Motif ID: Smad2

Z-value: 0.513


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.572.4e-06Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Showing 1 to 20 of 73 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_12345847 3.860 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr9_-_119578981 2.465 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr8_-_87959560 2.120 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_-_55175019 2.087 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr7_-_116237767 1.739 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr3_+_89136133 1.564 ENSMUST00000047111.6
 Pklr
pyruvate kinase liver and red blood cell
chr19_+_59458372 1.460 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr3_+_127633134 1.362 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr3_+_89136572 1.291 ENSMUST00000107482.3
ENSMUST00000127058.1
 Pklr

pyruvate kinase liver and red blood cell

chr10_-_42583628 1.222 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr16_+_64851991 1.190 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr4_+_11191726 1.057 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr15_-_103251465 0.967 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr13_-_78199757 0.963 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr7_+_82867327 0.961 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr17_-_34615965 0.954 ENSMUST00000097345.3
ENSMUST00000015611.7
 Egfl8

EGF-like domain 8

chr7_-_45052865 0.916 ENSMUST00000057293.6
 Prr12
proline rich 12
chr13_+_23752267 0.837 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr7_-_34654342 0.829 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr5_-_113800356 0.808 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.9 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 2.9 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.8 2.5 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
0.2 2.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 2.0 GO:0009308 amine metabolic process(GO:0009308)
0.3 1.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 1.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.4 GO:0021954 central nervous system neuron development(GO:0021954)
0.2 1.2 GO:0021764 amygdala development(GO:0021764)
0.2 1.0 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 1.0 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 1.0 GO:0043248 proteasome assembly(GO:0043248)
0.2 0.8 GO:1903012 positive regulation of bone development(GO:1903012)
0.0 0.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 0.6 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 0.6 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 1.7 GO:0005915 zonula adherens(GO:0005915)
0.1 1.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 0.8 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0005827 polar microtubule(GO:0005827)
0.1 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.0 2.9 GO:0004743 pyruvate kinase activity(GO:0004743)
0.4 2.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 2.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.7 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.4 GO:0070888 E-box binding(GO:0070888)
0.0 1.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.8 GO:0005080 protein kinase C binding(GO:0005080)
0.2 0.6 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.4 GO:0004096 catalase activity(GO:0004096)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.4 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)