Motif ID: Rfx3_Rfx1_Rfx4

Z-value: 2.240

Transcription factors associated with Rfx3_Rfx1_Rfx4:

Gene SymbolEntrez IDGene Name
Rfx1 ENSMUSG00000031706.6 Rfx1
Rfx3 ENSMUSG00000040929.10 Rfx3
Rfx4 ENSMUSG00000020037.9 Rfx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx4mm10_v2_chr10_+_84838143_84838153-0.401.8e-03Click!
Rfx1mm10_v2_chr8_+_84066824_840668820.374.2e-03Click!
Rfx3mm10_v2_chr19_-_28011138_28011181-0.066.6e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_7919816 37.605 ENSMUST00000041096.3
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr11_-_6606053 17.396 ENSMUST00000045713.3
Nacad
NAC alpha domain containing
chr10_-_81472859 17.122 ENSMUST00000147524.1
ENSMUST00000119060.1
Celf5

CUGBP, Elav-like family member 5

chr10_+_80295930 12.560 ENSMUST00000105359.1
Apc2
adenomatosis polyposis coli 2
chr15_+_98167806 12.230 ENSMUST00000031914.4
AI836003
expressed sequence AI836003
chr7_+_99268338 11.898 ENSMUST00000107100.2
Map6
microtubule-associated protein 6
chr18_-_78206408 11.500 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr7_-_140082246 11.429 ENSMUST00000166758.2
Caly
calcyon neuron-specific vesicular protein
chr7_-_4546567 11.283 ENSMUST00000065957.5
Syt5
synaptotagmin V
chr12_+_29528382 11.034 ENSMUST00000049784.9
Myt1l
myelin transcription factor 1-like
chr7_-_140082489 10.700 ENSMUST00000026541.7
Caly
calcyon neuron-specific vesicular protein
chr19_-_46327121 10.448 ENSMUST00000041391.4
ENSMUST00000096029.5
Psd

pleckstrin and Sec7 domain containing

chr9_+_59589288 9.955 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6

CUGBP, Elav-like family member 6

chr5_+_30814571 9.329 ENSMUST00000031058.8
Mapre3
microtubule-associated protein, RP/EB family, member 3
chr13_+_55464237 9.267 ENSMUST00000046533.7
Prr7
proline rich 7 (synaptic)
chr5_+_30814722 9.178 ENSMUST00000114724.1
Mapre3
microtubule-associated protein, RP/EB family, member 3
chr5_+_33983437 8.884 ENSMUST00000114384.1
ENSMUST00000094869.5
ENSMUST00000114383.1
Gm1673


predicted gene 1673


chr3_-_84305385 8.798 ENSMUST00000122849.1
ENSMUST00000132283.1
Trim2

tripartite motif-containing 2

chr10_+_106470281 8.564 ENSMUST00000029404.9
ENSMUST00000169303.1
Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr11_-_61453992 8.535 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
Rnf112


ring finger protein 112



Gene overrepresentation in biological_process category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 37.6 GO:0016486 response to dietary excess(GO:0002021) peptide hormone processing(GO:0016486)
1.0 21.9 GO:0048268 clathrin coat assembly(GO:0048268)
1.0 19.3 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
4.6 18.5 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.7 18.4 GO:0060074 synapse maturation(GO:0060074)
0.2 17.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 16.0 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
3.2 15.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
1.1 14.7 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.5 13.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.6 12.9 GO:0071625 vocalization behavior(GO:0071625)
0.3 11.9 GO:0032418 lysosome localization(GO:0032418)
1.6 11.5 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
2.0 9.8 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
2.9 8.8 GO:0010751 regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.2 8.8 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
1.4 8.5 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.9 7.7 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
1.3 7.5 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.7 7.5 GO:0051823 regulation of synapse structural plasticity(GO:0051823)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 87.8 GO:0016021 integral component of membrane(GO:0016021)
0.2 46.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 26.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.7 22.9 GO:0035371 microtubule plus-end(GO:0035371)
1.8 19.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 19.0 GO:0005769 early endosome(GO:0005769)
0.2 16.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.8 15.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 13.7 GO:0016607 nuclear speck(GO:0016607)
0.5 13.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 12.6 GO:0005794 Golgi apparatus(GO:0005794)
0.8 11.3 GO:0031045 dense core granule(GO:0031045)
0.1 9.9 GO:0031225 anchored component of membrane(GO:0031225)
0.3 9.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.4 7.7 GO:0097228 sperm principal piece(GO:0097228)
0.8 7.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.5 6.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 6.8 GO:0031430 M band(GO:0031430)
0.0 6.1 GO:0097060 synaptic membrane(GO:0097060)
0.1 5.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 38.7 GO:0008270 zinc ion binding(GO:0008270)
0.8 38.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 33.3 GO:0008017 microtubule binding(GO:0008017)
3.7 22.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.8 19.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 15.6 GO:0030276 clathrin binding(GO:0030276)
0.4 13.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.9 11.5 GO:0015265 urea channel activity(GO:0015265)
0.7 11.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.7 10.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
1.3 10.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.7 10.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.4 9.8 GO:0032183 SUMO binding(GO:0032183)
0.1 9.0 GO:0017137 Rab GTPase binding(GO:0017137)
1.0 8.1 GO:0001618 virus receptor activity(GO:0001618)
0.3 8.0 GO:0045296 cadherin binding(GO:0045296)
0.9 7.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 7.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 7.0 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.2 6.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)