Motif ID: Snai1_Zeb1_Snai2

Z-value: 2.449

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.818.7e-15Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.237.3e-02Click!
Snai1mm10_v2_chr2_+_167538192_1675382100.038.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_29281977 22.308 ENSMUST00000098604.4
ENSMUST00000108236.3
Spint2

serine protease inhibitor, Kunitz type 2

chr13_-_57907587 21.287 ENSMUST00000172326.1
Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr4_+_85205417 19.968 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
Sh3gl2


SH3-domain GRB2-like 2


chr11_-_67922136 19.549 ENSMUST00000021288.3
ENSMUST00000108677.1
Usp43

ubiquitin specific peptidase 43

chr15_-_66831625 17.238 ENSMUST00000164163.1
Sla
src-like adaptor
chr5_-_147076482 17.231 ENSMUST00000016664.7
Lnx2
ligand of numb-protein X 2
chr18_-_61911783 15.435 ENSMUST00000049378.8
ENSMUST00000166783.1
Ablim3

actin binding LIM protein family, member 3

chr12_+_82616885 15.184 ENSMUST00000161801.1
Rgs6
regulator of G-protein signaling 6
chr19_-_57314896 14.600 ENSMUST00000111524.1
Ablim1
actin-binding LIM protein 1
chr3_+_75557530 13.587 ENSMUST00000161776.1
ENSMUST00000029423.8
Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr5_+_37028329 13.488 ENSMUST00000173836.1
Jakmip1
janus kinase and microtubule interacting protein 1
chr7_-_126704179 13.447 ENSMUST00000106364.1
Coro1a
coronin, actin binding protein 1A
chr4_+_85205120 13.267 ENSMUST00000107188.3
Sh3gl2
SH3-domain GRB2-like 2
chr7_+_44384803 12.682 ENSMUST00000120262.1
Syt3
synaptotagmin III
chr15_+_98634743 12.616 ENSMUST00000003442.7
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr8_+_3631109 12.488 ENSMUST00000004745.8
Stxbp2
syntaxin binding protein 2
chr2_-_84886692 12.214 ENSMUST00000054514.5
ENSMUST00000151799.1
Rtn4rl2

reticulon 4 receptor-like 2

chr11_-_100397740 12.189 ENSMUST00000001592.8
ENSMUST00000107403.1
Jup

junction plakoglobin

chr12_+_112722163 11.918 ENSMUST00000101018.3
ENSMUST00000179041.1
ENSMUST00000092279.6
Cep170b


centrosomal protein 170B


chr7_-_27446599 11.870 ENSMUST00000011895.7
Sptbn4
spectrin beta, non-erythrocytic 4

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 870 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 49.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
5.4 38.1 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
1.5 33.5 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.4 28.6 GO:0030032 lamellipodium assembly(GO:0030032)
7.8 23.3 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
1.0 20.5 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
1.8 20.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.7 20.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
4.3 17.0 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
1.9 17.0 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
3.3 16.5 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.6 15.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0 15.4 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
2.5 15.2 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.8 15.2 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.6 15.1 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.4 14.5 GO:0045022 early endosome to late endosome transport(GO:0045022)
1.5 13.8 GO:0071420 cellular response to histamine(GO:0071420)
2.3 13.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.0 13.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 314 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 82.2 GO:0043195 terminal bouton(GO:0043195)
0.4 79.2 GO:0045211 postsynaptic membrane(GO:0045211)
1.7 52.3 GO:0033268 node of Ranvier(GO:0033268)
1.0 48.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.5 38.1 GO:0001891 phagocytic cup(GO:0001891)
1.4 27.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 27.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 26.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 26.7 GO:0030427 site of polarized growth(GO:0030427)
0.4 25.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 21.2 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.5 19.8 GO:0044295 axonal growth cone(GO:0044295)
0.6 19.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 19.5 GO:0070382 exocytic vesicle(GO:0070382)
1.1 18.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.8 18.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.8 15.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
2.6 15.7 GO:0061689 tricellular tight junction(GO:0061689)
1.2 15.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 14.3 GO:0005776 autophagosome(GO:0005776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 518 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 35.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.0 35.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 32.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
1.1 30.7 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
3.0 30.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.9 28.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.1 27.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 25.4 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 24.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 22.1 GO:0005518 collagen binding(GO:0005518)
3.1 21.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.5 21.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.2 21.2 GO:0050811 GABA receptor binding(GO:0050811)
1.1 20.7 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
1.3 19.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 19.0 GO:0030165 PDZ domain binding(GO:0030165)
1.3 18.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.4 17.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.6 17.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3 17.4 GO:0048306 calcium-dependent protein binding(GO:0048306)