Motif ID: Rhox4e_Rhox6_Vax2

Z-value: 1.261

Transcription factors associated with Rhox4e_Rhox6_Vax2:

Gene SymbolEntrez IDGene Name
Rhox4e ENSMUSG00000071770.4 Rhox4e
Rhox6 ENSMUSG00000006200.3 Rhox6
Vax2 ENSMUSG00000034777.1 Vax2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vax2mm10_v2_chr6_+_83711232_83711288-0.123.5e-01Click!


Activity profile for motif Rhox4e_Rhox6_Vax2.

activity profile for motif Rhox4e_Rhox6_Vax2


Sorted Z-values histogram for motif Rhox4e_Rhox6_Vax2

Sorted Z-values for motif Rhox4e_Rhox6_Vax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 20.798 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_25005895 8.486 ENSMUST00000102858.3
ENSMUST00000080882.6
 Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr8_+_45658731 8.122 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr8_+_45658666 8.062 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr4_+_15881255 7.726 ENSMUST00000029876.1
 Calb1
calbindin 1
chr4_-_129227883 6.679 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chrX_+_150547375 6.081 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr1_-_89933290 5.515 ENSMUST00000036954.7
 Gbx2
gastrulation brain homeobox 2
chr13_-_102906046 5.514 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_55782500 5.507 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr2_-_168767136 5.358 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr13_-_102905740 5.169 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr9_+_53771499 5.135 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr14_+_4871156 4.845 ENSMUST00000166410.2
 Gm3264
predicted gene 3264
chr14_-_6741430 4.625 ENSMUST00000100904.4
 Gm3636
predicted gene 3636
chr2_-_168767029 4.408 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr14_-_6411578 4.405 ENSMUST00000179312.1
 Gm3591
predicted gene 3591
chr5_+_37185897 4.397 ENSMUST00000094840.3
 Gm1043
predicted gene 1043
chr14_+_5517172 4.379 ENSMUST00000178220.1
 Gm3488
predicted gene, 3488
chr14_+_5164535 4.379 ENSMUST00000179659.1
 Gm3317
predicted gene 3317

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 20.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 19.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 11.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.5 9.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.7 8.5 GO:0036376 sodium ion export from cell(GO:0036376)
0.1 8.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 7.7 GO:0007614 short-term memory(GO:0007614)
0.5 6.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 6.1 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.8 5.5 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.2 4.1 GO:0007530 sex determination(GO:0007530)
0.1 4.1 GO:0035329 hippo signaling(GO:0035329)
0.0 4.1 GO:0043010 camera-type eye development(GO:0043010)
0.4 3.7 GO:0016198 axon choice point recognition(GO:0016198)
0.1 3.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.8 3.1 GO:0061738 late endosomal microautophagy(GO:0061738)
0.1 3.1 GO:0022904 respiratory electron transport chain(GO:0022904)
1.0 3.0 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
1.0 2.9 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.4 2.9 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 9.8 GO:0000792 heterochromatin(GO:0000792)
1.2 8.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) dendritic spine neck(GO:0044326)
0.1 7.7 GO:0043195 terminal bouton(GO:0043195)
0.4 6.2 GO:0042555 MCM complex(GO:0042555)
0.0 5.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 4.3 GO:0005874 microtubule(GO:0005874)
0.4 4.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.2 3.7 GO:0031527 filopodium membrane(GO:0031527)
1.0 2.9 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.7 2.9 GO:0060187 cell pole(GO:0060187)
0.4 2.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 2.7 GO:0005581 collagen trimer(GO:0005581)
0.0 2.6 GO:0043025 neuronal cell body(GO:0043025)
0.1 2.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 2.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 2.2 GO:0033503 HULC complex(GO:0033503)
0.0 2.2 GO:0070469 respiratory chain(GO:0070469)
0.3 2.1 GO:0090543 Flemming body(GO:0090543)
0.2 2.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 19.7 GO:0019904 protein domain specific binding(GO:0019904)
0.0 10.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 9.8 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
1.1 8.5 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 8.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 7.7 GO:0019842 vitamin binding(GO:0019842)
0.1 7.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 6.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.4 6.1 GO:0016594 glycine binding(GO:0016594)
0.2 5.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.6 3.7 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 3.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.0 GO:0004601 peroxidase activity(GO:0004601)
0.4 2.9 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.4 2.7 GO:0034056 estrogen response element binding(GO:0034056)
0.1 2.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 2.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.6 1.7 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)