Motif ID: Smad3

Z-value: 1.512


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63711969_63711994-0.682.7e-09Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_23533869 24.806 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_22042949 24.646 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr13_-_21833575 20.386 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr13_-_22035589 19.783 ENSMUST00000091742.4
 Hist1h2ah
histone cluster 1, H2ah
chr13_-_21787218 17.011 ENSMUST00000091751.2
 Hist1h2an
histone cluster 1, H2an
chr15_+_81936753 15.330 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr15_+_81936911 14.903 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr13_+_21810428 14.798 ENSMUST00000091745.5
 Hist1h2ao
histone cluster 1, H2ao
chr13_-_23571151 14.634 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae
chr14_-_62456286 13.768 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr19_+_5740885 11.664 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr13_-_21832194 10.509 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr6_-_36811361 10.349 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr1_-_134235420 10.005 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr2_-_173276144 9.162 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr11_+_58954675 9.026 ENSMUST00000047697.5
ENSMUST00000108817.3
 Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr13_-_21750505 8.547 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr13_+_23581563 8.520 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr13_+_23531044 8.514 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr15_-_81697256 7.657 ENSMUST00000072910.5
 Chadl
chondroadherin-like
chr11_-_116110211 6.933 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr12_+_12911986 6.653 ENSMUST00000085720.1
 Rpl36-ps3
ribosomal protein L36, pseudogene 3
chr13_-_23551648 6.581 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr2_-_104257400 5.952 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr4_+_140986873 5.664 ENSMUST00000168047.1
ENSMUST00000037055.7
ENSMUST00000127833.2
 Atp13a2


ATPase type 13A2


chr1_+_172341197 5.588 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr2_+_178193075 5.377 ENSMUST00000103065.1
 Phactr3
phosphatase and actin regulator 3
chr9_-_106656081 5.358 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr13_+_21735055 5.314 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr1_-_126492683 5.210 ENSMUST00000162877.1
 Nckap5
NCK-associated protein 5
chr17_-_27623263 5.126 ENSMUST00000062397.6
ENSMUST00000176876.1
 Nudt3

nudix (nucleotide diphosphate linked moiety X)-type motif 3

chr6_+_136808248 5.126 ENSMUST00000074556.4
 H2afj
H2A histone family, member J
chr13_+_22043189 5.095 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr13_+_23571382 5.075 ENSMUST00000079251.5
 Hist1h2bg
histone cluster 1, H2bg
chr12_+_100779074 4.968 ENSMUST00000110073.1
ENSMUST00000110070.1
 9030617O03Rik

RIKEN cDNA 9030617O03 gene

chr14_+_32028989 4.890 ENSMUST00000022460.4
 Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr16_-_45158183 4.569 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr1_-_126492900 4.517 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chr11_-_102447647 4.476 ENSMUST00000049057.4
 Fam171a2
family with sequence similarity 171, member A2
chr13_-_23683941 4.330 ENSMUST00000171127.1
 Hist1h2ac
histone cluster 1, H2ac
chr13_+_21787461 4.269 ENSMUST00000110473.2
ENSMUST00000102982.1
 Hist1h2bp

histone cluster 1, H2bp

chr19_-_23448322 4.239 ENSMUST00000036069.6
 Mamdc2
MAM domain containing 2
chr4_+_102570065 4.172 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr13_+_22035821 4.018 ENSMUST00000110455.2
 Hist1h2bk
histone cluster 1, H2bk
chr7_+_44384803 3.916 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr13_+_23684192 3.915 ENSMUST00000018246.4
 Hist1h2bc
histone cluster 1, H2bc
chr13_+_21833736 3.869 ENSMUST00000180288.1
ENSMUST00000110467.1
 Hist1h2br

histone cluster 1 H2br

chr14_+_119138415 3.746 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr17_-_27623441 3.674 ENSMUST00000025050.5
 Nudt3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chrX_+_10485121 3.268 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr6_+_129533183 2.715 ENSMUST00000032264.6
 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr13_-_21810190 2.695 ENSMUST00000110469.1
ENSMUST00000091749.2
 Hist1h2bq

