Motif ID: Rest

Z-value: 4.575


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_77266232-0.706.7e-10Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23890805 140.213 ENSMUST00000004480.3
 Sst
somatostatin
chrX_-_73869804 133.383 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr19_+_42255704 116.707 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr18_-_31447383 88.715 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr15_-_76521902 83.526 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr2_+_153031852 76.310 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr11_-_35798884 75.397 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr11_+_80477015 67.459 ENSMUST00000053413.10
ENSMUST00000147694.1
 Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr6_-_121473630 66.394 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr11_+_77930800 61.825 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr1_+_34579693 61.383 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr9_+_40269430 59.616 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr3_-_80802789 55.929 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr9_+_40269202 53.704 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr2_+_155775333 52.710 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr9_+_40269273 50.719 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr4_-_129121234 49.317 ENSMUST00000030572.3
 Hpca
hippocalcin
chr12_-_112511136 49.136 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr7_-_81493725 47.831 ENSMUST00000119121.1
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr12_+_102554966 47.726 ENSMUST00000021610.5
 Chga
chromogranin A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
18.2 164.0 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.2 140.2 GO:0030334 regulation of cell migration(GO:0030334)
33.5 133.8 GO:0021586 pons maturation(GO:0021586)
13.3 133.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
11.2 101.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
4.6 92.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.9 83.5 GO:2001222 regulation of neuron migration(GO:2001222)
15.1 75.4 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
2.7 66.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
2.9 61.8 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
2.4 56.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.9 55.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 53.1 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
4.8 52.7 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
16.4 49.3 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
15.9 47.7 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
0.7 47.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
15.5 46.5 GO:0060084 conditioned taste aversion(GO:0001661) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
1.4 44.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
7.4 44.2 GO:0072318 clathrin coat disassembly(GO:0072318)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 209.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 179.4 GO:0005794 Golgi apparatus(GO:0005794)
0.3 169.7 GO:0043025 neuronal cell body(GO:0043025)
10.3 164.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 148.0 GO:0016021 integral component of membrane(GO:0016021)
0.1 142.7 GO:0005886 plasma membrane(GO:0005886)
2.6 136.4 GO:0044295 axonal growth cone(GO:0044295)
8.4 92.6 GO:1904115 axon cytoplasm(GO:1904115)
5.9 88.7 GO:0031045 dense core granule(GO:0031045)
2.2 85.4 GO:0097440 apical dendrite(GO:0097440)
0.0 83.8 GO:0005634 nucleus(GO:0005634)
9.4 75.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
2.2 69.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
22.5 67.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
16.6 66.4 GO:0044307 dendritic branch(GO:0044307)
2.3 66.4 GO:0060077 inhibitory synapse(GO:0060077)
1.4 56.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
4.9 49.3 GO:0044327 dendritic spine head(GO:0044327)
0.3 49.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
9.5 47.7 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 468.0 GO:0003674 molecular_function(GO:0003674)
3.0 171.0 GO:0005179 hormone activity(GO:0005179)
23.4 164.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
26.7 133.4 GO:0033691 sialic acid binding(GO:0033691)
0.2 89.7 GO:0005509 calcium ion binding(GO:0005509)
2.9 85.4 GO:0001786 phosphatidylserine binding(GO:0001786)
1.2 75.4 GO:0042054 histone methyltransferase activity(GO:0042054)
2.9 67.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
6.0 66.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.8 66.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.2 61.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
1.4 56.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 56.0 GO:0051219 phosphoprotein binding(GO:0051219)
9.3 55.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
2.5 54.1 GO:0017075 syntaxin-1 binding(GO:0017075)
1.1 52.7 GO:0045296 cadherin binding(GO:0045296)
1.8 47.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 47.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
4.2 46.5 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
4.5 44.7 GO:0042301 phosphate ion binding(GO:0042301)