binding(GO:1900122)
0.1 2.2 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.9 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.7 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.1 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.3 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 0.5 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 0.3 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 2.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.2 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.2 GO:0015886 heme transport(GO:0015886)
0.0 0.4 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.2 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 0.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 3.0 GO:0048663 neuron fate commitment(GO:0048663)
0.0 2.7 GO:0007601 visual perception(GO:0007601)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.5 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.3 GO:0097286 iron ion import(GO:0097286)
0.0 0.4 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.1 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.0 0.6 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.5 GO:0070852 cell body fiber(GO:0070852)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.2 GO:0045298 tubulin complex(GO:0045298)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.4 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.3 GO:0045545 syndecan binding(GO:0045545)
0.7 3.9 GO:0019841 retinol binding(GO:0019841)
0.5 3.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0035877 death effector domain binding(GO:0035877) caspase binding(GO:0089720)
0.1 0.3 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588) dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.3 GO:0070636 single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.1 0.4 GO:0042806 fucose binding(GO:0042806)
0.1 0.6 GO:0001727 lipid kinase activity(GO:0001727)
0.1 0.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.3 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 1.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 0.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.2 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.5 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)