histone cluster 1, H2bq

chr14_+_64589802 2.349 ENSMUST00000180610.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr15_-_58823530 1.994 ENSMUST00000072113.5
 Tmem65
transmembrane protein 65
chr9_+_69454066 1.847 ENSMUST00000134907.1
 Anxa2
annexin A2
chr10_+_33905015 1.768 ENSMUST00000169670.1
 Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chrX_-_20291776 1.750 ENSMUST00000072451.4
 Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr1_+_75210832 1.706 ENSMUST00000027401.4
ENSMUST00000144355.1
ENSMUST00000123825.1
 Stk16


serine/threonine kinase 16


chr4_+_130055010 1.548 ENSMUST00000123617.1
 Col16a1
collagen, type XVI, alpha 1
chr2_-_30194112 1.535 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr13_+_23746734 1.438 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr16_-_15594507 1.406 ENSMUST00000115776.1
ENSMUST00000115777.3
 Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr16_-_15594472 1.405 ENSMUST00000118236.1
ENSMUST00000096234.3
 Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr17_-_6827990 1.398 ENSMUST00000181895.1
 Gm2885
predicted gene 2885
chr10_-_120979327 1.353 ENSMUST00000119944.1
ENSMUST00000119093.1
 Lemd3

LEM domain containing 3

chr5_+_34543365 1.282 ENSMUST00000101316.3
 Sh3bp2
SH3-domain binding protein 2
chr9_+_21196705 1.270 ENSMUST00000003395.9
 Pde4a
phosphodiesterase 4A, cAMP specific
chr9_-_20879718 1.266 ENSMUST00000043726.6
 Angptl6
angiopoietin-like 6
chrX_-_144688180 1.188 ENSMUST00000040184.3
 Trpc5
transient receptor potential cation channel, subfamily C, member 5
chr6_-_129533267 1.078 ENSMUST00000181594.1
 1700101I11Rik
RIKEN cDNA 1700101I11 gene
chrX_-_150814265 1.068 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
 Maged2


melanoma antigen, family D, 2


chr3_-_107760221 0.887 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr2_+_129065934 0.874 ENSMUST00000035812.7
 Ttl
tubulin tyrosine ligase
chr7_-_24316590 0.761 ENSMUST00000108436.1
ENSMUST00000032673.8
 Zfp94

zinc finger protein 94

chr1_+_146497614 0.736 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr9_-_66514567 0.600 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr9_+_109038565 0.566 ENSMUST00000112059.3
ENSMUST00000026737.5
 Shisa5

shisa homolog 5 (Xenopus laevis)

chr1_-_75210732 0.552 ENSMUST00000113623.1
 Glb1l
galactosidase, beta 1-like
chrX_+_143664290 0.526 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr11_-_87828289 0.439 ENSMUST00000136446.1
 Lpo
lactoperoxidase
chr12_+_119945957 0.387 ENSMUST00000058644.8
 Tmem196
transmembrane protein 196
chrX_-_95026671 0.374 ENSMUST00000096367.3
 Spin4
spindlin family, member 4
chr1_-_23909687 0.330 ENSMUST00000129254.1
 Smap1
small ArfGAP 1
chr11_+_46436925 0.321 ENSMUST00000152119.1
ENSMUST00000140027.1
ENSMUST00000020665.6
ENSMUST00000170928.1
ENSMUST00000109231.1
ENSMUST00000109232.3
ENSMUST00000128940.1
 Med7






mediator complex subunit 7






chr12_-_12941827 0.280 ENSMUST00000043396.7
 Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr7_-_100964371 0.219 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_+_82867327 0.171 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr5_+_75574916 0.149 ENSMUST00000144270.1
ENSMUST00000005815.6
 Kit

kit oncogene

chrX_+_143664365 0.108 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr13_-_92354943 0.091 ENSMUST00000022220.6
 Msh3
mutS homolog 3 (E. coli)
chr2_-_152831665 0.083 ENSMUST00000156688.1
ENSMUST00000007803.5
 Bcl2l1

