Motif ID: Rela_Rel_Nfkb1

Z-value: 1.369

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb1mm10_v2_chr3_-_135691512_1356915640.889.6e-20Click!
Relamm10_v2_chr19_+_5637475_5637486-0.038.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103843154 18.880 ENSMUST00000063957.4
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr2_-_165234689 18.471 ENSMUST00000065438.6
Cdh22
cadherin 22
chr6_+_4755327 13.008 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr7_-_25788635 12.093 ENSMUST00000002677.4
ENSMUST00000085948.4
Axl

AXL receptor tyrosine kinase

chr14_-_70642268 10.729 ENSMUST00000022697.5
Fgf17
fibroblast growth factor 17
chr18_+_4994600 9.255 ENSMUST00000140448.1
Svil
supervillin
chr12_+_79029150 9.064 ENSMUST00000039928.5
Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr1_+_74791516 8.629 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr8_-_61902669 8.498 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr15_-_79164477 8.132 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chr19_+_46304709 8.097 ENSMUST00000073116.5
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr2_+_10153563 6.970 ENSMUST00000026886.7
Itih5
inter-alpha (globulin) inhibitor H5
chr2_-_156839790 6.704 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
Gm14230


predicted gene 14230


chr6_+_48841476 6.351 ENSMUST00000101426.4
Tmem176a
transmembrane protein 176A
chr19_-_58455161 6.123 ENSMUST00000135730.1
ENSMUST00000152507.1
Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1

chr3_-_135691512 6.102 ENSMUST00000029812.7
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr3_+_14641722 6.031 ENSMUST00000029071.8
Car13
carbonic anhydrase 13
chr13_+_112464070 5.913 ENSMUST00000183663.1
ENSMUST00000184311.1
ENSMUST00000183886.1
Il6st


interleukin 6 signal transducer


chr6_+_48841633 5.792 ENSMUST00000168406.1
Tmem176a
transmembrane protein 176A
chr19_-_58454580 5.791 ENSMUST00000129100.1
ENSMUST00000123957.1
Gfra1

glial cell line derived neurotrophic factor family receptor alpha 1


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 18.9 GO:0015671 oxygen transport(GO:0015671)
2.1 14.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.7 13.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 13.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
1.2 12.5 GO:0008063 Toll signaling pathway(GO:0008063)
2.0 12.1 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.9 10.3 GO:0048484 enteric nervous system development(GO:0048484)
0.1 9.4 GO:0044344 cellular response to fibroblast growth factor stimulus(GO:0044344)
0.8 9.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 9.3 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.6 8.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 8.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.4 7.0 GO:0002467 germinal center formation(GO:0002467)
0.3 7.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
1.1 6.9 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
2.3 6.8 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.9 6.6 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
1.3 6.4 GO:0046601 positive regulation of centriole replication(GO:0046601)
1.5 6.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.2 6.2 GO:0006730 one-carbon metabolic process(GO:0006730)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 20.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
2.4 18.9 GO:0005833 hemoglobin complex(GO:0005833)
0.2 18.7 GO:0031225 anchored component of membrane(GO:0031225)
0.6 13.0 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.3 12.2 GO:0043034 costamere(GO:0043034)
0.7 10.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 9.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 9.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.1 8.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.6 8.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 8.3 GO:0002102 podosome(GO:0002102)
0.1 8.0 GO:0000922 spindle pole(GO:0000922)
0.0 8.0 GO:0043209 myelin sheath(GO:0043209)
0.6 6.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
2.2 6.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 6.5 GO:0005882 intermediate filament(GO:0005882)
0.8 6.4 GO:0098536 deuterosome(GO:0098536)
1.3 5.3 GO:0043020 NADPH oxidase complex(GO:0043020)
1.0 5.1 GO:0031523 Myb complex(GO:0031523)
0.0 4.7 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 35.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.2 22.3 GO:0005178 integrin binding(GO:0005178)
4.7 18.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 17.2 GO:0051015 actin filament binding(GO:0051015)
0.0 13.6 GO:0044822 poly(A) RNA binding(GO:0044822)
1.0 12.5 GO:0031996 thioesterase binding(GO:0031996)
1.2 12.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 11.1 GO:0005109 frizzled binding(GO:0005109)
3.6 10.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 9.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 9.0 GO:0005509 calcium ion binding(GO:0005509)
0.1 8.8 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 8.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 8.3 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 7.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 7.4 GO:0042805 actinin binding(GO:0042805)
0.2 7.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 6.5 GO:0019215 intermediate filament binding(GO:0019215)
0.5 6.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
2.0 5.9 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)