Motif ID: Smad2

Z-value: 0.513


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.572.4e-06Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_12345847 3.860 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr9_-_119578981 2.465 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr8_-_87959560 2.120 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_-_55175019 2.087 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr7_-_116237767 1.739 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr3_+_89136133 1.564 ENSMUST00000047111.6
 Pklr
pyruvate kinase liver and red blood cell
chr19_+_59458372 1.460 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr3_+_127633134 1.362 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr3_+_89136572 1.291 ENSMUST00000107482.3
ENSMUST00000127058.1
 Pklr

pyruvate kinase liver and red blood cell

chr10_-_42583628 1.222 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr16_+_64851991 1.190 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr4_+_11191726 1.057 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr15_-_103251465 0.967 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr13_-_78199757 0.963 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr7_+_82867327 0.961 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr17_-_34615965 0.954 ENSMUST00000097345.3
ENSMUST00000015611.7
 Egfl8

EGF-like domain 8

chr7_-_45052865 0.916 ENSMUST00000057293.6
 Prr12
proline rich 12
chr13_+_23752267 0.837 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr7_-_34654342 0.829 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr5_-_113800356 0.808 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119

chr10_-_37138863 0.774 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chrX_+_99821021 0.727 ENSMUST00000096363.2
 Tmem28
transmembrane protein 28
chr3_+_135438722 0.625 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr7_+_101321703 0.609 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr8_-_90908415 0.605 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chr17_+_7925990 0.581 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr12_+_33147693 0.580 ENSMUST00000077456.6
ENSMUST00000110824.2
 Atxn7l1

ataxin 7-like 1

chr17_-_25861456 0.573 ENSMUST00000079461.8
ENSMUST00000176923.1
 Wdr90

WD repeat domain 90

chrX_-_20931520 0.568 ENSMUST00000001156.7
 Cfp
complement factor properdin
chr10_+_80150448 0.547 ENSMUST00000153477.1
 Midn
midnolin
chr15_+_102102926 0.541 ENSMUST00000169627.1
ENSMUST00000046144.9
 Tenc1

tensin like C1 domain-containing phosphatase

chr2_-_148443543 0.540 ENSMUST00000099269.3
 Cd93
CD93 antigen
chr14_-_20496780 0.538 ENSMUST00000022353.3
 Mss51
MSS51 mitochondrial translational activator
chr7_-_29180699 0.515 ENSMUST00000059642.10
 Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr7_-_29180454 0.512 ENSMUST00000182328.1
 Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr11_+_101119938 0.507 ENSMUST00000043680.8
 Tubg1
tubulin, gamma 1
chr2_+_156863110 0.499 ENSMUST00000029165.3
 1110008F13Rik
RIKEN cDNA 1110008F13 gene
chr8_+_109705549 0.473 ENSMUST00000034163.8
 Zfp821
zinc finger protein 821
chr2_-_91950386 0.421 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chrX_-_7947848 0.415 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
 Hdac6


histone deacetylase 6


chr8_-_105637403 0.404 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr11_-_116654245 0.398 ENSMUST00000021166.5
 Cygb
cytoglobin
chr6_-_142702259 0.382 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
 Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr14_-_31168587 0.367 ENSMUST00000036618.7
 Stab1
stabilin 1
chr14_-_18331855 0.357 ENSMUST00000022296.6
 Ube2e1
ubiquitin-conjugating enzyme E2E 1
chr9_+_53771499 0.346 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr6_+_83137089 0.318 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr4_+_11191354 0.312 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr11_-_33147400 0.311 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr6_+_125009665 0.295 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
 Zfp384




zinc finger protein 384




chr17_-_35700520 0.289 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr4_-_155010984 0.281 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr11_-_75190458 0.268 ENSMUST00000044949.4
 Dph1
DPH1 homolog (S. cerevisiae)
chr8_-_105637350 0.241 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chrX_-_7947763 0.228 ENSMUST00000154244.1
 Hdac6
histone deacetylase 6
chr13_-_104816908 0.228 ENSMUST00000022228.6
 Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr11_+_69846665 0.213 ENSMUST00000019605.2
 Plscr3
phospholipid scramblase 3
chr11_+_69846610 0.209 ENSMUST00000152566.1
ENSMUST00000108633.2
 Plscr3

phospholipid scramblase 3

chr2_-_128967725 0.199 ENSMUST00000099385.2
 Gm10762
predicted gene 10762
chr10_-_49788743 0.199 ENSMUST00000105483.1
ENSMUST00000105487.1
 Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr4_-_129261394 0.188 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr13_+_104817171 0.185 ENSMUST00000022230.8
 Srek1ip1
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chr4_+_117849193 0.181 ENSMUST00000132043.2
ENSMUST00000169990.1
 Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr18_-_42579652 0.141 ENSMUST00000054738.3
 Gpr151
G protein-coupled receptor 151
chr3_+_135438280 0.129 ENSMUST00000106291.3
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr4_+_117849361 0.124 ENSMUST00000163288.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr17_-_35980197 0.102 ENSMUST00000055454.7
 Prr3
proline-rich polypeptide 3
chr14_+_21500879 0.085 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chrX_-_136741155 0.075 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
 Morf4l2




mortality factor 4 like 2




chr10_+_80151154 0.070 ENSMUST00000146516.1
ENSMUST00000144526.1
 Midn

midnolin

chr18_+_11839220 0.034 ENSMUST00000171109.1
ENSMUST00000046948.8
 Cables1

CDK5 and Abl enzyme substrate 1

chr17_+_3397189 0.023 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr11_-_101119814 0.013 ENSMUST00000107295.3
 Fam134c
family with sequence similarity 134, member C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
0.6 3.9 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 2.9 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.3 1.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.2 GO:0021764 amygdala development(GO:0021764)
0.2 1.0 GO:0072697 protein localization to cell cortex(GO:0072697)
0.2 0.6 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.2 0.8 GO:1903012 positive regulation of bone development(GO:1903012)
0.2 2.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.6 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 1.0 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.4 GO:0015671 oxygen transport(GO:0015671)
0.1 0.3 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 1.0 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 1.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 2.0 GO:0009308 amine metabolic process(GO:0009308)
0.0 1.4 GO:0021954 central nervous system neuron development(GO:0021954)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0042585 germinal vesicle(GO:0042585)
0.2 1.7 GO:0005915 zonula adherens(GO:0005915)
0.2 2.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 1.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.5 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0004743 pyruvate kinase activity(GO:0004743)
0.4 2.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 0.6 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 1.7 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.4 GO:0004096 catalase activity(GO:0004096)
0.1 1.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.4 GO:0001727 lipid kinase activity(GO:0001727)
0.0 1.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 6.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.4 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 1.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 2.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.8 GO:0005080 protein kinase C binding(GO:0005080)