Motif ID: Sox17

Z-value: 0.712


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496363_4496389-0.264.6e-02Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 17.174 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_52008210 8.556 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4
chr2_-_180889660 7.639 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr14_+_50944499 6.341 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr8_-_105471481 6.228 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr11_-_11970540 5.753 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr10_-_128176568 4.850 ENSMUST00000092033.2
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr19_+_55741810 4.620 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr6_-_148944750 4.293 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr12_+_24708241 3.957 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr4_+_41903610 3.663 ENSMUST00000098128.3
 Gm21541
predicted gene, 21541
chr10_+_11609256 3.429 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr15_+_85205949 3.017 ENSMUST00000057410.7
ENSMUST00000109432.3
 Fbln1

fibulin 1

chr1_+_135729147 2.760 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr2_-_127133909 2.627 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr13_+_54071815 2.592 ENSMUST00000021930.8
 Sfxn1
sideroflexin 1
chr4_-_42773993 2.532 ENSMUST00000095114.4
 Ccl21a
chemokine (C-C motif) ligand 21A (serine)
chr14_+_31134853 2.440 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr7_-_100656953 2.435 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
 Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr8_+_69822429 2.420 ENSMUST00000164890.1
ENSMUST00000034325.4
 Lpar2

lysophosphatidic acid receptor 2

chr9_+_66946057 2.390 ENSMUST00000040917.7
ENSMUST00000127896.1
 Rps27l

ribosomal protein S27-like

chr14_+_73142591 2.359 ENSMUST00000170368.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr5_-_130002838 2.358 ENSMUST00000111308.1
ENSMUST00000111307.1
 Gusb

glucuronidase, beta

chr11_-_77894096 2.352 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr6_+_83034173 2.320 ENSMUST00000000707.2
ENSMUST00000101257.3
 Loxl3

lysyl oxidase-like 3

chr3_-_58885212 2.103 ENSMUST00000055636.6
ENSMUST00000072551.6
ENSMUST00000051408.7
 Clrn1


clarin 1


chr2_+_102659213 1.797 ENSMUST00000111213.1
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_+_93453382 1.771 ENSMUST00000016033.7
 Lta4h
leukotriene A4 hydrolase
chr14_+_73142490 1.630 ENSMUST00000170370.1
ENSMUST00000164822.1
ENSMUST00000165429.1
 Rcbtb2


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2


chr11_-_97775876 1.609 ENSMUST00000107576.1
 1700001P01Rik
RIKEN cDNA 1700001P01 gene
chr15_+_74721193 1.570 ENSMUST00000070923.1
 Them6
thioesterase superfamily member 6
chr3_-_153725062 1.361 ENSMUST00000064460.5
 St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chrX_+_48695004 1.347 ENSMUST00000033433.2
 Rbmx2
RNA binding motif protein, X-linked 2
chr11_-_106388066 1.317 ENSMUST00000106813.2
ENSMUST00000141146.1
 Icam2

intercellular adhesion molecule 2

chr18_-_33213766 1.295 ENSMUST00000119991.1
ENSMUST00000118990.1
 Stard4

StAR-related lipid transfer (START) domain containing 4

chr8_+_107150621 1.264 ENSMUST00000034400.3
 Cyb5b
cytochrome b5 type B
chr8_-_94098811 1.258 ENSMUST00000034206.4
 Bbs2
Bardet-Biedl syndrome 2 (human)
chr5_-_123721007 1.244 ENSMUST00000031376.7
 Zcchc8
zinc finger, CCHC domain containing 8
chr18_-_33213832 1.202 ENSMUST00000025236.2
 Stard4
StAR-related lipid transfer (START) domain containing 4
chr15_-_96460838 1.198 ENSMUST00000047835.6
 Scaf11
SR-related CTD-associated factor 11
chr4_-_131937165 1.145 ENSMUST00000155990.1
 Epb4.1
erythrocyte protein band 4.1
chr15_+_27025386 1.115 ENSMUST00000169678.2
 Gm6576
predicted gene 6576
chr2_-_142901506 1.071 ENSMUST00000043589.7
 Kif16b
kinesin family member 16B
chr7_-_104353328 1.071 ENSMUST00000130139.1
ENSMUST00000059037.8
 Trim12c

tripartite motif-containing 12C

chr2_-_121456693 1.069 ENSMUST00000110613.2
ENSMUST00000056312.3
 Serinc4

serine incorporator 4

chr7_-_102210120 1.060 ENSMUST00000070165.5
 Nup98
nucleoporin 98
chr12_-_84400851 0.976 ENSMUST00000117286.1
 Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chr2_+_155751117 0.965 ENSMUST00000029140.5
ENSMUST00000132608.1
 Procr

