Motif ID: Six4

Z-value: 0.557


Transcription factors associated with Six4:

Gene SymbolEntrez IDGene Name
Six4 ENSMUSG00000034460.8 Six4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.238.6e-02Click!


Activity profile for motif Six4.

activity profile for motif Six4


Sorted Z-values histogram for motif Six4

Sorted Z-values for motif Six4



Network of associatons between targets according to the STRING database.



First level regulatory network of Six4

PNG image of the network

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Top targets:


Showing 1 to 20 of 66 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_137314394 8.048 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr6_-_23248264 6.850 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_143460989 3.615 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_-_134018829 3.446 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr7_-_132317198 2.250 ENSMUST00000080215.5
 Chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr7_+_29307924 2.172 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr12_-_57546121 2.160 ENSMUST00000044380.6
 Foxa1
forkhead box A1
chr7_+_29309429 2.147 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr8_-_84237042 1.986 ENSMUST00000039480.5
 Zswim4
zinc finger SWIM-type containing 4
chr19_+_8764934 1.858 ENSMUST00000184663.1
 Nxf1
nuclear RNA export factor 1
chr6_+_7555053 1.842 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr11_+_67078293 1.772 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
 Myh3


myosin, heavy polypeptide 3, skeletal muscle, embryonic


chr2_-_103797617 1.648 ENSMUST00000028607.6
 Caprin1
cell cycle associated protein 1
chr1_-_78968079 1.580 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr13_+_73626886 1.484 ENSMUST00000022104.7
 Tert
telomerase reverse transcriptase
chr7_+_38183787 1.392 ENSMUST00000067854.8
ENSMUST00000177983.1
 1600014C10Rik

RIKEN cDNA 1600014C10 gene

chr8_-_85067982 1.295 ENSMUST00000177563.1
 Gm5741
predicted gene 5741
chr14_-_89898466 1.069 ENSMUST00000081204.4
 Gm10110
predicted gene 10110
chr1_-_180813534 1.024 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chr5_-_145191511 0.985 ENSMUST00000161845.1
 Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 3.6 GO:0060065 uterus development(GO:0060065)
0.4 3.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 2.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 2.3 GO:0019319 hexose biosynthetic process(GO:0019319)
0.7 2.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.6 1.8 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.1 1.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.5 1.5 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.4 1.5 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 1.1 GO:0006400 tRNA modification(GO:0006400)
0.2 1.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 1.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.0 GO:0009206 ATP biosynthetic process(GO:0006754) purine ribonucleoside triphosphate biosynthetic process(GO:0009206)
0.1 0.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.7 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.7 GO:0010955 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0 0.7 GO:0000281 mitotic cytokinesis(GO:0000281)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 4.3 GO:0071565 nBAF complex(GO:0071565)
0.0 2.2 GO:0005902 microvillus(GO:0005902)
0.1 1.9 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 1.8 GO:0032982 myosin filament(GO:0032982)
0.2 1.5 GO:0001740 Barr body(GO:0001740)
0.1 1.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.0 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.7 GO:0001651 dense fibrillar component(GO:0001651) box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258) microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 3.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 3.4 GO:0035198 miRNA binding(GO:0035198)
0.8 2.3 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 2.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 1.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.8 GO:0000146 microfilament motor activity(GO:0000146)
0.1 1.5 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.1 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.2 1.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.7 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)