Motif ID: Smad4

Z-value: 0.964


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.047.5e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_22042949 6.184 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr10_-_127534540 5.509 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr13_-_21832194 4.493 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr11_-_95514570 3.934 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr19_+_5740885 3.761 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr13_+_23581563 3.490 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr7_-_70360593 3.203 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr1_-_16770138 2.829 ENSMUST00000071842.8
 Gm5828
predicted gene 5828
chr13_-_23551648 2.778 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr4_-_148130678 2.776 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr7_+_24862193 2.562 ENSMUST00000052897.4
ENSMUST00000170837.2
 Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr13_+_23531044 2.507 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr3_-_96220880 2.273 ENSMUST00000090782.3
 Hist2h2ac
histone cluster 2, H2ac
chr3_+_127633134 2.258 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr13_+_21735055 2.152 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr14_-_25903100 2.067 ENSMUST00000052286.8
 Plac9a
placenta specific 9a
chr13_+_22043189 2.032 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr12_+_103314944 1.944 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr11_-_89302545 1.892 ENSMUST00000061728.3
 Nog
noggin
chr10_+_80150448 1.890 ENSMUST00000153477.1
 Midn
midnolin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 15.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 8.5 GO:0006342 chromatin silencing(GO:0006342)
1.3 3.8 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.6 3.2 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.2 3.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 3.0 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 2.8 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.1 2.7 GO:0030903 notochord development(GO:0030903)
0.0 2.3 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 2.0 GO:0006334 nucleosome assembly(GO:0006334)
0.5 1.9 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.3 1.9 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.3 1.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 1.6 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.6 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.5 1.5 GO:0015889 cobalamin transport(GO:0015889)
0.3 1.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 1.5 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 1.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 21.8 GO:0000786 nucleosome(GO:0000786)
0.0 6.2 GO:0000790 nuclear chromatin(GO:0000790)
0.1 3.7 GO:0005581 collagen trimer(GO:0005581)
0.0 3.6 GO:0005667 transcription factor complex(GO:0005667)
1.0 3.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 1.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.2 0.9 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.4 GO:0042393 histone binding(GO:0042393)
1.1 4.4 GO:0050436 microfibril binding(GO:0050436)
0.0 4.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 4.2 GO:0005096 GTPase activator activity(GO:0005096)
0.2 3.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.4 3.2 GO:0001972 retinoic acid binding(GO:0001972)
0.1 2.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.2 GO:0019955 cytokine binding(GO:0019955)
0.0 2.0 GO:0070888 E-box binding(GO:0070888)
0.2 1.5 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 1.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.0 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.9 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.9 GO:0070628 proteasome binding(GO:0070628)