Motif ID: Runx3

Z-value: 0.605


Transcription factors associated with Runx3:

Gene SymbolEntrez IDGene Name
Runx3 ENSMUSG00000070691.4 Runx3



Activity profile for motif Runx3.

activity profile for motif Runx3


Sorted Z-values histogram for motif Runx3

Sorted Z-values for motif Runx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_20181773 5.239 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr3_-_154330543 3.209 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr13_-_22041352 3.121 ENSMUST00000102977.2
 Hist1h4i
histone cluster 1, H4i
chr13_-_23551648 2.149 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr7_+_141216626 1.895 ENSMUST00000141804.1
ENSMUST00000148975.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr13_-_23698454 1.730 ENSMUST00000102967.1
 Hist1h4c
histone cluster 1, H4c
chr17_+_27556668 1.709 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr17_+_27556641 1.697 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr17_+_27556613 1.697 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr15_+_40655020 1.660 ENSMUST00000053467.4
 Zfpm2
zinc finger protein, multitype 2
chr11_-_89302545 1.602 ENSMUST00000061728.3
 Nog
noggin
chr13_-_21832194 1.600 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chrX_+_99136119 1.548 ENSMUST00000052839.6
 Efnb1
ephrin B1
chr18_-_47368446 1.521 ENSMUST00000076043.6
ENSMUST00000135790.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr7_-_78783026 1.467 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr18_-_77713978 1.402 ENSMUST00000074653.4
 8030462N17Rik
RIKEN cDNA 8030462N17 gene
chr13_+_21735055 1.340 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr13_+_51645232 1.250 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr11_-_5878207 1.211 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr6_-_100671126 1.180 ENSMUST00000089245.6
ENSMUST00000113312.2
ENSMUST00000170667.1
 Shq1


SHQ1 homolog (S. cerevisiae)


chr2_-_71546745 1.081 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr14_-_72709534 1.046 ENSMUST00000162478.1
 Fndc3a
fibronectin type III domain containing 3A
chr13_+_37826225 0.910 ENSMUST00000128570.1
 Rreb1
ras responsive element binding protein 1
chr10_-_62602261 0.908 ENSMUST00000045866.7
 Ddx21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr14_-_72709986 0.900 ENSMUST00000089017.5
 Fndc3a
fibronectin type III domain containing 3A
chr13_-_35906324 0.893 ENSMUST00000174230.1
ENSMUST00000171686.2
 Rpp40

ribonuclease P 40 subunit

chr17_+_30005029 0.888 ENSMUST00000057897.7
 Zfand3
zinc finger, AN1-type domain 3
chr10_+_128083273 0.876 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr7_+_28808795 0.871 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr11_+_75679259 0.827 ENSMUST00000017920.7
ENSMUST00000108426.1
ENSMUST00000108425.1
ENSMUST00000093115.3
 Crk



v-crk sarcoma virus CT10 oncogene homolog (avian)



chr2_+_72476159 0.825 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr2_+_72476225 0.815 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr4_-_120570252 0.813 ENSMUST00000030381.7
 Ctps
cytidine 5'-triphosphate synthase
chr9_-_108094459 0.769 ENSMUST00000081309.7
 Apeh
acylpeptide hydrolase
chr9_-_20898592 0.721 ENSMUST00000004206.8
 Eif3g
eukaryotic translation initiation factor 3, subunit G
chr9_-_78481724 0.703 ENSMUST00000042235.8
 Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr4_-_116627478 0.685 ENSMUST00000081182.4
ENSMUST00000030457.5
 Nasp

nuclear autoantigenic sperm protein (histone-binding)

chr7_+_78783119 0.682 ENSMUST00000032840.4
 Mrps11
mitochondrial ribosomal protein S11
chr5_+_45493374 0.671 ENSMUST00000046122.6
 Lap3
leucine aminopeptidase 3
chr9_+_106429537 0.611 ENSMUST00000059802.6
 Rpl29
ribosomal protein L29
chr13_-_115101909 0.602 ENSMUST00000061673.7
 Itga1
integrin alpha 1
chr9_+_106429399 0.584 ENSMUST00000150576.1
 Rpl29
ribosomal protein L29
chr13_-_25020289 0.556 ENSMUST00000021772.2
 Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr7_-_35802968 0.544 ENSMUST00000061586.4
 Zfp507
zinc finger protein 507
chr2_+_155517948 0.505 ENSMUST00000029135.8
ENSMUST00000065973.2
ENSMUST00000103142.5
 Acss2


acyl-CoA synthetase short-chain family member 2


chr7_-_16816731 0.469 ENSMUST00000061390.7
 Fkrp
fukutin related protein
chr17_+_28328471 0.468 ENSMUST00000042334.8
 Rpl10a
ribosomal protein L10A
chr17_+_8165501 0.464 ENSMUST00000097419.3
ENSMUST00000024636.8
 Fgfr1op