protein C receptor, endothelial

chr5_-_107597577 0.952 ENSMUST00000100949.3
ENSMUST00000078021.6
 Glmn

glomulin, FKBP associated protein

chr8_-_111854278 0.947 ENSMUST00000034432.5
 Cfdp1
craniofacial development protein 1
chr12_-_84400929 0.945 ENSMUST00000122194.1
 Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chr6_+_121245903 0.929 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr17_-_55712571 0.830 ENSMUST00000086876.5
 Pot1b
protection of telomeres 1B
chr2_+_121456963 0.790 ENSMUST00000126764.1
 Hypk
huntingtin interacting protein K
chr11_+_78346666 0.668 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr10_+_94575257 0.661 ENSMUST00000121471.1
 Tmcc3
transmembrane and coiled coil domains 3
chr11_-_86807624 0.626 ENSMUST00000018569.7
 Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr10_+_14523062 0.618 ENSMUST00000096020.5
 Gm10335
predicted gene 10335
chr9_+_50494516 0.578 ENSMUST00000114474.1
 1600029D21Rik
RIKEN cDNA 1600029D21 gene
chr7_-_79466167 0.558 ENSMUST00000073889.7
 Polg
polymerase (DNA directed), gamma
chr18_-_36197343 0.542 ENSMUST00000115713.1
ENSMUST00000115712.1
 Nrg2

neuregulin 2

chr11_+_78343475 0.470 ENSMUST00000002127.7
ENSMUST00000108295.1
 Unc119

unc-119 homolog (C. elegans)

chr2_-_26409100 0.452 ENSMUST00000114090.1
 Inpp5e
inositol polyphosphate-5-phosphatase E
chr5_-_107597533 0.442 ENSMUST00000124140.1
 Glmn
glomulin, FKBP associated protein
chr5_-_125434048 0.433 ENSMUST00000169485.1
 Dhx37
DEAH (Asp-Glu-Ala-His) box polypeptide 37
chr5_-_38502107 0.427 ENSMUST00000005238.6
 Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr4_-_119173849 0.414 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
 Zfp691


zinc finger protein 691


chr18_+_60560730 0.414 ENSMUST00000025506.6
 Rbm22
RNA binding motif protein 22
chr3_-_158016419 0.362 ENSMUST00000127778.1
 Srsf11
serine/arginine-rich splicing factor 11
chr2_+_55411790 0.329 ENSMUST00000155997.1
ENSMUST00000128307.1
 Gm14033

predicted gene 14033

chr18_+_35599219 0.322 ENSMUST00000115734.1
 Paip2
polyadenylate-binding protein-interacting protein 2
chr12_+_84970897 0.300 ENSMUST00000021669.8
ENSMUST00000171040.1
 Fcf1

FCF1 small subunit (SSU) processome component homolog (S. cerevisiae)

chr7_-_127890918 0.279 ENSMUST00000121394.1
 Prss53
protease, serine, 53
chr2_+_18677002 0.162 ENSMUST00000028071.6
 Bmi1
Bmi1 polycomb ring finger oncogene
chr19_+_6306456 0.130 ENSMUST00000025681.7
 Cdc42bpg
CDC42 binding protein kinase gamma (DMPK-like)
chr7_-_98112618 0.114 ENSMUST00000153657.1
 Myo7a
myosin VIIA
chr16_+_8470763 0.107 ENSMUST00000046470.9
ENSMUST00000150790.1
ENSMUST00000142899.1
 Mettl22


methyltransferase like 22


chr7_-_143549055 0.083 ENSMUST00000072727.5
 Nap1l4
nucleosome assembly protein 1-like 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 17.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.1 6.3 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
1.0 3.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.8 2.4 GO:0006553 lysine metabolic process(GO:0006553)
0.6 5.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.6 4.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.4 4.0 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.3 1.3 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.3 1.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.3 0.8 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.3 1.8 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.2 2.2 GO:0050957 equilibrioception(GO:0050957)
0.2 1.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.2 2.5 GO:0034433 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.2 2.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.2 2.5 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 1.4 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.1 1.1 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) telomere localization(GO:0034397)
0.1 2.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 2.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.9 GO:0030813 positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.1 0.9 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 6.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 0.3 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 1.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 2.6 GO:0006826 iron ion transport(GO:0006826)
0.1 1.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.2 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1 1.0 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.4 GO:0046415 urate metabolic process(GO:0046415)
0.0 2.8 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.6 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 8.6 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.5 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0 0.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 1.3 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 1.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 2.2 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 4.3 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.3 GO:0045947 negative regulation of translational initiation(GO:0045947)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0071953 fibrinogen complex(GO:0005577) elastic fiber(GO:0071953)
0.8 4.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 4.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.4 2.6 GO:0000796 condensin complex(GO:0000796)
0.4 1.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.2 1.1 GO:1990462 omegasome(GO:1990462)
0.2 4.3 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.4 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 1.3 GO:0034464 BBSome(GO:0034464)
0.1 0.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 0.8 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 1.3 GO:0005686 U2 snRNP(GO:0005686)
0.1 2.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 1.8 GO:0030673 axolemma(GO:0030673)
0.0 4.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.6 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 1.1 GO:0051233 spindle midzone(GO:0051233)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 2.3 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.8 4.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.8 2.4 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.8 2.3 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.6 3.0 GO:0070051 fibrinogen binding(GO:0070051)
0.6 2.4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.5 1.4 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.4 1.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 2.4 GO:0008494 translation activator activity(GO:0008494)
0.4 1.9 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.3 1.8 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.3 5.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 1.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 4.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 0.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.2 2.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 1.1 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.9 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.1 0.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 2.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 17.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.5 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.1 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.5 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.3 GO:0090079 translation repressor activity, nucleic acid binding(GO:0000900) translation regulator activity, nucleic acid binding(GO:0090079)
0.0 1.3 GO:0020037 heme binding(GO:0020037)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 8.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.1 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 2.9 GO:0008022 protein C-terminus binding(GO:0008022)