BCL2-like 1

chr11_-_79254663 0.046 ENSMUST00000017821.5
 Wsb1
WD repeat and SOCS box-containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.7 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
3.4 10.3 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
3.3 10.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
2.9 8.8 GO:0071544 diphosphoinositol polyphosphate metabolic process(GO:0071543) diphosphoinositol polyphosphate catabolic process(GO:0071544)
2.6 7.7 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
2.5 48.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.9 5.6 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
1.8 9.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
1.4 5.7 GO:0007039 protein catabolic process in the vacuole(GO:0007039) peptidyl-aspartic acid modification(GO:0018197)
1.3 134.2 GO:0006342 chromatin silencing(GO:0006342)
1.1 13.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.9 2.8 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.6 3.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.5 13.8 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.5 4.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 1.2 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.3 4.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 5.8 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 0.9 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 2.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 5.4 GO:0014047 glutamate secretion(GO:0014047)
0.1 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.4 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 10.8 GO:0006334 nucleosome assembly(GO:0006334)
0.1 2.0 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.1 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 1.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 1.5 GO:0051894 integrin activation(GO:0033622) positive regulation of focal adhesion assembly(GO:0051894)
0.1 6.0 GO:0098792 xenophagy(GO:0098792)
0.0 0.1 GO:1905065 dendritic cell cytokine production(GO:0002371) hematopoietic stem cell migration(GO:0035701) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 22.1 GO:0006397 mRNA processing(GO:0006397)
0.0 1.8 GO:0003341 cilium movement(GO:0003341)
0.0 0.6 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 4.6 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.3 GO:2000369 positive regulation of erythrocyte differentiation(GO:0045648) regulation of clathrin-mediated endocytosis(GO:2000369)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 130.5 GO:0000786 nucleosome(GO:0000786)
1.5 13.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.9 2.8 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.6 1.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.5 10.0 GO:0032279 asymmetric synapse(GO:0032279)
0.4 5.6 GO:0097449 astrocyte projection(GO:0097449)
0.3 0.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 4.2 GO:0005614 interstitial matrix(GO:0005614)
0.2 5.7 GO:0005771 multivesicular body(GO:0005771)
0.2 9.2 GO:0031901 early endosome membrane(GO:0031901)
0.2 4.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 61.7 GO:0000790 nuclear chromatin(GO:0000790)
0.1 2.7 GO:0000421 autophagosome membrane(GO:0000421)
0.1 10.3 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 5.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 20.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.7 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 2.0 GO:0014704 intercalated disc(GO:0014704)
0.0 8.8 GO:0030133 transport vesicle(GO:0030133)
0.0 1.2 GO:0034704 calcium channel complex(GO:0034704)
0.0 4.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0032300 mismatch repair complex(GO:0032300)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.9 5.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
1.5 13.8 GO:0004383 guanylate cyclase activity(GO:0004383)
1.5 8.8 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
1.4 10.0 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
1.1 5.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.7 5.7 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.5 11.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.5 1.8 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.3 1.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 5.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 9.7 GO:0050699 WW domain binding(GO:0050699)
0.2 2.7 GO:0030957 Tat protein binding(GO:0030957)
0.2 4.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 46.0 GO:0042393 histone binding(GO:0042393)
0.2 4.6 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 3.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 5.4 GO:0030552 cAMP binding(GO:0030552)
0.1 7.7 GO:0005518 collagen binding(GO:0005518)
0.1 3.7 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 68.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 1.2 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 2.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 93.1 GO:0003677 DNA binding(GO:0003677)
0.0 0.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 4.2 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.9 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0004601 peroxidase activity(GO:0004601)