Motif ID: Rfx5

Z-value: 0.761


Transcription factors associated with Rfx5:

Gene SymbolEntrez IDGene Name
Rfx5 ENSMUSG00000005774.6 Rfx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_94954226-0.357.1e-03Click!


Activity profile for motif Rfx5.

activity profile for motif Rfx5


Sorted Z-values histogram for motif Rfx5

Sorted Z-values for motif Rfx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_34263209 6.218 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr7_+_46841475 5.292 ENSMUST00000147535.1
 Ldha
lactate dehydrogenase A
chr7_-_30664986 5.158 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr17_+_35861318 4.419 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr17_+_35861343 4.058 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr1_-_183147461 3.946 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr2_+_122147680 3.893 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr17_+_37270214 3.866 ENSMUST00000038580.6
 H2-M3
histocompatibility 2, M region locus 3
chr17_+_35439155 3.761 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr7_-_105752193 3.697 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr8_+_94214567 3.304 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr11_+_61505138 2.578 ENSMUST00000102657.3
 B9d1
B9 protein domain 1
chr17_+_35379608 2.552 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr7_+_100537192 2.452 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr4_-_35845204 2.365 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr11_+_98682554 2.269 ENSMUST00000017365.8
 Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr7_+_100537052 2.238 ENSMUST00000054310.3
 Coa4
cytochrome c oxidase assembly factor 4
chr12_+_108334341 2.072 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr4_-_116627921 2.063 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr17_-_34187219 2.045 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr11_-_3539228 2.040 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
 Smtn



smoothelin



chr7_-_45092130 1.993 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr17_-_24886304 1.988 ENSMUST00000044252.5
 Nubp2
nucleotide binding protein 2
chr2_-_152398046 1.952 ENSMUST00000063332.8
ENSMUST00000182625.1
 Sox12

SRY-box containing gene 12

chr17_+_34305883 1.878 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr5_+_139150211 1.827 ENSMUST00000026975.6
 Heatr2
HEAT repeat containing 2
chr19_+_37376359 1.674 ENSMUST00000012587.3
 Kif11
kinesin family member 11
chr13_+_24831661 1.654 ENSMUST00000038039.2
 Tdp2
tyrosyl-DNA phosphodiesterase 2
chr8_-_69996326 1.571 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr5_-_36830647 1.534 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr7_-_45091713 1.499 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr10_-_19011948 1.465 ENSMUST00000105527.1
 Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr11_+_72441341 1.461 ENSMUST00000045633.5
 Mybbp1a
MYB binding protein (P160) 1a
chr18_-_51865881 1.352 ENSMUST00000091905.2
 Gm4950
predicted pseudogene 4950
chr3_-_95882031 1.304 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr17_+_34398802 1.274 ENSMUST00000114175.1
ENSMUST00000078615.5
ENSMUST00000139063.1
ENSMUST00000097348.2
 BC051142



cDNA sequence BC051142



chr2_-_128687354 1.248 ENSMUST00000110332.1
ENSMUST00000110333.1
ENSMUST00000014499.3
 Anapc1


anaphase promoting complex subunit 1


chr10_-_7663245 1.240 ENSMUST00000163085.1
ENSMUST00000159917.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr8_+_84969587 1.196 ENSMUST00000109734.1
ENSMUST00000005292.8
 Prdx2

peroxiredoxin 2

chr5_-_125294107 1.112 ENSMUST00000127148.1
 Scarb1
scavenger receptor class B, member 1
chr3_-_95882193 1.086 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chrX_-_160138375 0.987 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr6_-_29165003 0.938 ENSMUST00000007993.9
 Rbm28
RNA binding motif protein 28
chr1_+_134405984 0.891 ENSMUST00000173908.1
 Cyb5r1
cytochrome b5 reductase 1
chr9_+_44773191 0.788 ENSMUST00000147559.1
 Ift46
intraflagellar transport 46
chr17_+_34187789 0.753 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr18_+_60803838 0.683 ENSMUST00000050487.8
ENSMUST00000097563.2
ENSMUST00000167610.1
 Cd74


CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)


chr17_+_34187545 0.647 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr10_-_7663569 0.636 ENSMUST00000162606.1
 Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr10_-_123196916 0.613 ENSMUST00000020334.7
 Usp15
ubiquitin specific peptidase 15
chr7_-_101921186 0.577 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr11_+_117523526 0.575 ENSMUST00000132261.1
 Gm11734
predicted gene 11734
chr7_-_101921175 0.555 ENSMUST00000098236.2
 Lrrc51
leucine rich repeat containing 51
chr19_-_10482874 0.545 ENSMUST00000038842.3
 Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr19_-_4615647 0.536 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr1_+_136676413 0.524 ENSMUST00000181491.1
 Gm19705
predicted gene, 19705
chr14_+_111675113 0.311 ENSMUST00000042767.7
 Slitrk5
SLIT and NTRK-like family, member 5
chr8_+_27042555 0.249 ENSMUST00000033875.8
ENSMUST00000098851.4
 Prosc

proline synthetase co-transcribed

chr8_-_89187560 0.240 ENSMUST00000093326.2
 Gm5356
predicted pseudogene 5356
chr3_-_95882232 0.205 ENSMUST00000161866.1
 Gm129
predicted gene 129
chr19_+_32757497 0.202 ENSMUST00000013807.7
 Pten
phosphatase and tensin homolog
chr17_+_24886643 0.158 ENSMUST00000117890.1
ENSMUST00000168265.1
ENSMUST00000120943.1
ENSMUST00000068508.6
ENSMUST00000119829.1
 Spsb3




splA/ryanodine receptor domain and SOCS box containing 3




chr6_-_8259098 0.125 ENSMUST00000012627.4
 Rpa3
replication protein A3
chr19_-_8819314 0.057 ENSMUST00000096751.4
 Ttc9c
tetratricopeptide repeat domain 9C
chr9_-_51102062 0.043 ENSMUST00000170947.1
 4833427G06Rik
RIKEN cDNA 4833427G06 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.2 GO:0002339 B cell selection(GO:0002339)
1.3 3.9 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
1.1 5.3 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.8 3.9 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.5 1.5 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.4 4.7 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.4 1.6 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.4 1.1 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.4 3.9 GO:0060539 diaphragm development(GO:0060539)
0.3 1.4 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.3 1.7 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.3 2.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 1.5 GO:2000210 positive regulation of anoikis(GO:2000210)
0.2 3.3 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 0.2 GO:1901630 negative regulation of presynaptic membrane organization(GO:1901630)
0.2 1.5 GO:0006013 mannose metabolic process(GO:0006013)
0.2 0.7 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.2 0.6 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.2 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 1.0 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 3.7 GO:0043171 peptide catabolic process(GO:0043171)
0.1 3.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 2.1 GO:0043486 histone exchange(GO:0043486)
0.1 2.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 1.9 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.1 5.2 GO:0051225 spindle assembly(GO:0051225)
0.0 1.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 2.6 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 2.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.9 GO:0034341 response to interferon-gamma(GO:0034341)
0.0 2.0 GO:0021510 spinal cord development(GO:0021510)
0.0 0.9 GO:0016126 sterol biosynthetic process(GO:0016126)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.8 11.4 GO:0042611 MHC protein complex(GO:0042611)
0.6 5.2 GO:0070652 HAUS complex(GO:0070652)
0.5 8.5 GO:0005652 nuclear lamina(GO:0005652)
0.5 1.5 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.4 5.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 1.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 2.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 1.4 GO:0042825 TAP complex(GO:0042825)
0.2 2.6 GO:0036038 MKS complex(GO:0036038)
0.1 1.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 2.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 4.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 3.3 GO:0005643 nuclear pore(GO:0005643)
0.0 1.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.7 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 6.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 2.1 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.9 3.7 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.9 2.6 GO:0008158 hedgehog receptor activity(GO:0008158)
0.7 6.2 GO:0015643 toxic substance binding(GO:0015643)
0.5 7.7 GO:0046977 TAP binding(GO:0046977)
0.4 3.9 GO:0015197 peptide transporter activity(GO:0015197)
0.4 1.9 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.4 1.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 0.7 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 1.0 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.2 3.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.0 GO:0070628 proteasome binding(GO:0070628)
0.1 1.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.2 GO:0042605 peptide antigen binding(GO:0042605)
0.1 2.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.5 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.1 1.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 2.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 2.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 2.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 1.7 GO:0030145 manganese ion binding(GO:0030145)
0.0 3.9 GO:0001948 glycoprotein binding(GO:0001948)
0.0 0.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.6 GO:0030674 protein binding, bridging(GO:0030674)