Motif ID: Six4

Z-value: 0.557


Transcription factors associated with Six4:

Gene SymbolEntrez IDGene Name
Six4 ENSMUSG00000034460.8 Six4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.238.6e-02Click!


Activity profile for motif Six4.

activity profile for motif Six4


Sorted Z-values histogram for motif Six4

Sorted Z-values for motif Six4



Network of associatons between targets according to the STRING database.



First level regulatory network of Six4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_137314394 8.048 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr6_-_23248264 6.850 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_143460989 3.615 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_-_134018829 3.446 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr7_-_132317198 2.250 ENSMUST00000080215.5
 Chst15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr7_+_29307924 2.172 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr12_-_57546121 2.160 ENSMUST00000044380.6
 Foxa1
forkhead box A1
chr7_+_29309429 2.147 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr8_-_84237042 1.986 ENSMUST00000039480.5
 Zswim4
zinc finger SWIM-type containing 4
chr19_+_8764934 1.858 ENSMUST00000184663.1
 Nxf1
nuclear RNA export factor 1
chr6_+_7555053 1.842 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr11_+_67078293 1.772 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
 Myh3


myosin, heavy polypeptide 3, skeletal muscle, embryonic


chr2_-_103797617 1.648 ENSMUST00000028607.6
 Caprin1
cell cycle associated protein 1
chr1_-_78968079 1.580 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr13_+_73626886 1.484 ENSMUST00000022104.7
 Tert
telomerase reverse transcriptase
chr7_+_38183787 1.392 ENSMUST00000067854.8
ENSMUST00000177983.1
 1600014C10Rik

RIKEN cDNA 1600014C10 gene

chr8_-_85067982 1.295 ENSMUST00000177563.1
 Gm5741
predicted gene 5741
chr14_-_89898466 1.069 ENSMUST00000081204.4
 Gm10110
predicted gene 10110
chr1_-_180813534 1.024 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chr5_-_145191511 0.985 ENSMUST00000161845.1
 Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr13_-_9878998 0.963 ENSMUST00000063093.9
 Chrm3
cholinergic receptor, muscarinic 3, cardiac
chr8_+_62951361 0.955 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr8_+_95703037 0.931 ENSMUST00000073139.7
ENSMUST00000080666.7
 Ndrg4

N-myc downstream regulated gene 4

chrX_-_139714481 0.917 ENSMUST00000183728.1
 Gm15013
predicted gene 15013
chr6_+_149130170 0.897 ENSMUST00000087348.3
 Gm10203
predicted gene 10203
chr17_+_35049966 0.842 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr1_+_37890477 0.823 ENSMUST00000027256.5
 Mrpl30
mitochondrial ribosomal protein L30
chr2_-_91444622 0.741 ENSMUST00000064652.7
ENSMUST00000102594.4
ENSMUST00000094835.2
 1110051M20Rik


RIKEN cDNA 1110051M20 gene


chr2_+_119351222 0.739 ENSMUST00000028780.3
 Chac1
ChaC, cation transport regulator 1
chr3_-_129831374 0.724 ENSMUST00000029643.8
 Gar1
GAR1 ribonucleoprotein homolog (yeast)
chr6_+_50110186 0.709 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
 Mpp6


membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)


chr1_-_37890333 0.704 ENSMUST00000139725.1
ENSMUST00000027257.8
 Mitd1

MIT, microtubule interacting and transport, domain containing 1

chr17_+_24896488 0.604 ENSMUST00000024978.6
 Nme3
NME/NM23 nucleoside diphosphate kinase 3
chr11_-_45955465 0.604 ENSMUST00000011398.6
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr8_+_94214567 0.587 ENSMUST00000079961.6
 Nup93
nucleoporin 93
chr13_+_54071815 0.566 ENSMUST00000021930.8
 Sfxn1
sideroflexin 1
chr19_-_38224096 0.522 ENSMUST00000067167.5
 Fra10ac1
FRA10AC1 homolog (human)
chr2_+_131133497 0.516 ENSMUST00000110225.1
 Gm11037
predicted gene 11037
chr11_-_45955183 0.495 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr2_-_10048580 0.483 ENSMUST00000026888.4
 Taf3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr9_-_57158288 0.476 ENSMUST00000065358.7
 Commd4
COMM domain containing 4
chr1_-_180813591 0.450 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
 H3f3a


