Motif ID: Six3_Six1_Six2

Z-value: 0.662

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six1mm10_v2_chr12_-_73047179_730471790.522.8e-05Click!
Six2mm10_v2_chr17_-_85688252_856882750.504.8e-05Click!
Six3mm10_v2_chr17_+_85620816_856208430.302.2e-02Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Showing 1 to 20 of 77 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_56432116 7.651 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrX_-_142966709 7.347 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr9_+_65141154 5.006 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr6_-_23248264 4.839 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_98422961 3.862 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr1_+_139454747 3.221 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr15_-_75894474 3.122 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr7_-_80115294 3.109 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr10_-_128180265 2.795 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_-_82244716 2.769 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr3_-_37724321 2.596 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr15_+_98571004 2.442 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr5_+_140607334 2.442 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_+_43785107 2.429 ENSMUST00000015540.2
 Cd83
CD83 antigen
chr3_+_146220955 2.153 ENSMUST00000039164.2
 Lpar3
lysophosphatidic acid receptor 3
chr3_+_130068390 2.139 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr8_-_4275886 2.012 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr13_+_94083490 1.991 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chrX_-_74373260 1.828 ENSMUST00000073067.4
ENSMUST00000037967.5
 Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr17_+_35241838 1.368 ENSMUST00000173731.1
 Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.8 4.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 3.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.6 3.2 GO:0051661 maintenance of centrosome location(GO:0051661)
1.0 3.1 GO:0006097 glyoxylate cycle(GO:0006097)
0.0 3.0 GO:0032526 response to retinoic acid(GO:0032526)
0.4 2.6 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.5 2.4 GO:0007386 compartment pattern specification(GO:0007386)
0.4 2.4 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.2 2.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 2.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.3 1.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 1.3 GO:0048539 bone marrow development(GO:0048539)
0.0 1.3 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.4 1.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.4 1.1 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.3 1.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 1.0 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.3 0.9 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.3 0.8 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 3.8 GO:0000776 kinetochore(GO:0000776)
0.6 3.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 2.6 GO:0005688 U6 snRNP(GO:0005688)
0.0 2.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.3 GO:0061574 ASAP complex(GO:0061574)
0.4 1.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.9 GO:0051233 spindle midzone(GO:0051233)
0.1 0.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.8 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.8 GO:0001772 immunological synapse(GO:0001772)
0.2 0.5 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.6 3.9 GO:0019841 retinol binding(GO:0019841)
0.0 3.2 GO:0005516 calmodulin binding(GO:0005516)
1.0 3.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.8 3.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.5 2.6 GO:0030621 U4 snRNA binding(GO:0030621)
0.8 2.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 2.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.0 GO:0051087 chaperone binding(GO:0051087)
0.1 1.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 1.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 0.8 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 0.6 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.5 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 0.5 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)