Motif ID: Sox18_Sox12

Z-value: 0.724

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox18mm10_v2_chr2_-_181671622_181671645-0.392.1e-03Click!
Sox12mm10_v2_chr2_-_152398046_1523980760.047.7e-01Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_11970540 2.366 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr9_-_60511003 2.330 ENSMUST00000098660.3
 Thsd4
thrombospondin, type I, domain containing 4
chr14_+_62837679 2.265 ENSMUST00000014691.8
 Wdfy2
WD repeat and FYVE domain containing 2
chr18_-_74961252 2.060 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr6_-_113934679 1.818 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr8_-_67910911 1.748 ENSMUST00000093468.5
 Psd3
pleckstrin and Sec7 domain containing 3
chr18_-_88927447 1.745 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr11_-_62392605 1.672 ENSMUST00000151498.2
ENSMUST00000159069.1
 Ncor1

nuclear receptor co-repressor 1

chr14_+_116925379 1.645 ENSMUST00000088483.3
 Gpc6
glypican 6
chr7_+_24271568 1.530 ENSMUST00000032696.6
 Zfp93
zinc finger protein 93
chr16_-_91618986 1.472 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr3_+_63295815 1.455 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr16_-_23520579 1.421 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr7_+_75643223 1.404 ENSMUST00000137959.1
 Akap13
A kinase (PRKA) anchor protein 13
chrX_+_9885622 1.379 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr14_-_100149764 1.352 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr5_+_14514918 1.345 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr16_-_50330987 1.285 ENSMUST00000114488.1
 Bbx
bobby sox homolog (Drosophila)
chr4_-_58499398 1.283 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr5_+_92809372 1.234 ENSMUST00000113054.2
 Shroom3
shroom family member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 2.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 2.3 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.4 2.2 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.7 2.1 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 2.0 GO:0042118 endothelial cell activation(GO:0042118)
0.0 1.9 GO:0051028 mRNA transport(GO:0051028)
0.3 1.8 GO:0048840 otolith development(GO:0048840)
0.4 1.7 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.2 1.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 1.5 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 1.5 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 1.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.4 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.3 1.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 1.3 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.2 1.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.2 1.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 GO:0005769 early endosome(GO:0005769)
0.8 2.5 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 2.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 2.3 GO:0001527 microfibril(GO:0001527)
0.1 2.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 1.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.7 GO:0001772 immunological synapse(GO:0001772)
0.1 1.5 GO:0017119 Golgi transport complex(GO:0017119)
0.3 1.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.3 1.3 GO:0044316 cone cell pedicle(GO:0044316)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.2 GO:0005903 brush border(GO:0005903)
0.1 1.1 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 1.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 2.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.4 2.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 2.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.5 2.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.5 2.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 1.7 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 1.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.6 GO:0051015 actin filament binding(GO:0051015)
0.0 1.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.3 GO:0030507 spectrin binding(GO:0030507)
0.3 1.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 1.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)