Motif ID: Six6

Z-value: 0.591


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_729397580.256.0e-02Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Showing 1 to 20 of 171 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.685 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr9_-_114564315 4.285 ENSMUST00000111816.2
Trim71
tripartite motif-containing 71
chr1_+_45311538 3.820 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr11_-_102365111 3.819 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr7_+_46847128 3.296 ENSMUST00000005051.4
Ldha
lactate dehydrogenase A
chr1_+_74713551 3.224 ENSMUST00000027356.5
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr5_+_21543525 3.074 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chrX_-_142966709 3.061 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr18_+_56432116 2.835 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr5_+_140607334 2.601 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_+_67234620 2.549 ENSMUST00000176029.1
Ebf2
early B cell factor 2
chr4_+_134864536 2.522 ENSMUST00000030627.7
Rhd
Rh blood group, D antigen
chr11_+_98412461 2.505 ENSMUST00000058295.5
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr1_-_165708088 1.883 ENSMUST00000040357.8
ENSMUST00000097474.3
Rcsd1

RCSD domain containing 1

chr15_+_98571004 1.802 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr13_+_43785107 1.757 ENSMUST00000015540.2
Cd83
CD83 antigen
chr9_+_98422961 1.745 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr3_-_37724321 1.666 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr12_+_52097737 1.646 ENSMUST00000040090.9
Nubpl
nucleotide binding protein-like
chr18_-_88927447 1.630 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 4.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.8 4.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.8 3.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 3.8 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.7 3.5 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.7 3.3 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.8 3.1 GO:0048539 bone marrow development(GO:0048539)
0.0 2.7 GO:0008203 cholesterol metabolic process(GO:0008203)
0.5 2.6 GO:0007386 compartment pattern specification(GO:0007386)
0.8 2.5 GO:0044849 estrous cycle(GO:0044849)
0.2 2.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 2.5 GO:0007338 single fertilization(GO:0007338)
0.3 2.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 1.9 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 1.9 GO:0032526 response to retinoic acid(GO:0032526)
0.3 1.8 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.4 1.7 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 1.7 GO:0018345 protein palmitoylation(GO:0018345)
0.1 1.6 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 4.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 3.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 3.8 GO:0014704 intercalated disc(GO:0014704)
0.2 3.5 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 3.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 3.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.5 GO:0043219 lateral loop(GO:0043219)
0.2 2.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 2.2 GO:0000776 kinetochore(GO:0000776)
0.0 1.6 GO:0005801 cis-Golgi network(GO:0005801)
0.5 1.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 1.1 GO:0000815 ESCRT III complex(GO:0000815)
0.1 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.0 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.0 GO:0042555 MCM complex(GO:0042555)
0.0 1.0 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 5.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 4.3 GO:0035198 miRNA binding(GO:0035198)
0.3 3.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 3.5 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.8 3.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.3 3.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 2.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.9 2.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 2.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 2.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.4 2.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 2.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.5 1.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 1.9 GO:0051015 actin filament binding(GO:0051015)
0.3 1.7 GO:0019841 retinol binding(GO:0019841)
0.1 1.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.4 1.5 GO:0042903 tubulin deacetylase activity(GO:0042903)