Fgfr1 oncogene partner

chr8_+_4243264 0.459 ENSMUST00000110996.1
 Map2k7
mitogen-activated protein kinase kinase 7
chr13_-_14063395 0.448 ENSMUST00000170957.1
 Ggps1
geranylgeranyl diphosphate synthase 1
chr5_-_36830647 0.419 ENSMUST00000031002.3
 Man2b2
mannosidase 2, alpha B2
chr11_-_84916338 0.397 ENSMUST00000103195.4
 Znhit3
zinc finger, HIT type 3
chr2_+_145785980 0.389 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2

chr2_-_50296680 0.370 ENSMUST00000144143.1
ENSMUST00000102769.4
ENSMUST00000133768.1
 Mmadhc


methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria


chr9_+_70012540 0.369 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
 Gtf2a2




general transcription factor II A, 2




chr6_-_99632376 0.353 ENSMUST00000176255.1
 Gm20696
predicted gene 20696
chr8_+_71908595 0.352 ENSMUST00000131544.1
ENSMUST00000110002.1
ENSMUST00000125802.1
 Zfp617
Zfp882

zinc finger protein 617
zinc finger protein 882

chr3_+_122245625 0.346 ENSMUST00000178826.1
 Gclm
glutamate-cysteine ligase, modifier subunit
chr17_+_35879770 0.344 ENSMUST00000025292.8
 Dhx16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr16_+_92301266 0.328 ENSMUST00000063641.4
ENSMUST00000118064.1
 Smim11

small integral membrane protein 11

chr18_-_3337539 0.310 ENSMUST00000142690.1
ENSMUST00000025069.4
ENSMUST00000082141.5
ENSMUST00000165086.1
ENSMUST00000149803.1
 Crem




cAMP responsive element modulator




chr7_+_35802593 0.305 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr1_-_24100306 0.292 ENSMUST00000027337.8
 Fam135a
family with sequence similarity 135, member A
chr11_-_23665862 0.265 ENSMUST00000020523.3
 Pex13
peroxisomal biogenesis factor 13
chrX_-_73458990 0.238 ENSMUST00000033737.8
ENSMUST00000077243.4
 Haus7

HAUS augmin-like complex, subunit 7

chr11_-_70220969 0.208 ENSMUST00000060010.2
 Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr3_+_95658771 0.205 ENSMUST00000178686.1
 Mcl1
myeloid cell leukemia sequence 1
chr5_-_25223153 0.163 ENSMUST00000066954.1
 E130116L18Rik
RIKEN cDNA E130116L18 gene
chr3_+_95658714 0.158 ENSMUST00000037947.8
 Mcl1
myeloid cell leukemia sequence 1
chr7_+_3617357 0.129 ENSMUST00000076657.4
ENSMUST00000108644.1
 Ndufa3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3

chr9_+_121719403 0.124 ENSMUST00000182225.1
 Nktr
natural killer tumor recognition sequence
chr1_+_58713241 0.116 ENSMUST00000114309.1
ENSMUST00000069333.7
 Cflar

CASP8 and FADD-like apoptosis regulator

chr11_-_70410010 0.100 ENSMUST00000019065.3
ENSMUST00000135148.1
 Pelp1

proline, glutamic acid and leucine rich protein 1

chr5_+_121397936 0.082 ENSMUST00000042163.8
 Naa25
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
chr18_-_34651703 0.046 ENSMUST00000025228.5
ENSMUST00000133181.1
 Cdc23

CDC23 cell division cycle 23

chr13_+_14063776 0.029 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
 Arid4b




AT rich interactive domain 4B (RBP1-like)




chr11_-_5762358 0.013 ENSMUST00000120306.1
ENSMUST00000170116.1
ENSMUST00000053427.4
ENSMUST00000118076.1
 Urgcp



upregulator of cell proliferation



chr11_-_70220794 0.011 ENSMUST00000159867.1
 Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0003195 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.5 9.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.5 4.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 1.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.4 1.2 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.4 1.1 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.2 0.9 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 0.5 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.7 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.9 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.1 0.9 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.1 5.1 GO:0006284 base-excision repair(GO:0006284)
0.1 0.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 2.0 GO:0060009 Sertoli cell development(GO:0060009)
0.1 1.5 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.1 0.8 GO:0046036 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.1 1.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 3.2 GO:0021884 forebrain neuron development(GO:0021884)
0.1 0.1 GO:0014891 striated muscle atrophy(GO:0014891)
0.1 0.3 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.8 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.7 GO:0034724 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.5 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.6 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.9 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.7 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.3 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.5 GO:0034453 microtubule anchoring(GO:0034453)
0.0 1.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.8 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.3 GO:0007127 meiosis I(GO:0007127)
0.0 0.4 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 1.2 GO:0006261 DNA-dependent DNA replication(GO:0006261)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.5 3.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 1.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.9 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.1 9.2 GO:0000786 nucleosome(GO:0000786)
0.1 0.9 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 1.2 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.3 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 0.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.4 4.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 0.8 GO:0003883 CTP synthase activity(GO:0003883)
0.2 0.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 0.6 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.4 GO:0048045 4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.1 0.9 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.5 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.5 GO:0043842 Kdo transferase activity(GO:0043842)
0.1 0.3 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.9 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 1.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 2.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 9.8 GO:0042393 histone binding(GO:0042393)
0.0 0.8 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.5 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.6 GO:0019955 cytokine binding(GO:0019955)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.4 GO:0044653 trehalase activity(GO:0015927) dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 2.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)