Motif ID: Six3_Six1_Six2

Z-value: 0.662

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six1mm10_v2_chr12_-_73047179_730471790.522.8e-05Click!
Six2mm10_v2_chr17_-_85688252_856882750.504.8e-05Click!
Six3mm10_v2_chr17_+_85620816_856208430.302.2e-02Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_56432116 7.651 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrX_-_142966709 7.347 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr9_+_65141154 5.006 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr6_-_23248264 4.839 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_98422961 3.862 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr1_+_139454747 3.221 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr15_-_75894474 3.122 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr7_-_80115294 3.109 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr10_-_128180265 2.795 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_-_82244716 2.769 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr3_-_37724321 2.596 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr15_+_98571004 2.442 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr5_+_140607334 2.442 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_+_43785107 2.429 ENSMUST00000015540.2
 Cd83
CD83 antigen
chr3_+_146220955 2.153 ENSMUST00000039164.2
 Lpar3
lysophosphatidic acid receptor 3
chr3_+_130068390 2.139 ENSMUST00000076703.6
 Gm9396
predicted gene 9396
chr8_-_4275886 2.012 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr13_+_94083490 1.991 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chrX_-_74373260 1.828 ENSMUST00000073067.4
ENSMUST00000037967.5
 Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr17_+_35241838 1.368 ENSMUST00000173731.1
 Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr5_+_21543525 1.257 ENSMUST00000035651.4
 Lrrc17
leucine rich repeat containing 17
chr17_+_35241746 1.247 ENSMUST00000068056.5
ENSMUST00000174757.1
 Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr9_+_104002546 1.195 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chrX_-_74373218 1.186 ENSMUST00000178691.1
ENSMUST00000114146.1
 Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr10_+_24595623 1.138 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr13_+_104229366 1.061 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr5_-_62765618 0.996 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_121839460 0.967 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chr1_+_136467958 0.942 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr4_+_134864536 0.878 ENSMUST00000030627.7
 Rhd
Rh blood group, D antigen
chr11_-_101987004 0.848 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr19_-_55315980 0.839 ENSMUST00000076891.5
 Zdhhc6
zinc finger, DHHC domain containing 6
chr15_-_76206309 0.784 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
 Plec


plectin


chr4_-_43030440 0.775 ENSMUST00000135660.1
 Stoml2
stomatin (Epb7.2)-like 2
chr7_+_30231884 0.762 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr14_+_57798182 0.750 ENSMUST00000111269.1
 Sap18
Sin3-associated polypeptide 18
chrX_+_169685191 0.739 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr2_-_13271268 0.706 ENSMUST00000137670.1
ENSMUST00000114791.2
 Rsu1

Ras suppressor protein 1

chr12_+_30584429 0.682 ENSMUST00000057151.8
 Tmem18
transmembrane protein 18
chr17_+_40811089 0.676 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr11_-_69695521 0.659 ENSMUST00000181261.1
 Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr7_-_101903783 0.642 ENSMUST00000106969.1
 Tomt
transmembrane O-methyltransferase
chr2_-_13271419 0.626 ENSMUST00000028059.2
 Rsu1
Ras suppressor protein 1
chr14_+_57798156 0.576 ENSMUST00000128764.1
 Sap18
Sin3-associated polypeptide 18
chr5_+_104046869 0.546 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr8_+_69832633 0.520 ENSMUST00000131637.2
ENSMUST00000081503.6
 Pbx4

pre B cell leukemia homeobox 4

chr7_-_141168671 0.496 ENSMUST00000106033.3
 Rnh1
ribonuclease/angiogenin inhibitor 1
chr12_+_84773262 0.470 ENSMUST00000021667.5
 Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr8_-_106573461 0.459 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr17_-_53539411 0.443 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr6_-_115675871 0.402 ENSMUST00000112949.1
 Raf1
v-raf-leukemia viral oncogene 1
chr4_+_133176336 0.391 ENSMUST00000105912.1
 Wasf2
WAS protein family, member 2
chr3_+_88207308 0.377 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chr7_+_30232310 0.354 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr16_-_11203259 0.337 ENSMUST00000119953.1
 Rsl1d1
ribosomal L1 domain containing 1
chr1_-_118982551 0.334 ENSMUST00000159678.1
 Gli2
GLI-Kruppel family member GLI2
chr9_+_72958785 0.321 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr19_+_8764934 0.306 ENSMUST00000184663.1
 Nxf1
nuclear RNA export factor 1
chr13_-_74292297 0.306 ENSMUST00000109640.1
ENSMUST00000022059.7
 Ahrr

