Motif ID: Sox1

Z-value: 0.313


Transcription factors associated with Sox1:

Gene SymbolEntrez IDGene Name
Sox1 ENSMUSG00000096014.1 Sox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox1mm10_v2_chr8_+_12395287_123952950.123.7e-01Click!


Activity profile for motif Sox1.

activity profile for motif Sox1


Sorted Z-values histogram for motif Sox1

Sorted Z-values for motif Sox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_120747248 1.263 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr14_-_30923547 1.083 ENSMUST00000170415.1
 Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr14_-_30923754 1.062 ENSMUST00000006697.8
 Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr8_+_13159135 0.959 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr5_+_21186267 0.782 ENSMUST00000036031.8
 Gsap
gamma-secretase activating protein
chr17_+_47737030 0.777 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr11_+_104282371 0.718 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chr3_-_34005490 0.634 ENSMUST00000060997.2
 Gm9791
predicted pseudogene 9791
chr15_-_75048837 0.611 ENSMUST00000179762.1
ENSMUST00000065408.9
 Ly6c1

lymphocyte antigen 6 complex, locus C1

chr9_-_114390633 0.594 ENSMUST00000084881.4
 Crtap
cartilage associated protein
chr17_+_34263209 0.584 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chrX_+_74297097 0.577 ENSMUST00000019231.5
ENSMUST00000147900.1
ENSMUST00000147275.1
ENSMUST00000114171.3
 Atp6ap1



ATPase, H+ transporting, lysosomal accessory protein 1



chr17_-_34287770 0.567 ENSMUST00000174751.1
ENSMUST00000040655.6
 H2-Aa

histocompatibility 2, class II antigen A, alpha

chr16_-_37654408 0.464 ENSMUST00000023514.3
 Ndufb4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr9_-_108305941 0.445 ENSMUST00000044725.7
 Tcta
T cell leukemia translocation altered gene
chr5_-_140649018 0.375 ENSMUST00000042661.3
 Ttyh3
tweety homolog 3 (Drosophila)
chr17_+_34969912 0.337 ENSMUST00000173680.1
 Gm20481
predicted gene 20481
chr6_+_117841174 0.331 ENSMUST00000112859.1
ENSMUST00000137224.1
ENSMUST00000164472.1
ENSMUST00000112861.1
ENSMUST00000035638.8
 Zfp637




zinc finger protein 637




chr10_+_84756055 0.330 ENSMUST00000060397.6
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr7_+_119690026 0.280 ENSMUST00000047045.8
 Acsm4
acyl-CoA synthetase medium-chain family member 4
chr7_-_57509995 0.275 ENSMUST00000068456.6
 Gabra5
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5
chr1_-_195131536 0.242 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr6_+_114648811 0.239 ENSMUST00000182510.1
 Atg7
autophagy related 7
chr15_-_74997634 0.214 ENSMUST00000023248.6
 Ly6a
lymphocyte antigen 6 complex, locus A
chr17_-_47692466 0.210 ENSMUST00000113300.1
 Prickle4
prickle homolog 4 (Drosophila)
chr11_-_68853119 0.189 ENSMUST00000018880.7
 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr11_-_68853019 0.154 ENSMUST00000108672.1
 Ndel1
nuclear distribution gene E-like homolog 1 (A. nidulans)
chr5_+_21737141 0.149 ENSMUST00000030882.5
 Pmpcb
peptidase (mitochondrial processing) beta
chr18_+_37496997 0.139 ENSMUST00000059571.5
 Pcdhb19
protocadherin beta 19
chr2_+_84798828 0.093 ENSMUST00000102642.2
ENSMUST00000150325.1
 Ube2l6

ubiquitin-conjugating enzyme E2L 6

chr2_+_34406845 0.092 ENSMUST00000124443.1
ENSMUST00000113124.1
 Mapkap1

mitogen-activated protein kinase associated protein 1

chr2_-_84650760 0.077 ENSMUST00000111691.1
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr7_+_80343091 0.075 ENSMUST00000032747.5
 Hddc3
HD domain containing 3
chr5_-_13121766 0.064 ENSMUST00000078246.4
 Gm10108
predicted pseudogene 10108
chr2_-_84650714 0.046 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
 Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr7_-_46919915 0.018 ENSMUST00000143413.1
ENSMUST00000014546.8
 Tsg101

tumor susceptibility gene 101


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.3 1.3 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.2 0.6 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.6 GO:0002339 B cell selection(GO:0002339)
0.1 0.2 GO:0039521 suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.1 2.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.6 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 0.3 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.1 0.8 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.1 0.6 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.7 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.2 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035)
0.0 0.1 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.8 GO:0006959 humoral immune response(GO:0006959)
0.0 0.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0044194 cytolytic granule(GO:0044194)
0.2 1.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.7 GO:0045298 tubulin complex(GO:0045298)
0.1 0.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.2 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.1 0.3 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.1 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.3 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)