H3 histone, family 3A


chr3_+_145938004 0.442 ENSMUST00000039571.7
 2410004B18Rik
RIKEN cDNA 2410004B18 gene
chr2_+_22622183 0.429 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chrX_-_150440887 0.404 ENSMUST00000163233.1
 Tmem29
transmembrane protein 29
chr11_+_85312164 0.392 ENSMUST00000127717.1
 Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
chr6_+_134929089 0.388 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr6_+_134929118 0.337 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr6_+_124931378 0.320 ENSMUST00000032214.7
ENSMUST00000180095.1
 Mlf2

myeloid leukemia factor 2

chr12_-_21417356 0.312 ENSMUST00000103002.1
 Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr10_-_80918212 0.295 ENSMUST00000057623.7
ENSMUST00000179022.1
 Lmnb2

lamin B2

chr3_-_101604580 0.290 ENSMUST00000036493.6
 Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr13_+_51645232 0.213 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr19_+_6400523 0.190 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr3_+_40950631 0.185 ENSMUST00000048490.6
 Larp1b
La ribonucleoprotein domain family, member 1B
chr12_+_75818294 0.159 ENSMUST00000143031.1
ENSMUST00000044217.9
ENSMUST00000150317.1
 Syne2


spectrin repeat containing, nuclear envelope 2


chr16_+_11405648 0.150 ENSMUST00000096273.2
 Snx29
sorting nexin 29
chr9_-_70503718 0.138 ENSMUST00000034739.5
 Rnf111
ring finger 111
chr15_-_79834323 0.136 ENSMUST00000177316.2
ENSMUST00000175858.2
 Nptxr

neuronal pentraxin receptor

chr19_-_6980420 0.136 ENSMUST00000070878.8
ENSMUST00000177752.1
 Fkbp2

FK506 binding protein 2

chr15_-_79834224 0.107 ENSMUST00000109623.1
ENSMUST00000109625.1
ENSMUST00000023060.6
ENSMUST00000089299.5
 Cbx6

Npcd

chromobox 6

neuronal pentraxin chromo domain

chr1_-_74284636 0.098 ENSMUST00000178235.1
ENSMUST00000006462.7
 Aamp

angio-associated migratory protein

chr19_+_6400611 0.096 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr13_-_93674300 0.089 ENSMUST00000015941.7
 Bhmt2
betaine-homocysteine methyltransferase 2
chr18_+_60212080 0.016 ENSMUST00000031549.5
 Gm4951
predicted gene 4951
chr1_+_74284930 0.012 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
 Pnkd


paroxysmal nonkinesiogenic dyskinesia



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 2.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.6 1.8 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.5 1.5 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.4 3.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 1.5 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.2 3.6 GO:0060065 uterus development(GO:0060065)
0.2 1.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 2.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.4 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 1.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 0.3 GO:1903416 response to glycoside(GO:1903416)
0.1 0.6 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.1 1.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.7 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 2.3 GO:0019319 hexose biosynthetic process(GO:0019319)
0.0 0.5 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.7 GO:0010955 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 1.1 GO:0006400 tRNA modification(GO:0006400)
0.0 0.1 GO:0071267 amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 1.0 GO:0009206 ATP biosynthetic process(GO:0006754) purine ribonucleoside triphosphate biosynthetic process(GO:0009206)
0.0 0.6 GO:0006826 iron ion transport(GO:0006826)
0.0 0.7 GO:0000281 mitotic cytokinesis(GO:0000281)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0001740 Barr body(GO:0001740)
0.2 1.8 GO:0032982 myosin filament(GO:0032982)
0.2 4.3 GO:0071565 nBAF complex(GO:0071565)
0.1 0.7 GO:0001651 dense fibrillar component(GO:0001651) box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 1.9 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 1.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 5.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.0 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 2.2 GO:0005902 microvillus(GO:0005902)
0.0 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258) microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.3 3.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 3.4 GO:0035198 miRNA binding(GO:0035198)
0.2 1.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.5 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 1.1 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.1 0.3 GO:1990239 steroid hormone binding(GO:1990239)
0.1 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.8 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.4 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.4 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0001847 opsonin receptor activity(GO:0001847)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 14.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 2.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.7 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.8 GO:0005254 chloride channel activity(GO:0005254)