Motif ID: Smad1

Z-value: 1.608


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.572.0e-06Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_73483602 17.839 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr7_-_103843154 9.664 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr6_-_55175019 8.234 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr11_+_32296489 7.734 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr10_+_79988584 6.756 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr6_+_4504814 6.401 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr2_+_93642307 6.040 ENSMUST00000042078.3
ENSMUST00000111254.1
 Alx4

aristaless-like homeobox 4

chr12_+_109452833 5.997 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr19_+_20601958 5.488 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr8_+_104101625 5.282 ENSMUST00000034339.8
 Cdh5
cadherin 5
chr19_-_24031006 5.134 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr9_-_114564315 4.933 ENSMUST00000111816.2
 Trim71
tripartite motif-containing 71
chr7_-_142576492 4.666 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA
chr1_-_171234290 4.506 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr6_-_23248264 4.499 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_-_107943705 4.145 ENSMUST00000106680.1
ENSMUST00000106684.1
ENSMUST00000106685.2
 Gstm6


glutathione S-transferase, mu 6


chr7_-_103813913 3.962 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr4_-_72852622 3.751 ENSMUST00000179234.1
ENSMUST00000078617.4
 Aldoart1

aldolase 1 A, retrogene 1

chr7_-_25882407 3.707 ENSMUST00000163316.2
 Gm6434
predicted gene 6434
chr9_+_54764748 3.698 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 775 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 20.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.3 16.7 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.0 13.7 GO:0006412 translation(GO:0006412)
0.5 11.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.3 11.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.9 9.7 GO:0015671 oxygen transport(GO:0015671)
0.8 7.9 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.4 7.8 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.4 7.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.2 6.7 GO:0048821 erythrocyte development(GO:0048821)
0.2 6.3 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.4 6.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.9 6.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
2.0 6.0 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 5.9 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
1.4 5.8 GO:0048819 regulation of hair follicle maturation(GO:0048819) regulation of catagen(GO:0051794)
1.8 5.5 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
1.1 5.5 GO:0015705 iodide transport(GO:0015705)
0.4 5.5 GO:0043589 skin morphogenesis(GO:0043589)
0.1 5.4 GO:0048844 artery morphogenesis(GO:0048844)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 306 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 47.2 GO:0070062 extracellular exosome(GO:0070062)
0.2 45.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 25.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 24.3 GO:0072562 blood microparticle(GO:0072562)
0.1 20.6 GO:0005925 focal adhesion(GO:0005925)
0.0 18.3 GO:0005667 transcription factor complex(GO:0005667)
0.3 17.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
3.8 15.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 11.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 11.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
2.4 9.7 GO:0005833 hemoglobin complex(GO:0005833)
0.7 8.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 8.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 8.3 GO:0031012 extracellular matrix(GO:0031012)
0.2 7.5 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 7.3 GO:0031526 brush border membrane(GO:0031526)
0.5 7.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 6.7 GO:0016324 apical plasma membrane(GO:0016324)
2.1 6.4 GO:0005584 collagen type I trimer(GO:0005584)
0.1 6.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 510 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 41.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 25.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.6 22.6 GO:0004364 glutathione transferase activity(GO:0004364)
4.3 17.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 14.7 GO:0008201 heparin binding(GO:0008201)
0.3 12.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 11.7 GO:0071837 HMG box domain binding(GO:0071837)
0.6 9.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 8.8 GO:0005178 integrin binding(GO:0005178)
0.1 8.5 GO:0008172 S-methyltransferase activity(GO:0008172)
1.3 8.0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.6 7.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
3.9 7.7 GO:0031720 haptoglobin binding(GO:0031720)
1.9 7.7 GO:0019763 immunoglobulin receptor activity(GO:0019763)
1.4 7.2 GO:0002060 purine nucleobase binding(GO:0002060)
0.3 7.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 6.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
1.0 6.3 GO:0016918 retinal binding(GO:0016918)
0.3 6.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
2.0 5.9 GO:0005534 galactose binding(GO:0005534)