Motif ID: Runx2_Bcl11a

Z-value: 1.198

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24078173_24078219-0.142.8e-01Click!


Activity profile for motif Runx2_Bcl11a.

activity profile for motif Runx2_Bcl11a


Sorted Z-values histogram for motif Runx2_Bcl11a

Sorted Z-values for motif Runx2_Bcl11a



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 18.759 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr11_-_83649349 7.680 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr4_+_144892813 6.800 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr19_+_3935186 5.917 ENSMUST00000162708.1
ENSMUST00000165711.1
 Unc93b1

unc-93 homolog B1 (C. elegans)

chr1_+_58210397 5.485 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr15_-_66801577 5.334 ENSMUST00000168589.1
 Sla
src-like adaptor
chr4_-_136892867 5.238 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr1_-_140183404 4.926 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr9_-_103219823 4.850 ENSMUST00000168142.1
 Trf
transferrin
chr3_-_87263518 4.780 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr4_+_144893127 4.168 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_61171954 4.126 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr8_-_11008458 4.002 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr5_+_90772435 3.769 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr3_-_90514250 3.761 ENSMUST00000107340.1
ENSMUST00000060738.8
 S100a1

S100 calcium binding protein A1

chr15_-_37459327 3.668 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr11_+_101246960 3.512 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr13_-_37050237 3.498 ENSMUST00000164727.1
 F13a1
coagulation factor XIII, A1 subunit
chr3_-_88000350 3.485 ENSMUST00000090971.5
 Bcan
brevican
chr3_-_87263703 3.453 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 280 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 14.0 GO:0042572 retinol metabolic process(GO:0042572)
1.0 9.1 GO:0043615 astrocyte cell migration(GO:0043615)
1.3 7.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.0 7.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
2.0 5.9 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
1.8 5.5 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
1.8 5.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.8 5.4 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 5.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.7 5.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.6 4.8 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
0.5 4.3 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.4 4.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 3.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.8 3.8 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.4 3.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 3.5 GO:0018149 peptide cross-linking(GO:0018149)
0.5 3.2 GO:0001887 selenium compound metabolic process(GO:0001887)
1.0 3.1 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
1.0 3.0 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 36.0 GO:0005615 extracellular space(GO:0005615)
4.7 18.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 17.0 GO:0072562 blood microparticle(GO:0072562)
0.0 10.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 8.2 GO:0019866 organelle inner membrane(GO:0019866)
1.0 7.8 GO:0032009 early phagosome(GO:0032009)
0.0 5.6 GO:0043235 receptor complex(GO:0043235)
0.6 4.8 GO:0097433 dense body(GO:0097433)
0.4 4.4 GO:0031091 platelet alpha granule(GO:0031091)
0.0 4.4 GO:0031012 extracellular matrix(GO:0031012)
0.2 4.0 GO:0031430 M band(GO:0031430)
0.0 3.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.5 3.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 3.4 GO:0097225 sperm midpiece(GO:0097225)
0.1 3.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 3.4 GO:0005769 early endosome(GO:0005769)
0.1 3.1 GO:0031594 neuromuscular junction(GO:0031594)
1.0 3.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.7 2.9 GO:0001533 cornified envelope(GO:0001533)
0.6 2.8 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 18.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
2.0 13.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.5 10.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
2.5 7.6 GO:0001851 complement component C3b binding(GO:0001851)
0.3 7.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.7 5.7 GO:0035325 Toll-like receptor binding(GO:0035325)
1.9 5.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.4 5.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.3 5.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 5.3 GO:0050811 GABA receptor binding(GO:0050811)
0.1 5.1 GO:0008083 growth factor activity(GO:0008083)
0.7 4.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 4.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 4.2 GO:0043014 alpha-tubulin binding(GO:0043014)
1.0 3.9 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
1.3 3.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.4 3.8 GO:0044548 S100 protein binding(GO:0044548)
0.0 3.8 GO:0017124 SH3 domain binding(GO:0017124)
0.6 3.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.9 3.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)