aryl-hydrocarbon receptor repressor

chr6_+_38534823 0.280 ENSMUST00000019833.4
 1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr10_+_100488289 0.267 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr2_+_117249725 0.236 ENSMUST00000028825.4
 Fam98b
family with sequence similarity 98, member B
chr11_-_99230998 0.231 ENSMUST00000103133.3
 Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr1_-_119504736 0.216 ENSMUST00000004565.8
 Ralb
v-ral simian leukemia viral oncogene homolog B (ras related)
chr8_+_71951038 0.211 ENSMUST00000131237.1
ENSMUST00000136516.1
ENSMUST00000109997.2
ENSMUST00000132848.1
 Zfp961



zinc finger protein 961



chr2_+_158028481 0.200 ENSMUST00000103123.3
 Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr4_+_11758147 0.192 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chrY_-_6237995 0.177 ENSMUST00000177612.1
 Gm21746
predicted gene, 21746
chr7_+_43690418 0.145 ENSMUST00000056329.6
 Klk14
kallikrein related-peptidase 14
chr9_-_36797273 0.105 ENSMUST00000163192.3
 Ei24
etoposide induced 2.4 mRNA
chr17_-_36951636 0.087 ENSMUST00000040402.7
ENSMUST00000174711.1
 Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr14_+_58893465 0.072 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr17_+_56717759 0.063 ENSMUST00000002452.6
 Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr9_-_36797303 0.051 ENSMUST00000115086.5
 Ei24
etoposide induced 2.4 mRNA
chr16_+_11203375 0.049 ENSMUST00000181526.1
 2610020C07Rik
RIKEN cDNA 2610020C07 gene
chr11_-_87826023 0.019 ENSMUST00000103177.3
 Lpo
lactoperoxidase
chr8_+_84831522 0.019 ENSMUST00000036734.5
 Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0006097 glyoxylate cycle(GO:0006097)
1.0 3.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.8 4.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 3.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.5 2.4 GO:0007386 compartment pattern specification(GO:0007386)
0.4 2.4 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.4 1.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.4 2.6 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.4 1.1 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.3 1.3 GO:0048539 bone marrow development(GO:0048539)
0.3 0.9 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.3 1.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 1.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.3 0.8 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.2 0.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 0.5 GO:0046032 ADP catabolic process(GO:0046032)
0.2 2.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.6 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 2.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.4 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.1 0.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.3 GO:0060032 notochord regression(GO:0060032)
0.1 0.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 5.2 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 3.0 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.3 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.0 0.1 GO:0007320 insemination(GO:0007320)
0.0 0.4 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 1.3 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 1.0 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.2 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.3 GO:2000772 regulation of cellular senescence(GO:2000772)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0036449 microtubule minus-end(GO:0036449)
0.4 1.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.2 2.6 GO:0005688 U6 snRNP(GO:0005688)
0.2 0.5 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 1.3 GO:0061574 ASAP complex(GO:0061574)
0.1 7.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.9 GO:0051233 spindle midzone(GO:0051233)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.8 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0097542 ciliary tip(GO:0097542)
0.0 3.8 GO:0000776 kinetochore(GO:0000776)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 1.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.8 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 2.4 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.8 2.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.8 3.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.6 3.9 GO:0019841 retinol binding(GO:0019841)
0.5 2.6 GO:0030621 U4 snRNA binding(GO:0030621)
0.4 2.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 0.8 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 0.6 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 1.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.5 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 0.5 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 4.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.0 GO:0051087 chaperone binding(GO:0051087)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.5 GO:0051537 ferrous iron binding(GO:0008198) 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 3.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)